Metallointercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition

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Metallointercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition

There is a need to improve and extend the use of clinically approved poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi), including for BRCA wild-type triple-negative breast cancer (TNBC). The demonstration that ruthenium(II) polypyridyl complex (RPC) metallointercalators can rapidly stall DNA rep...

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Bibliographic Details
Main Authors:	Yusoh, Nur Aininie, Leong, Sze Wei, Chia, Suet Lin, Harun, Siti Norain, Abdul Rahman, Mohd Basyaruddin, Vallis, Katherine A., Gill, Martin R., Ahmad, Haslina
Format:	Article
Language:	English
Published:	American Chemical Society 2020
Online Access:	http://psasir.upm.edu.my/id/eprint/86732/ http://psasir.upm.edu.my/id/eprint/86732/1/Metallointercalator.pdf

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