Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae
Meropenem-vaborbactam resistance in Klebsiella pneumoniae isolates is associated with loss-of-function mutations in the OmpK35 and OmpK36 porins. We identify two previously unknown loss-of-function mutations that confer cefuroxime resistance in K. pneumoniae isolates. The proteins lost were NlpD and...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86868/ http://psasir.upm.edu.my/id/eprint/86868/1/Mutation%20of%20kvrA%20causes.pdf |
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| author | Dulyayangkul, Punyawee Wan Ahmad Kamil, Wan Nur Ismah Douglas, Edward J. A. Avison, Matthew B. |
| author_facet | Dulyayangkul, Punyawee Wan Ahmad Kamil, Wan Nur Ismah Douglas, Edward J. A. Avison, Matthew B. |
| author_sort | Dulyayangkul, Punyawee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Meropenem-vaborbactam resistance in Klebsiella pneumoniae isolates is associated with loss-of-function mutations in the OmpK35 and OmpK36 porins. We identify two previously unknown loss-of-function mutations that confer cefuroxime resistance in K. pneumoniae isolates. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor that controls capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem-vaborbactam in a KPC-3-producing K. pneumoniae isolate. |
| first_indexed | 2025-11-15T12:43:10Z |
| format | Article |
| id | upm-86868 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:43:10Z |
| publishDate | 2020 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-868682021-12-29T04:14:54Z http://psasir.upm.edu.my/id/eprint/86868/ Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae Dulyayangkul, Punyawee Wan Ahmad Kamil, Wan Nur Ismah Douglas, Edward J. A. Avison, Matthew B. Meropenem-vaborbactam resistance in Klebsiella pneumoniae isolates is associated with loss-of-function mutations in the OmpK35 and OmpK36 porins. We identify two previously unknown loss-of-function mutations that confer cefuroxime resistance in K. pneumoniae isolates. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor that controls capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem-vaborbactam in a KPC-3-producing K. pneumoniae isolate. American Society for Microbiology 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86868/1/Mutation%20of%20kvrA%20causes.pdf Dulyayangkul, Punyawee and Wan Ahmad Kamil, Wan Nur Ismah and Douglas, Edward J. A. and Avison, Matthew B. (2020) Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 64 (7). pp. 1-8. ISSN 0066-4804; ESSN: 1098-6596 https://journals.asm.org/doi/10.1128/AAC.02208-19 10.1128/AAC.02208-19 |
| spellingShingle | Dulyayangkul, Punyawee Wan Ahmad Kamil, Wan Nur Ismah Douglas, Edward J. A. Avison, Matthew B. Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae |
| title | Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae |
| title_full | Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae |
| title_fullStr | Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae |
| title_full_unstemmed | Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae |
| title_short | Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae |
| title_sort | mutation of kvra causes ompk35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in kpc-producing klebsiella pneumoniae |
| url | http://psasir.upm.edu.my/id/eprint/86868/ http://psasir.upm.edu.my/id/eprint/86868/ http://psasir.upm.edu.my/id/eprint/86868/ http://psasir.upm.edu.my/id/eprint/86868/1/Mutation%20of%20kvrA%20causes.pdf |