Multiple corticosteroids allergy in a patient with asthma: a case report
Background: Allergy towards systemic corticosteroid is rare. This case report discusses the investigations to confirm diagnosis and alternative treatments. Case presentation: A 51-year-old asthmatic woman developed severe anaphylactic reaction following administration of systemic hydrocortisone. Ski...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Springer
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86858/ http://psasir.upm.edu.my/id/eprint/86858/1/Modification%20of%20cellulose%20degree%20of%20polymerization%20%281%29.pdf |
| _version_ | 1848860305663197184 |
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| author | Mahadi, Mahrunissa Wan Ahmad Kammal, Wan Syazween Lyana Md Nor, Norazirah Jamil, Adawiyah |
| author_facet | Mahadi, Mahrunissa Wan Ahmad Kammal, Wan Syazween Lyana Md Nor, Norazirah Jamil, Adawiyah |
| author_sort | Mahadi, Mahrunissa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Allergy towards systemic corticosteroid is rare. This case report discusses the investigations to confirm diagnosis and alternative treatments. Case presentation: A 51-year-old asthmatic woman developed severe anaphylactic reaction following administration of systemic hydrocortisone. Skin prick, intradermal, and intravenous provocation tests confirmed allergy to triamcinolone, hydrocortisone, and dexamethasone. Skin prick tests (SPTs) were negative to all the aforementioned drugs. Intradermal test (IDT) with triamcinolone 1:10 concentration resulted in a 2-mm wheal associated with rhonchi. IDT with hydrocortisone 1:10 concentration showed an 8-mm wheal with rhonchi. IDTs to dexamethasone and carboxymethylcellulose were negative. Generalized rhonchi were observed with intravenous dexamethasone full concentration challenge. Conclusions: Corticosteroid allergy should be suspected in asthma patients with worsening bronchospasm after its administration. Due to its rarity, such diagnosis can easily be missed, resulting in increased morbidity and mortality in patients. |
| first_indexed | 2025-11-15T12:43:08Z |
| format | Article |
| id | upm-86858 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:43:08Z |
| publishDate | 2020 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-868582021-11-22T02:37:47Z http://psasir.upm.edu.my/id/eprint/86858/ Multiple corticosteroids allergy in a patient with asthma: a case report Mahadi, Mahrunissa Wan Ahmad Kammal, Wan Syazween Lyana Md Nor, Norazirah Jamil, Adawiyah Background: Allergy towards systemic corticosteroid is rare. This case report discusses the investigations to confirm diagnosis and alternative treatments. Case presentation: A 51-year-old asthmatic woman developed severe anaphylactic reaction following administration of systemic hydrocortisone. Skin prick, intradermal, and intravenous provocation tests confirmed allergy to triamcinolone, hydrocortisone, and dexamethasone. Skin prick tests (SPTs) were negative to all the aforementioned drugs. Intradermal test (IDT) with triamcinolone 1:10 concentration resulted in a 2-mm wheal associated with rhonchi. IDT with hydrocortisone 1:10 concentration showed an 8-mm wheal with rhonchi. IDTs to dexamethasone and carboxymethylcellulose were negative. Generalized rhonchi were observed with intravenous dexamethasone full concentration challenge. Conclusions: Corticosteroid allergy should be suspected in asthma patients with worsening bronchospasm after its administration. Due to its rarity, such diagnosis can easily be missed, resulting in increased morbidity and mortality in patients. Springer 2020-08-25 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86858/1/Modification%20of%20cellulose%20degree%20of%20polymerization%20%281%29.pdf Mahadi, Mahrunissa and Wan Ahmad Kammal, Wan Syazween Lyana and Md Nor, Norazirah and Jamil, Adawiyah (2020) Multiple corticosteroids allergy in a patient with asthma: a case report. The Egyptian Journal of Internal Medicine, 32. art. no. 4. pp. 1-3. ISSN 1110-7782; ESSN: 2090-9098 https://ejim.springeropen.com/articles/10.1186/s43162-020-00008-x 10.1186/s43162-020-00008-x |
| spellingShingle | Mahadi, Mahrunissa Wan Ahmad Kammal, Wan Syazween Lyana Md Nor, Norazirah Jamil, Adawiyah Multiple corticosteroids allergy in a patient with asthma: a case report |
| title | Multiple corticosteroids allergy in a patient with asthma: a case report |
| title_full | Multiple corticosteroids allergy in a patient with asthma: a case report |
| title_fullStr | Multiple corticosteroids allergy in a patient with asthma: a case report |
| title_full_unstemmed | Multiple corticosteroids allergy in a patient with asthma: a case report |
| title_short | Multiple corticosteroids allergy in a patient with asthma: a case report |
| title_sort | multiple corticosteroids allergy in a patient with asthma: a case report |
| url | http://psasir.upm.edu.my/id/eprint/86858/ http://psasir.upm.edu.my/id/eprint/86858/ http://psasir.upm.edu.my/id/eprint/86858/ http://psasir.upm.edu.my/id/eprint/86858/1/Modification%20of%20cellulose%20degree%20of%20polymerization%20%281%29.pdf |