Ethanol induces microglial cell death via the NOX/ROS/PARP/TRPM2 signalling pathway
Microglial cells are the primary immune cell resident in the brain. Growing evidence indicates that microglial cells play a prominent role in alcohol-induced brain pathologies. However, alcohol-induced effects on microglial cells and the underlying mechanisms are not fully understood, and evidence e...
| Main Authors: | Sha’fie, Muhammad Syahreel Azhad, Rathakrishnan, Sharani, Hazanol, Iffa Nadhira, Mohd Dali, Mohd Haziq Izzazuddin, Khayat, Mohd Ezuan, Ahmad, Syahida, Hussin, Yazmin, Alitheen, Noorjahan Banu, Jiang, Lin Hua, Syed Mortadza, Sharifah Alawieyah |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/88851/ http://psasir.upm.edu.my/id/eprint/88851/1/ABSTRACT.pdf |
Similar Items
Signalling mechanism in TRPM2-dependent copper- induced HT22 cell death
by: Rathakrishnan, Sharani, et al.
Published: (2023)
by: Rathakrishnan, Sharani, et al.
Published: (2023)
TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies
by: Malko, Philippa, et al.
Published: (2019)
by: Malko, Philippa, et al.
Published: (2019)
The TRPM2 channel nexus from oxidative damage to Alzheimers pathologies: an emerging novel intervention target for age-related dementia
by: Jiang, Lin-Hua, et al.
Published: (2018)
by: Jiang, Lin-Hua, et al.
Published: (2018)
Predisposition to Alzheimer’s and age-related brain pathologies by PM2.5 exposure: Perspective on the roles of oxidative stress and TRPM2 channel
by: Syed Mortadza, Sharifah A., et al.
Published: (2020)
by: Syed Mortadza, Sharifah A., et al.
Published: (2020)
Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013)
by: Hassan, Samia
Published: (2013)
Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy
by: Yusoh, Nur Aininie, et al.
Published: (2020)
by: Yusoh, Nur Aininie, et al.
Published: (2020)
Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator
by: Chong, S., et al.
Published: (2014)
by: Chong, S., et al.
Published: (2014)
The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation
by: Walsh, T., et al.
Published: (2014)
by: Walsh, T., et al.
Published: (2014)
Dengue Virus-Induced Reactive Oxygen Species Production in Rat Microglial Cells
by: Lattapon, Suwanprinya, et al.
Published: (2017)
by: Lattapon, Suwanprinya, et al.
Published: (2017)
Effects of Age on Microglial Responses to Cellular Stress Induced by Lipopolysacharides and Beta Amyliod
by: Subramaiam, Hemavathy
Published: (2011)
by: Subramaiam, Hemavathy
Published: (2011)
Evidence for a Retroviral Insertion in TRPM1 as the Cause of Congenital Stationary Night Blindness and Leopard Complex Spotting in the Horse
by: Bellone, Rebecca, et al.
Published: (2013)
by: Bellone, Rebecca, et al.
Published: (2013)
The Importance Of Rate And Time Dependence On Conversion Of NOx In The Cleaning Of NOx In Exhaust Gases Using Ozone.
by: Patah, Abir Abdul, et al.
Published: (2005)
by: Patah, Abir Abdul, et al.
Published: (2005)
Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival
by: Mukhophadyay, Asima, et al.
Published: (2012)
by: Mukhophadyay, Asima, et al.
Published: (2012)
Potential association of nicotinamide on the telomerase activity and telomere length mediated by PARP-1 mechanism in myeloid cancer
by: Nur Rasyidah Muhammad,, et al.
Published: (2020)
by: Nur Rasyidah Muhammad,, et al.
Published: (2020)
PARP inhibitor combinations with Olaparib for synergistic efficacy in Olaparib-resistant triple-negative breast cancer cells
by: Yusoh, Nur Aininie
Published: (2023)
by: Yusoh, Nur Aininie
Published: (2023)
Isolation, production and characterization of keratinase from Bacillus sp. khayat
by: Khayat, Mohd Ezuan
Published: (2011)
by: Khayat, Mohd Ezuan
Published: (2011)
Ficus deltoidea: potential inhibitor of pro-inflammatory mediators in lipopolysaccharide-induced activation of microglial cells
by: Zolkiffly, Siti Zaidathul Iman, et al.
Published: (2021)
by: Zolkiffly, Siti Zaidathul Iman, et al.
Published: (2021)
Plasma small extracellular vesicles as biomarkers in neurodegenerative dementias: focusing on microglial enrichment in dementia with Lewy bodies
by: Isik, Fatma Busra
Published: (2025)
by: Isik, Fatma Busra
Published: (2025)
Antioxidant and anti-inflammatory properties of Punica granatum peel methanolic extract in BV2 microglial cell line
by: Imam Syafii, Raudhatul Falah, et al.
Published: (2021)
by: Imam Syafii, Raudhatul Falah, et al.
