Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles
Colorectal cancer (CRC) is one of the most common cancers with equal probability of affecting both men and women worldwide. Recently, the newly emerged theory of cancer stem cells has associated CRC stem cells (CRCSCs) with the high rates of recurrence and poor prognosis. Thus, targeting CRCSCs inst...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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RSC Publishing
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88189/ http://psasir.upm.edu.my/id/eprint/88189/1/ABSTRACT.pdf |
| _version_ | 1848860574027350016 |
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| author | Mohd Zahid, Manali Haniti Mohamud, Rohimah Che Abdullah, Che Azurahanim Lim, JitKang Alem, Halima Wan Hanaffi, Wan Nurhidayah Z. A., Iskandar |
| author_facet | Mohd Zahid, Manali Haniti Mohamud, Rohimah Che Abdullah, Che Azurahanim Lim, JitKang Alem, Halima Wan Hanaffi, Wan Nurhidayah Z. A., Iskandar |
| author_sort | Mohd Zahid, Manali Haniti |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Colorectal cancer (CRC) is one of the most common cancers with equal probability of affecting both men and women worldwide. Recently, the newly emerged theory of cancer stem cells has associated CRC stem cells (CRCSCs) with the high rates of recurrence and poor prognosis. Thus, targeting CRCSCs instead of CRC may resolve cancer relapse. Among the chemotherapeutic drugs, the antimetabolite 5-fluorouracil (5-FU) has shown high efficiency in CRC treatment. However, due to several limitations, the usefulness of 5-FU has been restricted. The application of gold nanoparticles (AuNPs) in drug delivery systems is reported to enhance the effectiveness of anticancer drugs due to their biostability, non-toxicity and feasibility for surface modification. Furthermore, the overexpression of biomolecular surface markers in CRCSCs may elevate the specific targeting by AuNPs, and hence, reduce the non-specific binding, which could lead to systemic side effects. This review briefly presents the proposed therapeutic potential of AuNPs loaded with 5-FU, conjugated with specific antibodies targeting CRCSCs, which could be valuable to improve some limitations in current CRC management. |
| first_indexed | 2025-11-15T12:47:24Z |
| format | Article |
| id | upm-88189 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:47:24Z |
| publishDate | 2020 |
| publisher | RSC Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-881892022-03-10T07:53:20Z http://psasir.upm.edu.my/id/eprint/88189/ Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles Mohd Zahid, Manali Haniti Mohamud, Rohimah Che Abdullah, Che Azurahanim Lim, JitKang Alem, Halima Wan Hanaffi, Wan Nurhidayah Z. A., Iskandar Colorectal cancer (CRC) is one of the most common cancers with equal probability of affecting both men and women worldwide. Recently, the newly emerged theory of cancer stem cells has associated CRC stem cells (CRCSCs) with the high rates of recurrence and poor prognosis. Thus, targeting CRCSCs instead of CRC may resolve cancer relapse. Among the chemotherapeutic drugs, the antimetabolite 5-fluorouracil (5-FU) has shown high efficiency in CRC treatment. However, due to several limitations, the usefulness of 5-FU has been restricted. The application of gold nanoparticles (AuNPs) in drug delivery systems is reported to enhance the effectiveness of anticancer drugs due to their biostability, non-toxicity and feasibility for surface modification. Furthermore, the overexpression of biomolecular surface markers in CRCSCs may elevate the specific targeting by AuNPs, and hence, reduce the non-specific binding, which could lead to systemic side effects. This review briefly presents the proposed therapeutic potential of AuNPs loaded with 5-FU, conjugated with specific antibodies targeting CRCSCs, which could be valuable to improve some limitations in current CRC management. RSC Publishing 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88189/1/ABSTRACT.pdf Mohd Zahid, Manali Haniti and Mohamud, Rohimah and Che Abdullah, Che Azurahanim and Lim, JitKang and Alem, Halima and Wan Hanaffi, Wan Nurhidayah and Z. A., Iskandar (2020) Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles. RSC Advances, 10 (2). 973 - 985. ISSN 2046-2069 https://pubs.rsc.org/en/content/articlelanding/2020/ra/c9ra08192e 10.1039/C9RA08192E |
| spellingShingle | Mohd Zahid, Manali Haniti Mohamud, Rohimah Che Abdullah, Che Azurahanim Lim, JitKang Alem, Halima Wan Hanaffi, Wan Nurhidayah Z. A., Iskandar Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| title | Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| title_full | Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| title_fullStr | Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| title_full_unstemmed | Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| title_short | Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| title_sort | colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles |
| url | http://psasir.upm.edu.my/id/eprint/88189/ http://psasir.upm.edu.my/id/eprint/88189/ http://psasir.upm.edu.my/id/eprint/88189/ http://psasir.upm.edu.my/id/eprint/88189/1/ABSTRACT.pdf |