Development of cell penetrating peptides for effective delivery of recombinant factors into target cells
The cell membrane is a protective layer that strictly controls the passage of molecules restricting the delivery of biomolecules such as drugs, oligonucleotides, peptides, and siRNA into the cells. This shortcoming has been overcome by the discovery of Cell-Penetrating Peptides (CPPs) that has under...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bentham Science
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88430/ http://psasir.upm.edu.my/id/eprint/88430/1/ABSTRACT.pdf |
| _version_ | 1848860618105290752 |
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| author | Vijakumaran, Ubashini Nordin, Fazlina Abdul Hamid, Zariyantey Abdullah, Maha Tye, Gee Jun |
| author_facet | Vijakumaran, Ubashini Nordin, Fazlina Abdul Hamid, Zariyantey Abdullah, Maha Tye, Gee Jun |
| author_sort | Vijakumaran, Ubashini |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The cell membrane is a protective layer that strictly controls the passage of molecules restricting the delivery of biomolecules such as drugs, oligonucleotides, peptides, and siRNA into the cells. This shortcoming has been overcome by the discovery of Cell-Penetrating Peptides (CPPs) that has undergone 30 years of evolution. To date, CPPs are largely modified to improve its efficacy and to suit the different delivery applications. The modes of CPPs penetration are still an unresolved mystery and requires further investigations to increase its effectiveness and to diversify its use. Despite having huge potential as a biomolecule carrier, CPPs also have some drawbacks. In this review, the natural and synthetic CPPs, the modifications that have been conducted on CPPs to improve its efficacy, its extended applications, modes of penetration and limitation as well as challenges will be discussed. |
| first_indexed | 2025-11-15T12:48:06Z |
| format | Article |
| id | upm-88430 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:48:06Z |
| publishDate | 2020 |
| publisher | Bentham Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-884302021-12-28T06:46:20Z http://psasir.upm.edu.my/id/eprint/88430/ Development of cell penetrating peptides for effective delivery of recombinant factors into target cells Vijakumaran, Ubashini Nordin, Fazlina Abdul Hamid, Zariyantey Abdullah, Maha Tye, Gee Jun The cell membrane is a protective layer that strictly controls the passage of molecules restricting the delivery of biomolecules such as drugs, oligonucleotides, peptides, and siRNA into the cells. This shortcoming has been overcome by the discovery of Cell-Penetrating Peptides (CPPs) that has undergone 30 years of evolution. To date, CPPs are largely modified to improve its efficacy and to suit the different delivery applications. The modes of CPPs penetration are still an unresolved mystery and requires further investigations to increase its effectiveness and to diversify its use. Despite having huge potential as a biomolecule carrier, CPPs also have some drawbacks. In this review, the natural and synthetic CPPs, the modifications that have been conducted on CPPs to improve its efficacy, its extended applications, modes of penetration and limitation as well as challenges will be discussed. Bentham Science 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88430/1/ABSTRACT.pdf Vijakumaran, Ubashini and Nordin, Fazlina and Abdul Hamid, Zariyantey and Abdullah, Maha and Tye, Gee Jun (2020) Development of cell penetrating peptides for effective delivery of recombinant factors into target cells. Protein and Peptide Letters, 27 (1). pp. 1-10. ISSN 0929-8665; ESSN: 1875-5305 https://www.eurekaselect.net/article/106913 10.2174/0929866527666200525164135 |
| spellingShingle | Vijakumaran, Ubashini Nordin, Fazlina Abdul Hamid, Zariyantey Abdullah, Maha Tye, Gee Jun Development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| title | Development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| title_full | Development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| title_fullStr | Development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| title_full_unstemmed | Development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| title_short | Development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| title_sort | development of cell penetrating peptides for effective delivery of recombinant factors into target cells |
| url | http://psasir.upm.edu.my/id/eprint/88430/ http://psasir.upm.edu.my/id/eprint/88430/ http://psasir.upm.edu.my/id/eprint/88430/ http://psasir.upm.edu.my/id/eprint/88430/1/ABSTRACT.pdf |