Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects
Introduction: A growing evidence supported that variation of sweet taste perception, mediated by TAS1Rs gene variants could lead to excess sweetened food and beverages intake and also obesity. However, obesity development may also alter individuals' taste sensitivity and perception. Thus, it is...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/85445/ http://psasir.upm.edu.my/id/eprint/85445/1/1%20upm.pdf |
| _version_ | 1848860088179097600 |
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| author | Bahauddin, Ahmad Riduan Saari, Nazamid Mohd Shariff, Zalilah Karim, Roselina |
| author_facet | Bahauddin, Ahmad Riduan Saari, Nazamid Mohd Shariff, Zalilah Karim, Roselina |
| author_sort | Bahauddin, Ahmad Riduan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: A growing evidence supported that variation of sweet taste perception, mediated by TAS1Rs gene variants could lead to excess sweetened food and beverages intake and also obesity. However, obesity development may also alter individuals' taste sensitivity and perception. Thus, it is best to further investigate whether or not the individuals' sweet taste sensitivity and acceptance are associated with variation in TAS1R2 gene and Body Mass Index (BMI) status. Methods: This comparison cross sectional study comprised of 88 obese and 92 non-obese subjects aged 20-45. All the subjects were genotyped for TAS1R2 gene variant at rs12033832 using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP). Suprathreshold sensitivity for sweet taste was assessed using general Labeled Magnitude Scales. Intensity rating and hedonic test were carried out on 2 food samples (tea drink and rose flavoured agar) to examine subject's intensity rating and liking at different sugar contents. Results: Our results showed that rs12033832 of TAS1R2 gene is associated with sweet taste perception among obese and non-obese subjects. No interaction effect between BMI status and TAS1R2 gene variant (rs12022832) was found on sweet taste measures. Overall, non-obese subjects with AA genotype on rs12033832 had the highest sweet taste sensitivity and dislike high sugar content products the most. The effect was reverse among the obese subjects with GG homozygous. Conclusion: These findings suggest that TAS1R2 gene variation plays an important role in sweet taste perception among individuals and may have nutritional implications and obesity. |
| first_indexed | 2025-11-15T12:39:40Z |
| format | Article |
| id | upm-85445 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:39:40Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-854452021-08-04T12:37:20Z http://psasir.upm.edu.my/id/eprint/85445/ Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects Bahauddin, Ahmad Riduan Saari, Nazamid Mohd Shariff, Zalilah Karim, Roselina Introduction: A growing evidence supported that variation of sweet taste perception, mediated by TAS1Rs gene variants could lead to excess sweetened food and beverages intake and also obesity. However, obesity development may also alter individuals' taste sensitivity and perception. Thus, it is best to further investigate whether or not the individuals' sweet taste sensitivity and acceptance are associated with variation in TAS1R2 gene and Body Mass Index (BMI) status. Methods: This comparison cross sectional study comprised of 88 obese and 92 non-obese subjects aged 20-45. All the subjects were genotyped for TAS1R2 gene variant at rs12033832 using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP). Suprathreshold sensitivity for sweet taste was assessed using general Labeled Magnitude Scales. Intensity rating and hedonic test were carried out on 2 food samples (tea drink and rose flavoured agar) to examine subject's intensity rating and liking at different sugar contents. Results: Our results showed that rs12033832 of TAS1R2 gene is associated with sweet taste perception among obese and non-obese subjects. No interaction effect between BMI status and TAS1R2 gene variant (rs12022832) was found on sweet taste measures. Overall, non-obese subjects with AA genotype on rs12033832 had the highest sweet taste sensitivity and dislike high sugar content products the most. The effect was reverse among the obese subjects with GG homozygous. Conclusion: These findings suggest that TAS1R2 gene variation plays an important role in sweet taste perception among individuals and may have nutritional implications and obesity. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/85445/1/1%20upm.pdf Bahauddin, Ahmad Riduan and Saari, Nazamid and Mohd Shariff, Zalilah and Karim, Roselina (2020) Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects. Malaysian Journal of Medicine and Health Sciences, 16 (4). pp. 4-12. ISSN 1675-8544; ESSN:2636-9346 https://medic.upm.edu.my/jurnal_kami/malaysian_journal_of_medicine_and_health_sciences_mjmhs/mjmhs_vol_16_no_4_december_2020-59593 |
| spellingShingle | Bahauddin, Ahmad Riduan Saari, Nazamid Mohd Shariff, Zalilah Karim, Roselina Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects |
| title | Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects |
| title_full | Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects |
| title_fullStr | Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects |
| title_full_unstemmed | Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects |
| title_short | Association between TAS1R2 gene polymorphism (rs12033832) and sweet taste perception amongst Malay obese and non-obese subjects |
| title_sort | association between tas1r2 gene polymorphism (rs12033832) and sweet taste perception amongst malay obese and non-obese subjects |
| url | http://psasir.upm.edu.my/id/eprint/85445/ http://psasir.upm.edu.my/id/eprint/85445/ http://psasir.upm.edu.my/id/eprint/85445/1/1%20upm.pdf |