V protein, the virulence factor across the family Paramyxoviridae: a review
Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubu...
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| Format: | Article |
| Language: | English |
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Malaysian Society for Molecular Biology and Biotechnology
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82701/ http://psasir.upm.edu.my/id/eprint/82701/1/V%20protein%2C%20the%20virulence%20factor%20across%20the%20family%20Paramyxoviridae%20a%20review.pdf |
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| author | May, Ling Tham Yusoff, Khatijah Othman, Siti Sarah Suet, Lin Chia |
| author_facet | May, Ling Tham Yusoff, Khatijah Othman, Siti Sarah Suet, Lin Chia |
| author_sort | May, Ling Tham |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubulavirus. The members within this family are negative and single-stranded RNA viruses including human and animal pathogens such as measles virus (MeV), Nipah virus (NiV), mumps virus (MuV), Sendai virus (SeV) and Newcastle disease virus (NDV). The V protein is conserved within the family and plays an essential role in viral pathogenicity. Although V proteins of many paramyxoviruses are interferon-antagonists which counteract with the host’s innate immunity, there are still differences in the mode of action of the V protein between different genera or species within the same genera. The strategies to circumvent the host interferon (IFN) pathway can be divided into three general mechanisms; degradation of signal transducers and activators of transcription (STAT) protein, inhibition of phosphorylation of the transcription factor and, inhibition of translocation of STAT proteins into the nucleus. As a result, inhibition of IFN signalling and production promotes viral replication in the host cells. This review highlights the mechanism of the paramyxoviral V protein in evading the host IFN system. |
| first_indexed | 2025-11-15T12:27:39Z |
| format | Article |
| id | upm-82701 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:27:39Z |
| publishDate | 2019 |
| publisher | Malaysian Society for Molecular Biology and Biotechnology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-827012020-09-14T08:17:26Z http://psasir.upm.edu.my/id/eprint/82701/ V protein, the virulence factor across the family Paramyxoviridae: a review May, Ling Tham Yusoff, Khatijah Othman, Siti Sarah Suet, Lin Chia Paramyxoviridae is a family of viruses within the order Mononegavirales and comprises 14 genera; Metaavulavirus, Orthoavulavirus, Paraavulavirus, Synodonvirus, Ferlavirus, Aquaparamyxovirus, Henipavirus, Morbillivirus, Respirovirus, Jeilongvirus, Narmovirus, Salemvirus, Pararubulavirus and Orthorubulavirus. The members within this family are negative and single-stranded RNA viruses including human and animal pathogens such as measles virus (MeV), Nipah virus (NiV), mumps virus (MuV), Sendai virus (SeV) and Newcastle disease virus (NDV). The V protein is conserved within the family and plays an essential role in viral pathogenicity. Although V proteins of many paramyxoviruses are interferon-antagonists which counteract with the host’s innate immunity, there are still differences in the mode of action of the V protein between different genera or species within the same genera. The strategies to circumvent the host interferon (IFN) pathway can be divided into three general mechanisms; degradation of signal transducers and activators of transcription (STAT) protein, inhibition of phosphorylation of the transcription factor and, inhibition of translocation of STAT proteins into the nucleus. As a result, inhibition of IFN signalling and production promotes viral replication in the host cells. This review highlights the mechanism of the paramyxoviral V protein in evading the host IFN system. Malaysian Society for Molecular Biology and Biotechnology 2019-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82701/1/V%20protein%2C%20the%20virulence%20factor%20across%20the%20family%20Paramyxoviridae%20a%20review.pdf May, Ling Tham and Yusoff, Khatijah and Othman, Siti Sarah and Suet, Lin Chia (2019) V protein, the virulence factor across the family Paramyxoviridae: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (3). pp. 73-85. ISSN 0128-7451; ESSN: 2672-7277 10.35118/apjmbb.2019.027.3.08 |
| spellingShingle | May, Ling Tham Yusoff, Khatijah Othman, Siti Sarah Suet, Lin Chia V protein, the virulence factor across the family Paramyxoviridae: a review |
| title | V protein, the virulence factor across the family Paramyxoviridae: a review |
| title_full | V protein, the virulence factor across the family Paramyxoviridae: a review |
| title_fullStr | V protein, the virulence factor across the family Paramyxoviridae: a review |
| title_full_unstemmed | V protein, the virulence factor across the family Paramyxoviridae: a review |
| title_short | V protein, the virulence factor across the family Paramyxoviridae: a review |
| title_sort | v protein, the virulence factor across the family paramyxoviridae: a review |
| url | http://psasir.upm.edu.my/id/eprint/82701/ http://psasir.upm.edu.my/id/eprint/82701/ http://psasir.upm.edu.my/id/eprint/82701/1/V%20protein%2C%20the%20virulence%20factor%20across%20the%20family%20Paramyxoviridae%20a%20review.pdf |