Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system
The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac ( DCF− ), as an anti-inflammatory...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88769/ http://psasir.upm.edu.my/id/eprint/88769/1/ION.pdf |
| _version_ | 1848860691976421376 |
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| author | Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_facet | Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_sort | Mohamed Almbrok, Eissa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac ( DCF− ), as an anti-inflammatory, anti-rheumatic, antipyretic, and analgesic treatment in common use in biomedical applications, were also investigated across microporous silicon nitride-modified liquid interface. Thus, some thermodynamic variables for DCF− , such as the standard Gibbs energy of transfer, the standard transfer potential and lipophilicity were estimated. Furthermore, the influence of possible interfering substances (ascorbic acid, sugar, amino acid, urea, and metal ions) on the detection of DCF− was investigated. An electrochemical DCF sensor is investigated using differential pulse voltammetry (DPV) as the quantification technique, a linear range of 8–56 µM and a limit of detection of 1.5 µM was possible due to the miniaturized interfaces formed within silicon nitride. |
| first_indexed | 2025-11-15T12:49:16Z |
| format | Article |
| id | upm-88769 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:49:16Z |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-887692021-10-06T15:29:16Z http://psasir.upm.edu.my/id/eprint/88769/ Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza The electrochemical behavior when the liquid–liquid interface was modified by commercially available, microporous silicon nitride membrane, was achieved using cyclic voltammetry with tetramethyl ammonium. The transfer characteristics of the ionizable drug diclofenac ( DCF− ), as an anti-inflammatory, anti-rheumatic, antipyretic, and analgesic treatment in common use in biomedical applications, were also investigated across microporous silicon nitride-modified liquid interface. Thus, some thermodynamic variables for DCF− , such as the standard Gibbs energy of transfer, the standard transfer potential and lipophilicity were estimated. Furthermore, the influence of possible interfering substances (ascorbic acid, sugar, amino acid, urea, and metal ions) on the detection of DCF− was investigated. An electrochemical DCF sensor is investigated using differential pulse voltammetry (DPV) as the quantification technique, a linear range of 8–56 µM and a limit of detection of 1.5 µM was possible due to the miniaturized interfaces formed within silicon nitride. Multidisciplinary Digital Publishing Institute 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88769/1/ION.pdf Mohamed Almbrok, Eissa and Yusof, Nor Azah and Abdullah, Jaafar and Mohd Zawawi, Ruzniza (2020) Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system. Chemosensors, 8 (1). pp. 1-16. ISSN 2227-9040 https://www.mdpi.com/2227-9040/8/1/11 10.3390/chemosensors8010011 |
| spellingShingle | Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system |
| title | Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system |
| title_full | Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system |
| title_fullStr | Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system |
| title_full_unstemmed | Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system |
| title_short | Electrochemical behavior and detection of diclofenac at a microporous Si3N4 membrane modified water-1,6-dichlorohexane interface system |
| title_sort | electrochemical behavior and detection of diclofenac at a microporous si3n4 membrane modified water-1,6-dichlorohexane interface system |
| url | http://psasir.upm.edu.my/id/eprint/88769/ http://psasir.upm.edu.my/id/eprint/88769/ http://psasir.upm.edu.my/id/eprint/88769/ http://psasir.upm.edu.my/id/eprint/88769/1/ION.pdf |