Thyroid storm: is there a role for thyroid function test?
Introduction: Thyroid storm (TS) is an endocrine emergency. Early diagnosis for prompt treatment is essential as it has a high mortality rate. Case report: A 31-year-old lady with underlying hyperthyroidism, dilated cardiomyopathy with severe mitral regurgitation presented with shortness of breath....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Society of Pathologists
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82639/ http://psasir.upm.edu.my/id/eprint/82639/1/Thyroid%20storm%20is%20there%20a%20role%20for%20thyroid%20function%20test.pdf |
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| author | Tengku Ibrahim, T. Z. Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Nasuruddin, A. N. Zakaria, M. H. |
| author_facet | Tengku Ibrahim, T. Z. Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Nasuruddin, A. N. Zakaria, M. H. |
| author_sort | Tengku Ibrahim, T. Z. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Thyroid storm (TS) is an endocrine emergency. Early diagnosis for prompt treatment is essential as it has a high mortality rate. Case report: A 31-year-old lady with underlying hyperthyroidism, dilated cardiomyopathy with severe mitral regurgitation presented with shortness of breath. She was intubated and admitted due to decreasing Glasgow Coma Score. Her blood investigations revealed increased white cell count, raised free thyroxine with suppressed thyroid stimulating hormone, deranged liver, renal and coagulation profiles. As her condition did not improve with initial treatment, plasmapheresis was commenced on day 4. Biochemically, her thyroid function test (TFT) showed improvement; however, she succumbed due to multi-organ failure. Discussion: Plasmapheresis is considered in TS if there is no clinical improvement within 24-48 hours of initial treatment. The improvement in patient's TFT post plasmapheresis signifies its role in treating TS. Unfortunately, there was a delay in commencing plasmapheresis due to haemodynamic instability in this patient. |
| first_indexed | 2025-11-15T12:27:26Z |
| format | Article |
| id | upm-82639 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:27:26Z |
| publishDate | 2019 |
| publisher | Malaysian Society of Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-826392020-09-14T08:04:16Z http://psasir.upm.edu.my/id/eprint/82639/ Thyroid storm: is there a role for thyroid function test? Tengku Ibrahim, T. Z. Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Nasuruddin, A. N. Zakaria, M. H. Introduction: Thyroid storm (TS) is an endocrine emergency. Early diagnosis for prompt treatment is essential as it has a high mortality rate. Case report: A 31-year-old lady with underlying hyperthyroidism, dilated cardiomyopathy with severe mitral regurgitation presented with shortness of breath. She was intubated and admitted due to decreasing Glasgow Coma Score. Her blood investigations revealed increased white cell count, raised free thyroxine with suppressed thyroid stimulating hormone, deranged liver, renal and coagulation profiles. As her condition did not improve with initial treatment, plasmapheresis was commenced on day 4. Biochemically, her thyroid function test (TFT) showed improvement; however, she succumbed due to multi-organ failure. Discussion: Plasmapheresis is considered in TS if there is no clinical improvement within 24-48 hours of initial treatment. The improvement in patient's TFT post plasmapheresis signifies its role in treating TS. Unfortunately, there was a delay in commencing plasmapheresis due to haemodynamic instability in this patient. Malaysian Society of Pathologists 2019-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82639/1/Thyroid%20storm%20is%20there%20a%20role%20for%20thyroid%20function%20test.pdf Tengku Ibrahim, T. Z. and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna and Nasuruddin, A. N. and Zakaria, M. H. (2019) Thyroid storm: is there a role for thyroid function test? Malaysian Journal of Pathology, 41 (3). pp. 355-358. ISSN 0126-8635 |
| spellingShingle | Tengku Ibrahim, T. Z. Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Nasuruddin, A. N. Zakaria, M. H. Thyroid storm: is there a role for thyroid function test? |
| title | Thyroid storm: is there a role for thyroid function test? |
| title_full | Thyroid storm: is there a role for thyroid function test? |
| title_fullStr | Thyroid storm: is there a role for thyroid function test? |
| title_full_unstemmed | Thyroid storm: is there a role for thyroid function test? |
| title_short | Thyroid storm: is there a role for thyroid function test? |
| title_sort | thyroid storm: is there a role for thyroid function test? |
| url | http://psasir.upm.edu.my/id/eprint/82639/ http://psasir.upm.edu.my/id/eprint/82639/1/Thyroid%20storm%20is%20there%20a%20role%20for%20thyroid%20function%20test.pdf |