Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia
Background: Colorectal cancer is the second most common cancer in Malaysia. Its disease burden is likely to increase over time owing to its current trends in this region. This study was undertaken to determine the 5-year survival rate and prognostic factors for survival in colorectal cancer patients...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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AME Publishing Company
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88173/ http://psasir.upm.edu.my/id/eprint/88173/1/ABSTRACT.pdf |
| _version_ | 1848860570139230208 |
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| author | Lim, Kean Ghee Lee, Chit Seng Hong, Daniel Jeng Chin Ooi, Yong Song Veettil, Sajesh K. Ching, Siew Mooi Burud, Ismail Abdul Sattar Zakaria, Jasiah |
| author_facet | Lim, Kean Ghee Lee, Chit Seng Hong, Daniel Jeng Chin Ooi, Yong Song Veettil, Sajesh K. Ching, Siew Mooi Burud, Ismail Abdul Sattar Zakaria, Jasiah |
| author_sort | Lim, Kean Ghee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Colorectal cancer is the second most common cancer in Malaysia. Its disease burden is likely to increase over time owing to its current trends in this region. This study was undertaken to determine the 5-year survival rate and prognostic factors for survival in colorectal cancer patients treated in a tertiary hospital, in Malaysia. Methods: We reviewed the records of colorectal cancer patients treated in Hospital Tuanku Ja’afar Seremban, Malaysia from 2008 to 2012. Survival analysis at five years was performed using the Kaplan-Meier method. Cox proportional hazard regression analysis was carried out to determine the predictors of 5-year colorectal cancer survival. Results: Of the 275 patients, 43.3% were colon cancers, 51.8% were rectal cancers. Only 2.2% were diagnosed in Stage I. 28.7%, 33.1%, and 16.7% were in Stage II, III and IV respectively; 62/79 (78%) of Stage II patients were in Stage IIb; 15.7% of patients were below the age of 50 and fewer of them presented early (P=0.002). The overall 5-year survival was 46.5%. It was 67.9%, 50.5% and 12.8% for Stage I&II, III and IV patients respectively. Early stage of cancer (P<0.001) and age below the mean (P=0.01) were the most significant factor in predicting better survival. Gender and ethnic group were not associated with late presentation nor survival. Neither was there a difference between colon and rectum cancers nor patients who received elective surgical treatment compared to patients receiving other treatment first (P=0.085). Conclusions: Late presentation is the most important predictor for poor outcome for colorectal cancer in Seremban. Patients under the age of 50 years present late more often, but do not have poorer survival. |
| first_indexed | 2025-11-15T12:47:20Z |
| format | Article |
| id | upm-88173 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:47:20Z |
| publishDate | 2020 |
| publisher | AME Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-881732022-05-18T03:16:31Z http://psasir.upm.edu.my/id/eprint/88173/ Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia Lim, Kean Ghee Lee, Chit Seng Hong, Daniel Jeng Chin Ooi, Yong Song Veettil, Sajesh K. Ching, Siew Mooi Burud, Ismail Abdul Sattar Zakaria, Jasiah Background: Colorectal cancer is the second most common cancer in Malaysia. Its disease burden is likely to increase over time owing to its current trends in this region. This study was undertaken to determine the 5-year survival rate and prognostic factors for survival in colorectal cancer patients treated in a tertiary hospital, in Malaysia. Methods: We reviewed the records of colorectal cancer patients treated in Hospital Tuanku Ja’afar Seremban, Malaysia from 2008 to 2012. Survival analysis at five years was performed using the Kaplan-Meier method. Cox proportional hazard regression analysis was carried out to determine the predictors of 5-year colorectal cancer survival. Results: Of the 275 patients, 43.3% were colon cancers, 51.8% were rectal cancers. Only 2.2% were diagnosed in Stage I. 28.7%, 33.1%, and 16.7% were in Stage II, III and IV respectively; 62/79 (78%) of Stage II patients were in Stage IIb; 15.7% of patients were below the age of 50 and fewer of them presented early (P=0.002). The overall 5-year survival was 46.5%. It was 67.9%, 50.5% and 12.8% for Stage I&II, III and IV patients respectively. Early stage of cancer (P<0.001) and age below the mean (P=0.01) were the most significant factor in predicting better survival. Gender and ethnic group were not associated with late presentation nor survival. Neither was there a difference between colon and rectum cancers nor patients who received elective surgical treatment compared to patients receiving other treatment first (P=0.085). Conclusions: Late presentation is the most important predictor for poor outcome for colorectal cancer in Seremban. Patients under the age of 50 years present late more often, but do not have poorer survival. AME Publishing Company 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88173/1/ABSTRACT.pdf Lim, Kean Ghee and Lee, Chit Seng and Hong, Daniel Jeng Chin and Ooi, Yong Song and Veettil, Sajesh K. and Ching, Siew Mooi and Burud, Ismail Abdul Sattar and Zakaria, Jasiah (2020) Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia. Journal of Gastrointestinal Oncology, 11 (2). 250 - 259. ISSN 2078-6891; ESSN: 2219-679X https://jgo.amegroups.com/article/view/37400/html 10.21037/jgo.2020.02.04 |
| spellingShingle | Lim, Kean Ghee Lee, Chit Seng Hong, Daniel Jeng Chin Ooi, Yong Song Veettil, Sajesh K. Ching, Siew Mooi Burud, Ismail Abdul Sattar Zakaria, Jasiah Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia |
| title | Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia |
| title_full | Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia |
| title_fullStr | Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia |
| title_full_unstemmed | Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia |
| title_short | Clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in Malaysia |
| title_sort | clinical characteristics and predictors of 5-year survival among colorectal cancer patients in a tertiary hospital in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/88173/ http://psasir.upm.edu.my/id/eprint/88173/ http://psasir.upm.edu.my/id/eprint/88173/ http://psasir.upm.edu.my/id/eprint/88173/1/ABSTRACT.pdf |