Published: (2021)
Effects of nicotinamide and nilotinib on telomerase activity and telomere length associated with parp-1 regulation in k562 myeloid cell line
by: Muhammad, Nur Rasyidah
Published: (2023)
by: Muhammad, Nur Rasyidah
Published: (2023)
Cloud Based Ros Implementation for Indoor Robot
by: Lim, Jia Zhi
Published: (2019)
by: Lim, Jia Zhi
Published: (2019)
The effects of pressure and NOx in the partial oxidation of methane to methanol
by: Chan, Y.L., et al.
Published: (2010)
by: Chan, Y.L., et al.
Published: (2010)
Nox emission modelling from industrial steam boilers
by: Abdullah, Ahmad Makmom, et al.
Published: (2015)
by: Abdullah, Ahmad Makmom, et al.
Published: (2015)
hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells
by: Indran, I., et al.
Published: (2011)
by: Indran, I., et al.
Published: (2011)
Potential inhibition of pro-inflammatory mediators by Ficus deltoidea jack leaves aqueous extract in lipopolysaccharide-induced microglial cells
by: Zolkiffly, Siti Zaidathul Iman
Published: (2021)
by: Zolkiffly, Siti Zaidathul Iman
Published: (2021)
Effects of varying EGR rates on the nitric oxide (NOx) emissions
by: Wasiu, Saheed, et al.
Published: (2010)
by: Wasiu, Saheed, et al.
Published: (2010)
Computational fluid dynamic modelling of NOx formation in
diesel engine
by: S. S., Hoseini, et al.
Published: (2020)
by: S. S., Hoseini, et al.
Published: (2020)
Performance and NOx emissions of a diesel engine with water injection
by: Aziz, Amir, et al.
Published: (2017)
by: Aziz, Amir, et al.
Published: (2017)
Effects of Biodiesel Saturation Degrees on NOx Emission and FTIR Spectroscopy
by: Mohd Fareez Edzuan, Bin Abdullah, et al.
Published: (2016)
by: Mohd Fareez Edzuan, Bin Abdullah, et al.
Published: (2016)
ROS, autophagy, mitochondria and cancer: Ras, the hidden master?
by: Bellot, G., et al.
Published: (2013)
by: Bellot, G., et al.
Published: (2013)
ROS in platelet biology: Functional aspects and methodological insights
by: Masselli, E., et al.
Published: (2020)
by: Masselli, E., et al.
Published: (2020)
Molecular mechanisms of ROS production and oxidative stress in diabetes
by: Newsholme, Philip, et al.
Published: (2016)
by: Newsholme, Philip, et al.
Published: (2016)
Investigation Of Ros Based Vehicle State Estimation With Uncertainties
by: Siti Nuraini, Che Huhaimi
Published: (2022)
by: Siti Nuraini, Che Huhaimi
Published: (2022)
Metallointercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition
by: Yusoh, Nur Aininie, et al.
Published: (2020)
by: Yusoh, Nur Aininie, et al.
Published: (2020)
Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells
by: Yusoh, Nur Aininie, et al.
Published: (2023)
by: Yusoh, Nur Aininie, et al.
Published: (2023)
Effect of combination therapy of ruthenium polypyridyl complex, [Ru(dppz)2(PIP)]2+ and parp inhibitors against several cancer cell lines
by: Yusoh, Nur Aininie
Published: (2020)
by: Yusoh, Nur Aininie
Published: (2020)
Characterisation of responses to PGE2-G in the porcine coronary artery, rat aorta and murine microglial cell line BV-2
by: Vadgama, Anisha
Published: (2019)
by: Vadgama, Anisha
Published: (2019)
Calcitonin gene-related peptide-expressing sensory neurons and spinal microglial reactivity contribute to pain states in collagen-induced arthritis
by: Nieto, Francisco R., et al.
Published: (2015)
by: Nieto, Francisco R., et al.
Published: (2015)
Reduction of NOx emissions from gas turbine combustor with fuel staging
by: Mohammad Nazri Mohd.la'afar,
Published: (2002)
by: Mohammad Nazri Mohd.la'afar,
Published: (2002)
Mitigation of NOx emission by monophenolic antioxidants blended in POME biodiesel blends
by: Mohd Hafiz, Ali, et al.
Published: (2020)
by: Mohd Hafiz, Ali, et al.
Published: (2020)
Similar Items
-
Signalling mechanism in TRPM2-dependent copper- induced HT22 cell death
by: Rathakrishnan, Sharani, et al.
Published: (2023) -
TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies
by: Malko, Philippa, et al.
Published: (2019) -
The TRPM2 channel nexus from oxidative damage to Alzheimers pathologies: an emerging novel intervention target for age-related dementia
by: Jiang, Lin-Hua, et al.
Published: (2018) -
Predisposition to Alzheimer’s and age-related brain pathologies by PM2.5 exposure: Perspective on the roles of oxidative stress and TRPM2 channel
by: Syed Mortadza, Sharifah A., et al.
Published: (2020) -
Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013)