Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds
Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87700/ http://psasir.upm.edu.my/id/eprint/87700/1/ABSTRACT.pdf |
| _version_ | 1848860485510758400 |
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| author | Wu, Yong-Xiang You, Jeong Kim Tae, Hyung Kwon Tan, Chin Ping Kun, Ho Son Kim, Taewan |
| author_facet | Wu, Yong-Xiang You, Jeong Kim Tae, Hyung Kwon Tan, Chin Ping Kun, Ho Son Kim, Taewan |
| author_sort | Wu, Yong-Xiang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB. |
| first_indexed | 2025-11-15T12:45:59Z |
| format | Article |
| id | upm-87700 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:45:59Z |
| publishDate | 2020 |
| publisher | Taylor and Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-877002022-07-06T05:02:29Z http://psasir.upm.edu.my/id/eprint/87700/ Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds Wu, Yong-Xiang You, Jeong Kim Tae, Hyung Kwon Tan, Chin Ping Kun, Ho Son Kim, Taewan Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB. Taylor and Francis 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87700/1/ABSTRACT.pdf Wu, Yong-Xiang and You, Jeong Kim and Tae, Hyung Kwon and Tan, Chin Ping and Kun, Ho Son and Kim, Taewan (2020) Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds. Natural Product Research, 34 (12). 1786 - 1790. ISSN 1478-6419; ESSN: 1478-6427 https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1527832?journalCode=gnpl20 10.1080/14786419.2018.1527832 |
| spellingShingle | Wu, Yong-Xiang You, Jeong Kim Tae, Hyung Kwon Tan, Chin Ping Kun, Ho Son Kim, Taewan Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| title | Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| title_full | Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| title_fullStr | Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| title_full_unstemmed | Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| title_short | Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds |
| title_sort | anti-inflammatory effects of mulberry (morus alba l.) root bark and its active compounds |
| url | http://psasir.upm.edu.my/id/eprint/87700/ http://psasir.upm.edu.my/id/eprint/87700/ http://psasir.upm.edu.my/id/eprint/87700/ http://psasir.upm.edu.my/id/eprint/87700/1/ABSTRACT.pdf |