Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

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Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Aristolochic acid I (AAI) is a well-known genotoxic kidney carcinogen. Metabolic conversion of AAI into the DNA-reactive aristolactam-nitrenium ion is involved in the mode of action of tumor formation. This study aims to predict in vivo AAI-DNA adduct formation in the kidney of rat, mouse and human...

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Bibliographic Details
Main Authors:	Abdullah, Rozaini, Wesseling, Sebastiaan, Spenkelink, Bert, Louisse, Jochem, Punt, Ans, Rietjens, Ivonne M. C. M.
Format:	Article
Language:	English
Published:	John Wiley & Sons 2020
Online Access:	http://psasir.upm.edu.my/id/eprint/88350/ http://psasir.upm.edu.my/id/eprint/88350/1/ABSTRACT.pdf

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