Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples
This work describes the development of a new methodology based on magnetic nanoparticles assisted dispersive liquid–liquid microextraction (DLLME-MNPs) for preconcentration and extraction of chloramphenicol (CAP) antibiotic residues in water. The approach is based on the use of decanoic acid as the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Royal Society
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86611/ http://psasir.upm.edu.my/id/eprint/86611/1/Magnetic%20nanoparticles%20.pdf |
| _version_ | 1848860244855226368 |
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| author | Md Saad, Salwani Aling, Nur Afiqah Miskam, Mazidatulakmam Saaid, Mardiana Mohamad Zain, Nur Nadhirah Kamaruzaman, Sazlinda Raoov, Muggundha Mohamad Hanapi, Nor Suhaila Wan Ibrahim, Wan Nazihah Yahaya, Noorfatimah |
| author_facet | Md Saad, Salwani Aling, Nur Afiqah Miskam, Mazidatulakmam Saaid, Mardiana Mohamad Zain, Nur Nadhirah Kamaruzaman, Sazlinda Raoov, Muggundha Mohamad Hanapi, Nor Suhaila Wan Ibrahim, Wan Nazihah Yahaya, Noorfatimah |
| author_sort | Md Saad, Salwani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This work describes the development of a new methodology based on magnetic nanoparticles assisted dispersive liquid–liquid microextraction (DLLME-MNPs) for preconcentration and extraction of chloramphenicol (CAP) antibiotic residues in water. The approach is based on the use of decanoic acid as the extraction solvent followed by the application of MNPs to magnetically retrieve the extraction solvent containing the extracted CAP. The coated MNPs were then desorbed with methanol, and the clean extract was analysed using ultraviolet–visible spectrophotometry. Several important parameters, such as the amount of decanoic acid, extraction time, stirring rate, amount of MNPs, type of desorption solvent, salt addition and sample pH, were evaluated and optimized. Optimum parameters were as follows: amount of decanoic acid: 200 mg; extraction time: 10 min; stirring rate: 800 rpm; amount of MNPs: 60 mg; desorption solvent: methanol; salt: 10%; and sample pH, 8. Under the optimum conditions, the method demonstrated acceptable linearity (R2 = 0.9933) over a concentration range of 50–1000 µg l–1. Limit of detection and limit of quantification were 16.5 and 50.0 µg l–1, respectively. Good analyte recovery (91–92.7%) and acceptable precision with good relative standard deviations (0.45–6.29%, n = 3) were obtained. The method was successfully applied to tap water and lake water samples. The proposed method is rapid, simple, reliable and environmentally friendly for the detection of CAP. |
| first_indexed | 2025-11-15T12:42:10Z |
| format | Article |
| id | upm-86611 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:42:10Z |
| publishDate | 2020 |
| publisher | Royal Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-866112021-10-11T10:35:53Z http://psasir.upm.edu.my/id/eprint/86611/ Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples Md Saad, Salwani Aling, Nur Afiqah Miskam, Mazidatulakmam Saaid, Mardiana Mohamad Zain, Nur Nadhirah Kamaruzaman, Sazlinda Raoov, Muggundha Mohamad Hanapi, Nor Suhaila Wan Ibrahim, Wan Nazihah Yahaya, Noorfatimah This work describes the development of a new methodology based on magnetic nanoparticles assisted dispersive liquid–liquid microextraction (DLLME-MNPs) for preconcentration and extraction of chloramphenicol (CAP) antibiotic residues in water. The approach is based on the use of decanoic acid as the extraction solvent followed by the application of MNPs to magnetically retrieve the extraction solvent containing the extracted CAP. The coated MNPs were then desorbed with methanol, and the clean extract was analysed using ultraviolet–visible spectrophotometry. Several important parameters, such as the amount of decanoic acid, extraction time, stirring rate, amount of MNPs, type of desorption solvent, salt addition and sample pH, were evaluated and optimized. Optimum parameters were as follows: amount of decanoic acid: 200 mg; extraction time: 10 min; stirring rate: 800 rpm; amount of MNPs: 60 mg; desorption solvent: methanol; salt: 10%; and sample pH, 8. Under the optimum conditions, the method demonstrated acceptable linearity (R2 = 0.9933) over a concentration range of 50–1000 µg l–1. Limit of detection and limit of quantification were 16.5 and 50.0 µg l–1, respectively. Good analyte recovery (91–92.7%) and acceptable precision with good relative standard deviations (0.45–6.29%, n = 3) were obtained. The method was successfully applied to tap water and lake water samples. The proposed method is rapid, simple, reliable and environmentally friendly for the detection of CAP. Royal Society 2020-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86611/1/Magnetic%20nanoparticles%20.pdf Md Saad, Salwani and Aling, Nur Afiqah and Miskam, Mazidatulakmam and Saaid, Mardiana and Mohamad Zain, Nur Nadhirah and Kamaruzaman, Sazlinda and Raoov, Muggundha and Mohamad Hanapi, Nor Suhaila and Wan Ibrahim, Wan Nazihah and Yahaya, Noorfatimah (2020) Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples. Royal Society Open Science, 7 (4). pp. 1-11. ISSN 2054-5703 https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200143 10.1098/rsos.200143 |
| spellingShingle | Md Saad, Salwani Aling, Nur Afiqah Miskam, Mazidatulakmam Saaid, Mardiana Mohamad Zain, Nur Nadhirah Kamaruzaman, Sazlinda Raoov, Muggundha Mohamad Hanapi, Nor Suhaila Wan Ibrahim, Wan Nazihah Yahaya, Noorfatimah Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| title | Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| title_full | Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| title_fullStr | Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| title_full_unstemmed | Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| title_short | Magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| title_sort | magnetic nanoparticles assisted dispersive liquid– liquid microextraction of chloramphenicol in water samples |
| url | http://psasir.upm.edu.my/id/eprint/86611/ http://psasir.upm.edu.my/id/eprint/86611/ http://psasir.upm.edu.my/id/eprint/86611/ http://psasir.upm.edu.my/id/eprint/86611/1/Magnetic%20nanoparticles%20.pdf |