Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases
Infectious diseases are the ever-present threats to public health and the global economy. Accurate and timely diagnosis is crucial to impede the progression of a disease and break the chain of transmission. Conventional diagnostic techniques are typically time-consuming and costly, making them ineff...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Elsevier
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87386/ |
| _version_ | 1848860431200813056 |
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| author | Lim, Hui Lim Saha, Tridib Beng, Ti Tey Wen, Siang Tan Chien, Wei Ooi |
| author_facet | Lim, Hui Lim Saha, Tridib Beng, Ti Tey Wen, Siang Tan Chien, Wei Ooi |
| author_sort | Lim, Hui Lim |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Infectious diseases are the ever-present threats to public health and the global economy. Accurate and timely diagnosis is crucial to impede the progression of a disease and break the chain of transmission. Conventional diagnostic techniques are typically time-consuming and costly, making them inefficient for early diagnosis of infections and inconvenient for use at the point of care. Developments of sensitive, rapid, and affordable diagnostic methods are necessary to improve the clinical management of infectious diseases. Quartz crystal microbalance (QCM) systems have emerged as a robust biosensing platform due to their label-free mechanism, which allows the detection and quantification of a wide range of biomolecules. The high sensitivity and short detection time offered by QCM-based biosensors are attractive for the early detection of infections and the routine monitoring of disease progression. Herein, the strategies employed in QCM-based biosensors for the detection of infectious diseases are extensively reviewed, with a focus on prevalent diseases for which improved diagnostic techniques are in high demand. The challenges to the clinical application of QCM-based biosensors are highlighted, along with an outline of the future scope of research in QCM-based diagnostics. |
| first_indexed | 2025-11-15T12:45:07Z |
| format | Article |
| id | upm-87386 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T12:45:07Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-873862023-09-18T03:34:14Z http://psasir.upm.edu.my/id/eprint/87386/ Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases Lim, Hui Lim Saha, Tridib Beng, Ti Tey Wen, Siang Tan Chien, Wei Ooi Infectious diseases are the ever-present threats to public health and the global economy. Accurate and timely diagnosis is crucial to impede the progression of a disease and break the chain of transmission. Conventional diagnostic techniques are typically time-consuming and costly, making them inefficient for early diagnosis of infections and inconvenient for use at the point of care. Developments of sensitive, rapid, and affordable diagnostic methods are necessary to improve the clinical management of infectious diseases. Quartz crystal microbalance (QCM) systems have emerged as a robust biosensing platform due to their label-free mechanism, which allows the detection and quantification of a wide range of biomolecules. The high sensitivity and short detection time offered by QCM-based biosensors are attractive for the early detection of infections and the routine monitoring of disease progression. Herein, the strategies employed in QCM-based biosensors for the detection of infectious diseases are extensively reviewed, with a focus on prevalent diseases for which improved diagnostic techniques are in high demand. The challenges to the clinical application of QCM-based biosensors are highlighted, along with an outline of the future scope of research in QCM-based diagnostics. Elsevier 2020-11-15 Article PeerReviewed Lim, Hui Lim and Saha, Tridib and Beng, Ti Tey and Wen, Siang Tan and Chien, Wei Ooi (2020) Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases. Biosensors and Bioelectronics, 168. art. no. 112513. pp. 1-15. ISSN 0956-5663; ESSN: 1873-4235 https://www.sciencedirect.com/journal/biosensors-and-bioelectronics 10.1016/j.bios.2020.112513 |
| spellingShingle | Lim, Hui Lim Saha, Tridib Beng, Ti Tey Wen, Siang Tan Chien, Wei Ooi Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| title | Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| title_full | Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| title_fullStr | Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| title_full_unstemmed | Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| title_short | Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| title_sort | quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases |
| url | http://psasir.upm.edu.my/id/eprint/87386/ http://psasir.upm.edu.my/id/eprint/87386/ http://psasir.upm.edu.my/id/eprint/87386/ |