A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis
Sepsis refers to organ failure due to uncontrolled body immune responses towards infection. The systemic inflammatory response triggered by pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, is accompanied by the release of various proinflam...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87657/ http://psasir.upm.edu.my/id/eprint/87657/1/ABSTRACT.pdf |
| _version_ | 1848860477144170496 |
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| author | Liew, Kong Yen Hafiz, Md Faizul Chong, Yi Joong Harith, Hanis Hazeera Israf Ali, Daud Ahmad |
| author_facet | Liew, Kong Yen Hafiz, Md Faizul Chong, Yi Joong Harith, Hanis Hazeera Israf Ali, Daud Ahmad |
| author_sort | Liew, Kong Yen |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Sepsis refers to organ failure due to uncontrolled body immune responses towards infection. The systemic inflammatory response triggered by pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, is accompanied by the release of various proinflammatory mediators that can lead to organ damage. The progression to septic shock is even more life-threatening due to hypotension. Thus, sepsis is a leading cause of death and morbidity globally. However, current therapies are mainly symptomatic treatment and rely on the use of antibiotics. The lack of a specific treatment demands exploration of new drugs. Malaysian herbal plants have a long history of usage for medicinal purposes. A total of 64 Malaysian plants commonly used in the herbal industry have been published in Malaysian Herbal Monograph 2015 and Globinmed website (http://www.globinmed.com/). An extensive bibliographic search in databases such as PubMed, ScienceDirect, and Scopus revealed that seven of these plants have antisepsis properties, as evidenced by the therapeutic effect of their extracts or isolated compounds against sepsis-associated inflammatory responses or conditions in in vitro or/and in vivo studies. These include Andrographis paniculata, Zingiber officinale, Curcuma longa, Piper nigrum, Syzygium aromaticum, Momordica charantia, and Centella asiatica. Among these, Z. officinale is the most widely studied plant and seems to have the highest potential for future therapeutic applications in sepsis. Although both extracts as well as active constituents from these herbal plants have demonstrated potential antisepsis activity, the activity might be primarily contributed by the active constituent(s) from each of these plants, which are andrographolide (A. paniculata), 6-gingerol and zingerone (Z. officinale), curcumin (C. longa), piperine and pellitorine (P. nigrum), biflorin (S. aromaticum), and asiaticoside, asiatic acid, and madecassoside (C. asiatica). These active constituents have shown great antisepsis effects, and further investigations into their clinical therapeutic potential may be worthwhile. |
| first_indexed | 2025-11-15T12:45:51Z |
| format | Article |
| id | upm-87657 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:45:51Z |
| publishDate | 2020 |
| publisher | Hindawi Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-876572022-07-06T08:14:41Z http://psasir.upm.edu.my/id/eprint/87657/ A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis Liew, Kong Yen Hafiz, Md Faizul Chong, Yi Joong Harith, Hanis Hazeera Israf Ali, Daud Ahmad Sepsis refers to organ failure due to uncontrolled body immune responses towards infection. The systemic inflammatory response triggered by pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, is accompanied by the release of various proinflammatory mediators that can lead to organ damage. The progression to septic shock is even more life-threatening due to hypotension. Thus, sepsis is a leading cause of death and morbidity globally. However, current therapies are mainly symptomatic treatment and rely on the use of antibiotics. The lack of a specific treatment demands exploration of new drugs. Malaysian herbal plants have a long history of usage for medicinal purposes. A total of 64 Malaysian plants commonly used in the herbal industry have been published in Malaysian Herbal Monograph 2015 and Globinmed website (http://www.globinmed.com/). An extensive bibliographic search in databases such as PubMed, ScienceDirect, and Scopus revealed that seven of these plants have antisepsis properties, as evidenced by the therapeutic effect of their extracts or isolated compounds against sepsis-associated inflammatory responses or conditions in in vitro or/and in vivo studies. These include Andrographis paniculata, Zingiber officinale, Curcuma longa, Piper nigrum, Syzygium aromaticum, Momordica charantia, and Centella asiatica. Among these, Z. officinale is the most widely studied plant and seems to have the highest potential for future therapeutic applications in sepsis. Although both extracts as well as active constituents from these herbal plants have demonstrated potential antisepsis activity, the activity might be primarily contributed by the active constituent(s) from each of these plants, which are andrographolide (A. paniculata), 6-gingerol and zingerone (Z. officinale), curcumin (C. longa), piperine and pellitorine (P. nigrum), biflorin (S. aromaticum), and asiaticoside, asiatic acid, and madecassoside (C. asiatica). These active constituents have shown great antisepsis effects, and further investigations into their clinical therapeutic potential may be worthwhile. Hindawi Publishing 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/87657/1/ABSTRACT.pdf Liew, Kong Yen and Hafiz, Md Faizul and Chong, Yi Joong and Harith, Hanis Hazeera and Israf Ali, Daud Ahmad (2020) A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis. Evidence-based Complementary and Alternative Medicine, 2020. art. no. 8257817. pp. 1-20. ISSN 1741-427X; ESSN: 1741-4288 https://www.hindawi.com/journals/ecam/2020/8257817/ 10.1155/2020/8257817 |
| spellingShingle | Liew, Kong Yen Hafiz, Md Faizul Chong, Yi Joong Harith, Hanis Hazeera Israf Ali, Daud Ahmad A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| title | A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| title_full | A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| title_fullStr | A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| title_full_unstemmed | A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| title_short | A review of Malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| title_sort | review of malaysian herbal plants and their active constituents with potential therapeutic applications in sepsis |
| url | http://psasir.upm.edu.my/id/eprint/87657/ http://psasir.upm.edu.my/id/eprint/87657/ http://psasir.upm.edu.my/id/eprint/87657/ http://psasir.upm.edu.my/id/eprint/87657/1/ABSTRACT.pdf |