Elecated levels of IL-8 in fatal leptospirosis
Leptospirosis causes a wide range of clinical outcomes, including organ failure and death. Early treatment significantly increases the chances of cure. Interleukin-8 (IL-8) is a chemoattractant cytokine for neutrophil and is associated with multiple organ failure. Research has indicated IL-8 to be r...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88764/ http://psasir.upm.edu.my/id/eprint/88764/1/CYTO.pdf |
| _version_ | 1848860690625855488 |
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| author | Wan Yusoff, Wan Shahriman Yushdie Abdullah, Maha Sekawi, Zamberi Amran, Fairuz Yuhana, Muhammad Yazli Mohd Taib, Niazlin Md Shah, Anim Nordin, Syafinaz Amin |
| author_facet | Wan Yusoff, Wan Shahriman Yushdie Abdullah, Maha Sekawi, Zamberi Amran, Fairuz Yuhana, Muhammad Yazli Mohd Taib, Niazlin Md Shah, Anim Nordin, Syafinaz Amin |
| author_sort | Wan Yusoff, Wan Shahriman Yushdie |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Leptospirosis causes a wide range of clinical outcomes, including organ failure and death. Early treatment significantly increases the chances of cure. Interleukin-8 (IL-8) is a chemoattractant cytokine for neutrophil and is associated with multiple organ failure. Research has indicated IL-8 to be raised in severe and fatal cases of leptospirosis, but its suitability as a prognostic biomarker has yet to be confirmed. This study aimed to evaluate the significance of IL-8 with the clinical outcomes of leptospirosis patients. Plasma IL-8 was measured in fifty-two samples from hospitalized patients and nineteen healthy controls. The comparisons were made between mild, severe-survived and fatal groups identified by clinical or laboratory findings. IL-8 was significantly higher in fatal (p = 0.01) compared to mild cases. IL-8 was also significantly higher in fatal (p = 0.02) when compared to survived cases of leptospirosis. IL-8 levels in the plasma of fatal leptospirosis cases were significantly elevated compared to survived cases and may serve as a potential prognostic biomarker in determining the possible outcome of leptospirosis patients. |
| first_indexed | 2025-11-15T12:49:15Z |
| format | Article |
| id | upm-88764 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:49:15Z |
| publishDate | 2020 |
| publisher | Taylor and Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-887642021-10-06T15:02:43Z http://psasir.upm.edu.my/id/eprint/88764/ Elecated levels of IL-8 in fatal leptospirosis Wan Yusoff, Wan Shahriman Yushdie Abdullah, Maha Sekawi, Zamberi Amran, Fairuz Yuhana, Muhammad Yazli Mohd Taib, Niazlin Md Shah, Anim Nordin, Syafinaz Amin Leptospirosis causes a wide range of clinical outcomes, including organ failure and death. Early treatment significantly increases the chances of cure. Interleukin-8 (IL-8) is a chemoattractant cytokine for neutrophil and is associated with multiple organ failure. Research has indicated IL-8 to be raised in severe and fatal cases of leptospirosis, but its suitability as a prognostic biomarker has yet to be confirmed. This study aimed to evaluate the significance of IL-8 with the clinical outcomes of leptospirosis patients. Plasma IL-8 was measured in fifty-two samples from hospitalized patients and nineteen healthy controls. The comparisons were made between mild, severe-survived and fatal groups identified by clinical or laboratory findings. IL-8 was significantly higher in fatal (p = 0.01) compared to mild cases. IL-8 was also significantly higher in fatal (p = 0.02) when compared to survived cases of leptospirosis. IL-8 levels in the plasma of fatal leptospirosis cases were significantly elevated compared to survived cases and may serve as a potential prognostic biomarker in determining the possible outcome of leptospirosis patients. Taylor and Francis 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88764/1/CYTO.pdf Wan Yusoff, Wan Shahriman Yushdie and Abdullah, Maha and Sekawi, Zamberi and Amran, Fairuz and Yuhana, Muhammad Yazli and Mohd Taib, Niazlin and Md Shah, Anim and Nordin, Syafinaz Amin (2020) Elecated levels of IL-8 in fatal leptospirosis. Pathogens and Global Health, 114 (2). 99 - 103. ISSN 2047-7724; ESSN: 2047-7732 https://www.tandfonline.com/doi/abs/10.1080/20477724.2020.1724356?journalCode=ypgh20 10.1080/20477724.2020.1724356 |
| spellingShingle | Wan Yusoff, Wan Shahriman Yushdie Abdullah, Maha Sekawi, Zamberi Amran, Fairuz Yuhana, Muhammad Yazli Mohd Taib, Niazlin Md Shah, Anim Nordin, Syafinaz Amin Elecated levels of IL-8 in fatal leptospirosis |
| title | Elecated levels of IL-8 in fatal leptospirosis |
| title_full | Elecated levels of IL-8 in fatal leptospirosis |
| title_fullStr | Elecated levels of IL-8 in fatal leptospirosis |
| title_full_unstemmed | Elecated levels of IL-8 in fatal leptospirosis |
| title_short | Elecated levels of IL-8 in fatal leptospirosis |
| title_sort | elecated levels of il-8 in fatal leptospirosis |
| url | http://psasir.upm.edu.my/id/eprint/88764/ http://psasir.upm.edu.my/id/eprint/88764/ http://psasir.upm.edu.my/id/eprint/88764/ http://psasir.upm.edu.my/id/eprint/88764/1/CYTO.pdf |