Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia
Introduction: Invasive pneumococcal disease (IPD) a leading cause of death and morbidity in children below five-yearsold. This study aims to compare the varied presentation and clinical course of IPD in two different tertiary hospitals in Malaysia. Methodology: A retrospective study of all positive...
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| Format: | Article |
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Malaysian Medical Association
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87044/ |
| _version_ | 1848860351764889600 |
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| author | Rengasamy, Sithra Nachiappan, Jeyaseelan Borhan, Rohaizah Othman, Norlijah |
| author_facet | Rengasamy, Sithra Nachiappan, Jeyaseelan Borhan, Rohaizah Othman, Norlijah |
| author_sort | Rengasamy, Sithra |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Invasive pneumococcal disease (IPD) a leading cause of death and morbidity in children below five-yearsold. This study aims to compare the varied presentation and clinical course of IPD in two different tertiary hospitals in Malaysia. Methodology: A retrospective study of all positive Streptococcus pneumoniae isolates consistent with invasive disease from children below 14 years of age hospitalised in two tertiary hospitals; between year 2012 and 2016 was conducted. IPD cases were defined as isolates of S. pneumoniae from a normally sterile body fluid site. Results: Fifty-four patients were identified in both centres, 35 (65%) from HRPB as compared to 19 (35%) from HS. Majority of cases (14/35, 40 %) in HRPB were of Orang Asli in comparison to Malay children (16/19, 84%) in HS. Septicaemia, pneumonia and meningitis were the most common clinical presentation of IPD in both centres. There was a noticeably higher percentage of isolates found to be non-susceptible (NS) in HS (62.5%) as compared to HRPB (37.5%) although of no statistical significance. Mortality rate was higher in HRPB (26%) in comparison to 11% in HS. Conclusion: This study highlighted the varied presentation of IPD in two different hospital settings. Although both deemed as urban centres, this study emphasises the importance of understanding socio-demography, health facility availability and primary care practices as it significantly alters the clinical course of a disease. |
| first_indexed | 2025-11-15T12:43:52Z |
| format | Article |
| id | upm-87044 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T12:43:52Z |
| publishDate | 2020 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-870442023-04-04T02:17:18Z http://psasir.upm.edu.my/id/eprint/87044/ Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia Rengasamy, Sithra Nachiappan, Jeyaseelan Borhan, Rohaizah Othman, Norlijah Introduction: Invasive pneumococcal disease (IPD) a leading cause of death and morbidity in children below five-yearsold. This study aims to compare the varied presentation and clinical course of IPD in two different tertiary hospitals in Malaysia. Methodology: A retrospective study of all positive Streptococcus pneumoniae isolates consistent with invasive disease from children below 14 years of age hospitalised in two tertiary hospitals; between year 2012 and 2016 was conducted. IPD cases were defined as isolates of S. pneumoniae from a normally sterile body fluid site. Results: Fifty-four patients were identified in both centres, 35 (65%) from HRPB as compared to 19 (35%) from HS. Majority of cases (14/35, 40 %) in HRPB were of Orang Asli in comparison to Malay children (16/19, 84%) in HS. Septicaemia, pneumonia and meningitis were the most common clinical presentation of IPD in both centres. There was a noticeably higher percentage of isolates found to be non-susceptible (NS) in HS (62.5%) as compared to HRPB (37.5%) although of no statistical significance. Mortality rate was higher in HRPB (26%) in comparison to 11% in HS. Conclusion: This study highlighted the varied presentation of IPD in two different hospital settings. Although both deemed as urban centres, this study emphasises the importance of understanding socio-demography, health facility availability and primary care practices as it significantly alters the clinical course of a disease. Malaysian Medical Association 2020-01 Article PeerReviewed Rengasamy, Sithra and Nachiappan, Jeyaseelan and Borhan, Rohaizah and Othman, Norlijah (2020) Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia. Medical Journal of Malaysia, 75 (1). 57 - 61. ISSN 0300-5283 https://www.e-mjm.org/ |
| spellingShingle | Rengasamy, Sithra Nachiappan, Jeyaseelan Borhan, Rohaizah Othman, Norlijah Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia |
| title | Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia |
| title_full | Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia |
| title_fullStr | Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia |
| title_full_unstemmed | Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia |
| title_short | Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia |
| title_sort | paediatric invasive pneumococcal disease from two tertiary hospitals in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/87044/ http://psasir.upm.edu.my/id/eprint/87044/ |