One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives
In the current study, a green, one-pot, three-component reaction was performed to prepare novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction of a ketene S,S-acetal of Meldrum’s acid or barbituric acid (as key intermediates), hydrazine, and iso...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bentham Science
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86982/ http://psasir.upm.edu.my/id/eprint/86982/1/One-pot%20green%20synthesis.pdf |
| _version_ | 1848860336147398656 |
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| author | Habibi, Azizollah Khosravi, Sahar Seyyed, Mohammad Shahcheragh Abdul Rahman, Mohd Basyaruddin |
| author_facet | Habibi, Azizollah Khosravi, Sahar Seyyed, Mohammad Shahcheragh Abdul Rahman, Mohd Basyaruddin |
| author_sort | Habibi, Azizollah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In the current study, a green, one-pot, three-component reaction was performed to prepare novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction of a ketene S,S-acetal of Meldrum’s acid or barbituric acid (as key intermediates), hydrazine, and isothiocyanate. The key advantages of this manner include environmentally safe reactions, high yield, appropriate reaction time, simple reaction conditions, and use of a green reaction solvent. The structure of thiadiazoles was determined based on the spectroscopic data. |
| first_indexed | 2025-11-15T12:43:37Z |
| format | Article |
| id | upm-86982 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:43:37Z |
| publishDate | 2020 |
| publisher | Bentham Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-869822022-01-10T08:12:56Z http://psasir.upm.edu.my/id/eprint/86982/ One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives Habibi, Azizollah Khosravi, Sahar Seyyed, Mohammad Shahcheragh Abdul Rahman, Mohd Basyaruddin In the current study, a green, one-pot, three-component reaction was performed to prepare novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction of a ketene S,S-acetal of Meldrum’s acid or barbituric acid (as key intermediates), hydrazine, and isothiocyanate. The key advantages of this manner include environmentally safe reactions, high yield, appropriate reaction time, simple reaction conditions, and use of a green reaction solvent. The structure of thiadiazoles was determined based on the spectroscopic data. Bentham Science 2020-09-25 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86982/1/One-pot%20green%20synthesis.pdf Habibi, Azizollah and Khosravi, Sahar and Seyyed, Mohammad Shahcheragh and Abdul Rahman, Mohd Basyaruddin (2020) One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives. Letters in Organic Chemistry, 17 (7). 517 - 522. ISSN 1570-1786; ESSN: 1875-6255 https://www.eurekaselect.com/175139/article 10.2174/1570178616666190926105533 |
| spellingShingle | Habibi, Azizollah Khosravi, Sahar Seyyed, Mohammad Shahcheragh Abdul Rahman, Mohd Basyaruddin One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| title | One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| title_full | One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| title_fullStr | One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| title_full_unstemmed | One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| title_short | One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| title_sort | one-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives |
| url | http://psasir.upm.edu.my/id/eprint/86982/ http://psasir.upm.edu.my/id/eprint/86982/ http://psasir.upm.edu.my/id/eprint/86982/ http://psasir.upm.edu.my/id/eprint/86982/1/One-pot%20green%20synthesis.pdf |