Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1H-MRS) for incomplete spinal cord injury patients: preliminary study
Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/85369/ http://psasir.upm.edu.my/id/eprint/85369/1/85369.pdf |
| _version_ | 1848860067040854016 |
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| author | Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal |
| author_facet | Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal |
| author_sort | Rusli, Nur Syahfinaz Hidayah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise
among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D
patients using proton magnetic resonance spectroscopy or 1
H-MRS. Methods: These metabolites were measured
from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed
the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1
H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x
35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1
H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1
H-MRS imaging could be used as a
potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of
FES cycling exercise. |
| first_indexed | 2025-11-15T12:39:20Z |
| format | Article |
| id | upm-85369 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:39:20Z |
| publishDate | 2021 |
| publisher | Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-853692025-05-30T01:48:32Z http://psasir.upm.edu.my/id/eprint/85369/ Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1H-MRS) for incomplete spinal cord injury patients: preliminary study Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal Introduction: This preliminary study aimed to non-invasively evaluate choline (CHO), creatine (Cr) and intramyocellular lipid (IMCL) metabolites in skeletal muscles at pre- and post-functional electrical stimulation (FES) exercise among incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale (ASIA-AIS) D patients using proton magnetic resonance spectroscopy or 1 H-MRS. Methods: These metabolites were measured from the vastus lateralis and semitendinosus muscles of three incomplete SCI ASIA-AIS D patients who completed the FES exercise and later underwent 3 Tesla (T) MRI (repetition time/echo time; TR/TE of 3500ms/100ms, field-ofview; FOV of 20cm, slice thickness of 6mm) and 1 H-MRS (TR/TE of 2000ms/31ms, voxel size of 20mm x 20mm x 35mm). Results: Out of those selected metabolites, only CHO value of vastus lateralis showed a statistically significant difference between pre- and post FES exercise 1 H-MRS scanning (p = 0.01). Conclusion: Therefore, this preliminary finding has postulated that the quantification of muscle metabolites using 1 H-MRS imaging could be used as a potential indicator in evaluating the muscle strength for incomplete SCI ASIA-AIS D patients after the completion of FES cycling exercise. Universiti Putra Malaysia 2021-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/85369/1/85369.pdf Rusli, Nur Syahfinaz Hidayah and Zakaria, Faikah and Abdul Razak, Hairil Rashmizal (2021) Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1H-MRS) for incomplete spinal cord injury patients: preliminary study. Malaysian Journal of Medicine and Health Sciences, 17 (2). pp. 4-10. ISSN 1675-8544; eISSN:2636-9346 https://medic.upm.edu.my/upload/dokumen/2021040610445401_MJMHS_0348.pdf |
| spellingShingle | Rusli, Nur Syahfinaz Hidayah Zakaria, Faikah Abdul Razak, Hairil Rashmizal Quantification of muscle metabolites using proton magnetic resonance spectroscopy (1H-MRS) for incomplete spinal cord injury patients: preliminary study |
| title | Quantification of muscle metabolites using proton magnetic
resonance spectroscopy (1H-MRS) for incomplete spinal cord
injury patients: preliminary study |
| title_full | Quantification of muscle metabolites using proton magnetic
resonance spectroscopy (1H-MRS) for incomplete spinal cord
injury patients: preliminary study |
| title_fullStr | Quantification of muscle metabolites using proton magnetic
resonance spectroscopy (1H-MRS) for incomplete spinal cord
injury patients: preliminary study |
| title_full_unstemmed | Quantification of muscle metabolites using proton magnetic
resonance spectroscopy (1H-MRS) for incomplete spinal cord
injury patients: preliminary study |
| title_short | Quantification of muscle metabolites using proton magnetic
resonance spectroscopy (1H-MRS) for incomplete spinal cord
injury patients: preliminary study |
| title_sort | quantification of muscle metabolites using proton magnetic
resonance spectroscopy (1h-mrs) for incomplete spinal cord
injury patients: preliminary study |
| url | http://psasir.upm.edu.my/id/eprint/85369/ http://psasir.upm.edu.my/id/eprint/85369/ http://psasir.upm.edu.my/id/eprint/85369/1/85369.pdf |