Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review
1,2-dimethylhydrazine (DMH) is a member in the class of hydrazines, strong DNA alkylating agent, naturally present in cycads. DMH is widely used as a carcinogen to induce colon cancer in animal models. Exploration of DMH-induced colon carcinogenesis in rodent models provides the knowledge to perceiv...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/88023/ http://psasir.upm.edu.my/id/eprint/88023/1/ABSTRACT.pdf |
| _version_ | 1848860539945484288 |
|---|---|
| author | Venkatachalam, Karthikkumar Vinayagam, Ramachandran Anand, Mariadoss Arokia Vijaya Mat Isa, Nurulfiza Ponnaiyan, Rajasekar |
| author_facet | Venkatachalam, Karthikkumar Vinayagam, Ramachandran Anand, Mariadoss Arokia Vijaya Mat Isa, Nurulfiza Ponnaiyan, Rajasekar |
| author_sort | Venkatachalam, Karthikkumar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | 1,2-dimethylhydrazine (DMH) is a member in the class of hydrazines, strong DNA alkylating agent, naturally present in cycads. DMH is widely used as a carcinogen to induce colon cancer in animal models. Exploration of DMH-induced colon carcinogenesis in rodent models provides the knowledge to perceive the biochemical, molecular, and histological mechanisms of different stages of colon carcinogenesis. The procarcinogen DMH, after a series of metabolic reactions, finally reaches the colon, there produces the ultimate carcinogen and reactive oxygen species (ROS), which further alkylate the DNA and initiate the development of colon carcinogenesis. The preneolpastic lesions and histopathological observations of DMH-induced colon tumors may provide typical understanding about the disease in rodents and humans. In addition, this review discusses about the action of biotransformation and antioxidant enzymes involved in DMH intoxication. This understanding is essential to accurately identify and interpret alterations that occur in the colonic mucosa when evaluating natural or pharmacological compounds in DMH-induced animal colon carcinogenesis. |
| first_indexed | 2025-11-15T12:46:51Z |
| format | Article |
| id | upm-88023 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:46:51Z |
| publishDate | 2020 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-880232022-05-24T04:47:47Z http://psasir.upm.edu.my/id/eprint/88023/ Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review Venkatachalam, Karthikkumar Vinayagam, Ramachandran Anand, Mariadoss Arokia Vijaya Mat Isa, Nurulfiza Ponnaiyan, Rajasekar 1,2-dimethylhydrazine (DMH) is a member in the class of hydrazines, strong DNA alkylating agent, naturally present in cycads. DMH is widely used as a carcinogen to induce colon cancer in animal models. Exploration of DMH-induced colon carcinogenesis in rodent models provides the knowledge to perceive the biochemical, molecular, and histological mechanisms of different stages of colon carcinogenesis. The procarcinogen DMH, after a series of metabolic reactions, finally reaches the colon, there produces the ultimate carcinogen and reactive oxygen species (ROS), which further alkylate the DNA and initiate the development of colon carcinogenesis. The preneolpastic lesions and histopathological observations of DMH-induced colon tumors may provide typical understanding about the disease in rodents and humans. In addition, this review discusses about the action of biotransformation and antioxidant enzymes involved in DMH intoxication. This understanding is essential to accurately identify and interpret alterations that occur in the colonic mucosa when evaluating natural or pharmacological compounds in DMH-induced animal colon carcinogenesis. Royal Society of Chemistry 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88023/1/ABSTRACT.pdf Venkatachalam, Karthikkumar and Vinayagam, Ramachandran and Anand, Mariadoss Arokia Vijaya and Mat Isa, Nurulfiza and Ponnaiyan, Rajasekar (2020) Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review. Toxicology Research, 9 (1). pp. 2-18. ISSN 2045-452X; ESSN: 2045-4538 https://academic.oup.com/toxres/article/9/1/2/5813023 10.1093/toxres/tfaa004 |
| spellingShingle | Venkatachalam, Karthikkumar Vinayagam, Ramachandran Anand, Mariadoss Arokia Vijaya Mat Isa, Nurulfiza Ponnaiyan, Rajasekar Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review |
| title | Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review |
| title_full | Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review |
| title_fullStr | Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review |
| title_full_unstemmed | Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review |
| title_short | Biochemical and molecular aspects of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review |
| title_sort | biochemical and molecular aspects of 1,2-dimethylhydrazine (dmh)-induced colon carcinogenesis: a review |
| url | http://psasir.upm.edu.my/id/eprint/88023/ http://psasir.upm.edu.my/id/eprint/88023/ http://psasir.upm.edu.my/id/eprint/88023/ http://psasir.upm.edu.my/id/eprint/88023/1/ABSTRACT.pdf |