Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability
Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammat...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Dove Press
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87139/ |
| _version_ | 1848860370247090176 |
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| author | Mohd Zaffarin, Anis Syauqina Shiow, Fern Ng Ng, Min Hwei Hassan, Haniza Alias, Ekram |
| author_facet | Mohd Zaffarin, Anis Syauqina Shiow, Fern Ng Ng, Min Hwei Hassan, Haniza Alias, Ekram |
| author_sort | Mohd Zaffarin, Anis Syauqina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. However, the poor bioavailability of vitamin E, especially tocotrienols, remains a great limitation for clinical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. This review focuses on the pharmacological properties and pharmacokinetics of vitamin E and current advances in vitamin E nanoformulations for future clinical applications. The limitations and future recommendations are also discussed in this review. |
| first_indexed | 2025-11-15T12:44:09Z |
| format | Article |
| id | upm-87139 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T12:44:09Z |
| publishDate | 2020 |
| publisher | Dove Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-871392023-01-25T08:36:29Z http://psasir.upm.edu.my/id/eprint/87139/ Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability Mohd Zaffarin, Anis Syauqina Shiow, Fern Ng Ng, Min Hwei Hassan, Haniza Alias, Ekram Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups, tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although vitamin E is widely known as a potent antioxidant, studies have also revealed that vitamin E possesses anti-inflammatory properties. These crucial properties of vitamin E are beneficial in various aspects of health, especially in neuroprotection and cardiovascular, skin and bone health. However, the poor bioavailability of vitamin E, especially tocotrienols, remains a great limitation for clinical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. This review focuses on the pharmacological properties and pharmacokinetics of vitamin E and current advances in vitamin E nanoformulations for future clinical applications. The limitations and future recommendations are also discussed in this review. Dove Press 2020-12-08 Article PeerReviewed Mohd Zaffarin, Anis Syauqina and Shiow, Fern Ng and Ng, Min Hwei and Hassan, Haniza and Alias, Ekram (2020) Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability. International Journal of Nanomedicine, 2020 (15). 9961 - 9974. ISSN 1176-9114 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733471/ 10.2147/IJN.S276355 |
| spellingShingle | Mohd Zaffarin, Anis Syauqina Shiow, Fern Ng Ng, Min Hwei Hassan, Haniza Alias, Ekram Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability |
| title | Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability |
| title_full | Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability |
| title_fullStr | Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability |
| title_full_unstemmed | Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability |
| title_short | Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability |
| title_sort | pharmacology and pharmacokinetics of vitamin e: nanoformulations to enhance bioavailability |
| url | http://psasir.upm.edu.my/id/eprint/87139/ http://psasir.upm.edu.my/id/eprint/87139/ http://psasir.upm.edu.my/id/eprint/87139/ |