Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery
Vaginal drug delivery is regarded as a promising route against women-related health issues such as unwanted pregnancies and sexually transmitted infections. However, only a very few studies have been reported on the use of hydrogel rings with low cytotoxicity for vaginal drug delivery applications....
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| Format: | Article |
| Language: | English |
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Elsevier
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86827/ http://psasir.upm.edu.my/id/eprint/86827/1/Montmorillonite.pdf |
| _version_ | 1848860297293463552 |
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| author | Sharifzadeh, Ghorbanali Hezaveh, Hadi Muhamad, Ida Idayu Hashim, Shahrir Khairuddin, Nozieana |
| author_facet | Sharifzadeh, Ghorbanali Hezaveh, Hadi Muhamad, Ida Idayu Hashim, Shahrir Khairuddin, Nozieana |
| author_sort | Sharifzadeh, Ghorbanali |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Vaginal drug delivery is regarded as a promising route against women-related health issues such as unwanted pregnancies and sexually transmitted infections. However, only a very few studies have been reported on the use of hydrogel rings with low cytotoxicity for vaginal drug delivery applications. Moreover, the effect of nanoparticles on hydrogel vaginal rings has not been clearly evaluated. To overcome these challenges, we hereby developed nanocomposite hydrogel rings based on polyacrylamide-sodium carboxymethyl cellulose-montmorillonite nanoparticles in the ring-shaped aluminum mold for controlled drug delivery. The hydrogel rings were synthesized by using N,N′-methylene bisacrylamide, N,N,N′,N′-tetramethyl ethylene diamine, and ammonium persulfate, as a crosslinker, accelerator, and initiator, respectively. The obtained rings were 5.5 cm in diameters and 0.5 cm in rims. Chemical structures of the nanocomposite rings were confirmed by Fourier transform infrared, and Nuclear Magnetic Resonance spectroscopies. Additionally, the swelling ratio of hydrogels was appeared to be adjusted by the introduction of nanoparticles. In vitro release experiment of methylene blue, as a hydrophilic model drug, revealed that the nanocomposite rings could not only reduce burst effect (almost more than twice), but also achieve prolonged release for 15 days in the vaginal fluid simulant which mimic the vaginal conditions at pH of almost 4.2, and a temperature of 37 °C. Importantly, the resultant hydrogel rings with or without various concentrations of montmorillonite showed low cytotoxicity toward human skin fibroblasts. Furthermore, different antibacterial activities against Escherichia coli were observed for various concentrations of montmorillonite in hydrogels. These results suggest |
| first_indexed | 2025-11-15T12:43:00Z |
| format | Article |
| id | upm-86827 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:43:00Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-868272021-11-19T10:08:10Z http://psasir.upm.edu.my/id/eprint/86827/ Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery Sharifzadeh, Ghorbanali Hezaveh, Hadi Muhamad, Ida Idayu Hashim, Shahrir Khairuddin, Nozieana Vaginal drug delivery is regarded as a promising route against women-related health issues such as unwanted pregnancies and sexually transmitted infections. However, only a very few studies have been reported on the use of hydrogel rings with low cytotoxicity for vaginal drug delivery applications. Moreover, the effect of nanoparticles on hydrogel vaginal rings has not been clearly evaluated. To overcome these challenges, we hereby developed nanocomposite hydrogel rings based on polyacrylamide-sodium carboxymethyl cellulose-montmorillonite nanoparticles in the ring-shaped aluminum mold for controlled drug delivery. The hydrogel rings were synthesized by using N,N′-methylene bisacrylamide, N,N,N′,N′-tetramethyl ethylene diamine, and ammonium persulfate, as a crosslinker, accelerator, and initiator, respectively. The obtained rings were 5.5 cm in diameters and 0.5 cm in rims. Chemical structures of the nanocomposite rings were confirmed by Fourier transform infrared, and Nuclear Magnetic Resonance spectroscopies. Additionally, the swelling ratio of hydrogels was appeared to be adjusted by the introduction of nanoparticles. In vitro release experiment of methylene blue, as a hydrophilic model drug, revealed that the nanocomposite rings could not only reduce burst effect (almost more than twice), but also achieve prolonged release for 15 days in the vaginal fluid simulant which mimic the vaginal conditions at pH of almost 4.2, and a temperature of 37 °C. Importantly, the resultant hydrogel rings with or without various concentrations of montmorillonite showed low cytotoxicity toward human skin fibroblasts. Furthermore, different antibacterial activities against Escherichia coli were observed for various concentrations of montmorillonite in hydrogels. These results suggest Elsevier 2020-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86827/1/Montmorillonite.pdf Sharifzadeh, Ghorbanali and Hezaveh, Hadi and Muhamad, Ida Idayu and Hashim, Shahrir and Khairuddin, Nozieana (2020) Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery. Materials Science & Engineering C-Materials for Biological Applications, 110. art. no. 110609. pp. 1-12. ISSN 0928-4931 https://www.sciencedirect.com/science/article/abs/pii/S0928493119317503 10.1016/j.msec.2019.110609 |
| spellingShingle | Sharifzadeh, Ghorbanali Hezaveh, Hadi Muhamad, Ida Idayu Hashim, Shahrir Khairuddin, Nozieana Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| title | Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| title_full | Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| title_fullStr | Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| title_full_unstemmed | Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| title_short | Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| title_sort | montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery |
| url | http://psasir.upm.edu.my/id/eprint/86827/ http://psasir.upm.edu.my/id/eprint/86827/ http://psasir.upm.edu.my/id/eprint/86827/ http://psasir.upm.edu.my/id/eprint/86827/1/Montmorillonite.pdf |