Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae

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Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae

Meropenem-vaborbactam resistance in Klebsiella pneumoniae isolates is associated with loss-of-function mutations in the OmpK35 and OmpK36 porins. We identify two previously unknown loss-of-function mutations that confer cefuroxime resistance in K. pneumoniae isolates. The proteins lost were NlpD and...

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Bibliographic Details
Main Authors:	Dulyayangkul, Punyawee, Wan Ahmad Kamil, Wan Nur Ismah, Douglas, Edward J. A., Avison, Matthew B.
Format:	Article
Language:	English
Published:	American Society for Microbiology 2020
Online Access:	http://psasir.upm.edu.my/id/eprint/86868/ http://psasir.upm.edu.my/id/eprint/86868/1/Mutation%20of%20kvrA%20causes.pdf

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