Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice
The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline loaded cockle shell calcium carbonate-based nano...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
Frontiers
2020
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/87138/ |
| _version_ | 1848860369946148864 |
|---|---|
| author | Idris, Sherifat Banke Abdul Kadir, Arifah Abdullah, Jesse F. F. Ramanoon, Siti-Zubaidah Abdul Basit, Muhammad Abubakar, Md Zuki Z. A. |
| author_facet | Idris, Sherifat Banke Abdul Kadir, Arifah Abdullah, Jesse F. F. Ramanoon, Siti-Zubaidah Abdul Basit, Muhammad Abubakar, Md Zuki Z. A. |
| author_sort | Idris, Sherifat Banke |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle (OTC-CNP) after a single dose of intraperitoneal (IP) administration in BALB/c mice. A total of 100 female BALB/c mice divided into two groups of equal number (n = 50) were administered with 10 mg/kg OTC and OTC-CNP, respectively. Blood samples were collected before and post-administration from both groups at time 0, 5, 10, 15, and 30 min and 1, 2, 6, 24, and 48 h, and OTC plasma concentration was quantified using a validated HPLC-UV method. The pharmacokinetic parameters were analyzed using a non-compartment model. The Cmax values of OTC in OTC-CNP and free OTC treated group were 64.99 and 23.53 μg/ml, respectively. OTC was detected up to 24 h in the OTC-CNP group as against 1 h in the free OTC group following intraperitoneal administration. In the OTC-CNP group, the plasma elimination rate of OTC was slower while the half-life, the area under the curve, and the volume of the distribution were increased. In conclusion, the pharmacokinetic profile of OTC in the OTC-CNP group differs significantly from that of free OTC. However, further studies are necessary to determine the antibacterial efficacy of OTC-CNP for the treatment of bacterial diseases. |
| first_indexed | 2025-11-15T12:44:09Z |
| format | Article |
| id | upm-87138 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T12:44:09Z |
| publishDate | 2020 |
| publisher | Frontiers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-871382024-05-08T03:49:06Z http://psasir.upm.edu.my/id/eprint/87138/ Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice Idris, Sherifat Banke Abdul Kadir, Arifah Abdullah, Jesse F. F. Ramanoon, Siti-Zubaidah Abdul Basit, Muhammad Abubakar, Md Zuki Z. A. The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle (OTC-CNP) after a single dose of intraperitoneal (IP) administration in BALB/c mice. A total of 100 female BALB/c mice divided into two groups of equal number (n = 50) were administered with 10 mg/kg OTC and OTC-CNP, respectively. Blood samples were collected before and post-administration from both groups at time 0, 5, 10, 15, and 30 min and 1, 2, 6, 24, and 48 h, and OTC plasma concentration was quantified using a validated HPLC-UV method. The pharmacokinetic parameters were analyzed using a non-compartment model. The Cmax values of OTC in OTC-CNP and free OTC treated group were 64.99 and 23.53 μg/ml, respectively. OTC was detected up to 24 h in the OTC-CNP group as against 1 h in the free OTC group following intraperitoneal administration. In the OTC-CNP group, the plasma elimination rate of OTC was slower while the half-life, the area under the curve, and the volume of the distribution were increased. In conclusion, the pharmacokinetic profile of OTC in the OTC-CNP group differs significantly from that of free OTC. However, further studies are necessary to determine the antibacterial efficacy of OTC-CNP for the treatment of bacterial diseases. Frontiers 2020-06 Article PeerReviewed Idris, Sherifat Banke and Abdul Kadir, Arifah and Abdullah, Jesse F. F. and Ramanoon, Siti-Zubaidah and Abdul Basit, Muhammad and Abubakar, Md Zuki Z. A. (2020) Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice. Frontiers in Veterinary Science, 7. pp. 1-5. ISSN 2297-1769 https://www.frontiersin.org/articles/10.3389/fvets.2020.00270/full 10.3389/fvets.2020.00270 |
| spellingShingle | Idris, Sherifat Banke Abdul Kadir, Arifah Abdullah, Jesse F. F. Ramanoon, Siti-Zubaidah Abdul Basit, Muhammad Abubakar, Md Zuki Z. A. Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice |
| title | Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice |
| title_full | Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice |
| title_fullStr | Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice |
| title_full_unstemmed | Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice |
| title_short | Pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in BALB/c Mice |
| title_sort | pharmacokinetics of free oxytetracycline and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle in balb/c mice |
| url | http://psasir.upm.edu.my/id/eprint/87138/ http://psasir.upm.edu.my/id/eprint/87138/ http://psasir.upm.edu.my/id/eprint/87138/ |