Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats
Lead (Pb) toxicity affects the hepatic and renal systems resulting to homeostasis imbalance. Curcumin is a strong antioxidant but has restrained clinical applications due to its poor bioavailability. Nanomedicine showed promising potentials in drug delivery and has brought forth the use of cockle sh...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88323/ http://psasir.upm.edu.my/id/eprint/88323/1/ABSTRACT.pdf |
| _version_ | 1848860597719924736 |
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| author | Muhammad, Mailafiya Maryam Abubakar, Kabeer Chiroma, Samaila Musa Danmaigoro, Abubakar Abdul Rahim, Ezamin Mohd Moklas, Mohamad Aris Zakaria, Zuki Abu Bakar |
| author_facet | Muhammad, Mailafiya Maryam Abubakar, Kabeer Chiroma, Samaila Musa Danmaigoro, Abubakar Abdul Rahim, Ezamin Mohd Moklas, Mohamad Aris Zakaria, Zuki Abu Bakar |
| author_sort | Muhammad, Mailafiya Maryam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Lead (Pb) toxicity affects the hepatic and renal systems resulting to homeostasis imbalance. Curcumin is a strong antioxidant but has restrained clinical applications due to its poor bioavailability. Nanomedicine showed promising potentials in drug delivery and has brought forth the use of cockle shell-derived aragonite calcium carbonate nanoparticles (CSCaCO3NP) to enhance the effectiveness and targeted delivery of curcumin (Cur). Thus, this study aimed at evaluating the therapeutic effect of curcumin-loaded CSCaCO3NP (Cur- CSCaCO3NP) on lead-induced hepato-renal toxicity in rats. Thirty-six male adults Sprague-Dawley rats were randomly assigned into five groups. All groups contained six rats each except for group A, which contained 12 rats. All rats apart from the rats in group A (control) were orally administered a flat dose of 50 mg/kg of lead for four weeks. Six rats from group A and B were euthanized after four weeks of lead induction. Oral administration of curcumin (100 mg/kg) for group C and Cur-CSCaCO3NP (50 and 100 mg/kg) for groups D and E respectively, commenced immediately after 4 weeks of lead induction which lasted for 4 weeks. All rats were euthanized at the 8th week of the experiment. Further, biochemical, histological and hematological analysis were performed. The findings revealed a biochemical, hematological and histological changes in lead-induced rats. However, treatments with the Cur-CSCaCO3NP and free curcumin reversed the aforementioned changes. Although, Cur-CSCaCO3NP presented better therapeutic effects on lead-induced toxicity in rats when compared to free curcumin as there was significant improvements in hematological, biochemical and histological changes which is parallel with attenuation of oxidative stress. The findings of the current study hold great prospects for Cur-CSCaCO3NP as a novel approach for effective oral treatment of lead-induced hepato-renal impairments. |
| first_indexed | 2025-11-15T12:47:46Z |
| format | Article |
| id | upm-88323 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:47:46Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-883232022-11-24T03:58:21Z http://psasir.upm.edu.my/id/eprint/88323/ Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats Muhammad, Mailafiya Maryam Abubakar, Kabeer Chiroma, Samaila Musa Danmaigoro, Abubakar Abdul Rahim, Ezamin Mohd Moklas, Mohamad Aris Zakaria, Zuki Abu Bakar Lead (Pb) toxicity affects the hepatic and renal systems resulting to homeostasis imbalance. Curcumin is a strong antioxidant but has restrained clinical applications due to its poor bioavailability. Nanomedicine showed promising potentials in drug delivery and has brought forth the use of cockle shell-derived aragonite calcium carbonate nanoparticles (CSCaCO3NP) to enhance the effectiveness and targeted delivery of curcumin (Cur). Thus, this study aimed at evaluating the therapeutic effect of curcumin-loaded CSCaCO3NP (Cur- CSCaCO3NP) on lead-induced hepato-renal toxicity in rats. Thirty-six male adults Sprague-Dawley rats were randomly assigned into five groups. All groups contained six rats each except for group A, which contained 12 rats. All rats apart from the rats in group A (control) were orally administered a flat dose of 50 mg/kg of lead for four weeks. Six rats from group A and B were euthanized after four weeks of lead induction. Oral administration of curcumin (100 mg/kg) for group C and Cur-CSCaCO3NP (50 and 100 mg/kg) for groups D and E respectively, commenced immediately after 4 weeks of lead induction which lasted for 4 weeks. All rats were euthanized at the 8th week of the experiment. Further, biochemical, histological and hematological analysis were performed. The findings revealed a biochemical, hematological and histological changes in lead-induced rats. However, treatments with the Cur-CSCaCO3NP and free curcumin reversed the aforementioned changes. Although, Cur-CSCaCO3NP presented better therapeutic effects on lead-induced toxicity in rats when compared to free curcumin as there was significant improvements in hematological, biochemical and histological changes which is parallel with attenuation of oxidative stress. The findings of the current study hold great prospects for Cur-CSCaCO3NP as a novel approach for effective oral treatment of lead-induced hepato-renal impairments. Elsevier 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88323/1/ABSTRACT.pdf Muhammad, Mailafiya Maryam and Abubakar, Kabeer and Chiroma, Samaila Musa and Danmaigoro, Abubakar and Abdul Rahim, Ezamin and Mohd Moklas, Mohamad Aris and Zakaria, Zuki Abu Bakar (2020) Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats. Saudi Journal of Biological Sciences, 27 (6). 1538 - 1552. ISSN 1319-562X; ESSN: 2213-7106 https://www.sciencedirect.com/science/article/pii/S1319562X20300851 10.1016/j.sjbs.2020.03.009 |
| spellingShingle | Muhammad, Mailafiya Maryam Abubakar, Kabeer Chiroma, Samaila Musa Danmaigoro, Abubakar Abdul Rahim, Ezamin Mohd Moklas, Mohamad Aris Zakaria, Zuki Abu Bakar Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| title | Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| title_full | Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| title_fullStr | Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| title_full_unstemmed | Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| title_short | Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| title_sort | curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a novel strategy for the treatment of lead-induced hepato-renal toxicity in rats |
| url | http://psasir.upm.edu.my/id/eprint/88323/ http://psasir.upm.edu.my/id/eprint/88323/ http://psasir.upm.edu.my/id/eprint/88323/ http://psasir.upm.edu.my/id/eprint/88323/1/ABSTRACT.pdf |