Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

QR Code

Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Aristolochic acid I (AAI) is a well-known genotoxic kidney carcinogen. Metabolic conversion of AAI into the DNA-reactive aristolactam-nitrenium ion is involved in the mode of action of tumor formation. This study aims to predict in vivo AAI-DNA adduct formation in the kidney of rat, mouse and human...

Full description

Bibliographic Details
Main Authors:	Abdullah, Rozaini, Wesseling, Sebastiaan, Spenkelink, Bert, Louisse, Jochem, Punt, Ans, Rietjens, Ivonne M. C. M.
Format:	Article
Language:	English
Published:	John Wiley & Sons 2020
Online Access:	http://psasir.upm.edu.my/id/eprint/88350/ http://psasir.upm.edu.my/id/eprint/88350/1/ABSTRACT.pdf

Similar Items

Risk assessment of plant food supplements and other herbal products containing aristolochic acids using margin of exposure (MOE) approach
by: Abdullah, Rozaini, et al.
Published: (2016)

Integrated strategy for the assessment of kidney toxicity: the case of aristolochic acids
by: Abdullah, Rozaini
Published: (2017)

Detection of serum AFB1-lysine adduct in Malaysia and its association with liver and kidney functions
by: Sabran, Mohd Redzwan, et al.
Published: (2014)

Mouse mitochondrial lipid composition is defined by age in brain and muscle
by: Pollard, Amelia K., et al.
Published: (2017)

Clinical submission of supernumerary head of adducter brevis muscle
by: Vandana M,, et al.
Published: (2011)

LIM kinase and metanephric mesenchymal cell migration in the developing mouse kidney
by: Sparrow, Alexander
Published: (2016)

The precerebellar linear nucleus in the mouse defined by connections, immunohistochemistry, and gene expression
by: Fu, Y., et al.
Published: (2009)

Serendipitous compositional and structural diversity in urotropine adducts of binary cadmium xanthates
by: Tan, Yee Seng *, et al.
Published: (2016)

Novel methods for synthesizing halide-free alane without the formation of adducts
by: Dinh, L., et al.
Published: (2012)

Knee strength and knee adduction moments following arthroscopic partial meniscectomy
by: Sturnieks, D, et al.
Published: (2008)

Chitosan-benzofuran adduct for potential biomedical applications: Improved antibacterial and antifungal properties
by: Elnashar, Magdy, et al.
Published: (2015)

Ferroelastic Phase Transition In Some Phenols-Amines Adducts – Experimental And Theoretical Findings.
by: Fun, H.K., et al.
Published: (2004)

Hip adduction and abduction strength profiles in elite, sub-elite and amateur Australian footballers
by: Prendergast, N., et al.
Published: (2015)

Structure and decomposition of zinc borohydride ammonia adduct: towards a pure hydrogen release
by: Gu, Q., et al.
Published: (2012)

DNA damage and adduct formation in immune organs of developing chicks by polycyclic aromatic hydrocarbons
by: A. R., Nisha, et al.
Published: (2017)

Defining antibiotic dosing in lung infections
by: Jamal, Jannatul-Ain, et al.
Published: (2013)

A novel seven-coordinate adduct of cadmium(II) in an N3S3 macrocycle environment
by: Ismail, A.R., et al.
Published: (2003)

The interfascicular trigeminal nucleus: A precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping
by: Fu, Y., et al.
Published: (2012)

Precerebellar cell groups in the hindbrain of the mouse defined by retrograde tracing and correlated with Wnt1-cre genetic labeling
by: Fu, Y., et al.
Published: (2011)

Synthesis and structural characterization of some adducts of 1,4-dithian and -oxathian with silver(I) nitrate and perchlorate
by: Effendy, et al.
Published: (2003)

Studies toward the total synthesis of mulberry dielsalder adducts morusalbanol A and sorocein B / Tee Jia Ti
by: Tee, Jia Ti
Published: (2016)

Synthesis, Crystal Structures And Photoluminescence Studies Of Metal Complexes Containing Ligands Derived From Diels-Alder Adduct
by: Azmi, Nurul Izzati
Published: (2021)

Reactive oxygen species level defines two functionally distinctive stages of inflammatory dendritic cell development from mouse bone marrow
by: Sheng, K., et al.
Published: (2010)

Mono urotropine adducts of some binary zinc xanthates and dithiocarbamates: solid-state molecular structures and supramolecular self-assembly
by: Câmpian, Marius V., et al.
Published: (2016)

Study Of Hydrogen Bondings In Phenol-Amine Adducts [QP517.H93 M991 2008 f rb].
by: Rosli, Mohd Mustaqim
Published: (2008)

The effects of chronic low dose exposure of chlorpyrifos on the rat kidney
by: Aung, Sanda, et al.
Published: (2020)

Anion-Directed Solid-State Structures of Copper(I) and Silver(I) Adducts of Ruthenium Ethyne-1,2-diyl Compounds
by: Fuller, Rebecca, et al.
Published: (2015)

Lewis base complexes of AlH3: Structural determination of monomeric and polymeric adducts by X-ray crystallography and DFT calculations
by: Humphries, Terry, et al.
Published: (2013)

[1,5] and [1,2] acetyl shifts in Diels-Alder adducts of 2-acetyl-6-methyl-l,4-benzoquinone
by: Ahmad, Faujan, et al.
Published: (1981)

Impact of elemental iron on human spermatozoa and mouse embryonic development in vitro in a defined synthetic protein-free culture system / Safaa Mahmoud Naes
by: Safaa, Mahmoud Naes
Published: (2018)

Virtual Mouse
by: Wan, Chung Son
Published: (2016)

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney
by: Stevens, Megan, et al.
Published: (2017)

LOW DOSE DIETARY NITRATE IMPROVES ENDOTHELIAL DYSFUNCTION IN THE APOE(-/-) MOUSE
by: Bakker, J., et al.
Published: (2016)

Kidney disease explained
by: The Star
Published: (2021)

Calculation of mean kidney dose for a Co-57 external radiation source
by: Supian Samat,
Published: (1996)

Transient Acute Kidney Injury (AKI) is common following significant kidney hypoperfusion
by: Md Ralib, Azrina, et al.
Published: (2012)

Development of detection system of kidney and non-kidney images for different ultrasound machines
by: Shaharuddin, Nurul Aimi
Published: (2020)

The learning curve
by: The Star
Published: (2023)

Improvement Of Curve Construction Using Bi-Qt Bezier Curves And Approximation To Two Types Of Bezier Curves
by: Nordin, Mohamad Ekram
Published: (2024)

Mouse 'plague' cycle
by: Kinsella, John
Published: (2013)