Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy
Platinum drugs are heavily used first-line chemotherapeutic agents for many solid tumours and have stimulated substantial interest in the biological activity of DNA-binding metal complexes. These complexes generate DNA lesions which trigger the activation of DNA damage response (DDR) pathways that a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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John Wiley and Sons
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88194/ http://psasir.upm.edu.my/id/eprint/88194/1/ABSTRACT.pdf |
| _version_ | 1848860574857822208 |
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| author | Yusoh, Nur Aininie Ahmad, Haslina Gill, Martin R. |
| author_facet | Yusoh, Nur Aininie Ahmad, Haslina Gill, Martin R. |
| author_sort | Yusoh, Nur Aininie |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Platinum drugs are heavily used first-line chemotherapeutic agents for many solid tumours and have stimulated substantial interest in the biological activity of DNA-binding metal complexes. These complexes generate DNA lesions which trigger the activation of DNA damage response (DDR) pathways that are essential to maintain genomic integrity. Cancer cells exploit this intrinsic DNA repair network to counteract many types of chemotherapies. Now, advances in the molecular biology of cancer has paved the way for the combination of DDR inhibitors such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) and agents that induce high levels of DNA replication stress or single-strand break damage for synergistic cancer cell killing. In this review, we summarise early-stage, preclinical and clinical findings exploring platinum and emerging ruthenium anti-cancer complexes alongside PARPi in combination therapy for cancer and also describe emerging work on the ability of ruthenium and gold complexes to directly inhibit PARP activity. |
| first_indexed | 2025-11-15T12:47:24Z |
| format | Article |
| id | upm-88194 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:47:24Z |
| publishDate | 2020 |
| publisher | John Wiley and Sons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-881942022-03-10T07:54:35Z http://psasir.upm.edu.my/id/eprint/88194/ Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy Yusoh, Nur Aininie Ahmad, Haslina Gill, Martin R. Platinum drugs are heavily used first-line chemotherapeutic agents for many solid tumours and have stimulated substantial interest in the biological activity of DNA-binding metal complexes. These complexes generate DNA lesions which trigger the activation of DNA damage response (DDR) pathways that are essential to maintain genomic integrity. Cancer cells exploit this intrinsic DNA repair network to counteract many types of chemotherapies. Now, advances in the molecular biology of cancer has paved the way for the combination of DDR inhibitors such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) and agents that induce high levels of DNA replication stress or single-strand break damage for synergistic cancer cell killing. In this review, we summarise early-stage, preclinical and clinical findings exploring platinum and emerging ruthenium anti-cancer complexes alongside PARPi in combination therapy for cancer and also describe emerging work on the ability of ruthenium and gold complexes to directly inhibit PARP activity. John Wiley and Sons 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88194/1/ABSTRACT.pdf Yusoh, Nur Aininie and Ahmad, Haslina and Gill, Martin R. (2020) Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy. ChemMedChem, 15 (22). 2121 - 2135. ISSN 1860-7179; ESSN: 1860-7187 https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202000391 10.1002/cmdc.202000391 |
| spellingShingle | Yusoh, Nur Aininie Ahmad, Haslina Gill, Martin R. Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| title | Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| title_full | Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| title_fullStr | Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| title_full_unstemmed | Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| title_short | Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| title_sort | combining parp inhibition with platinum, ruthenium or gold complexes for cancer therapy |
| url | http://psasir.upm.edu.my/id/eprint/88194/ http://psasir.upm.edu.my/id/eprint/88194/ http://psasir.upm.edu.my/id/eprint/88194/ http://psasir.upm.edu.my/id/eprint/88194/1/ABSTRACT.pdf |