TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies
Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a cont...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82443/ http://psasir.upm.edu.my/id/eprint/82443/1/TRPM2%20channel%20in%20microglia%20as%20a%20new%20player%20in%20neuroinflammation%20associated%20with%20a%20spectrum%20of%20central%20nervous%20system%20pathologies.pdf |
| _version_ | 1848859289854148608 |
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| author | Malko, Philippa Syed Mortadza, Sharifah Alawieyah McWilliam, Joseph Jiang, Lin Hua |
| author_facet | Malko, Philippa Syed Mortadza, Sharifah Alawieyah McWilliam, Joseph Jiang, Lin Hua |
| author_sort | Malko, Philippa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a contributing factor in a wide spectrum of CNS pathologies, including ischemic stroke, traumatic brain damage, Alzheimer's disease, Parkinson's disease, multiple sclerosis, psychiatric disorders, autism spectrum disorders, and chronic neuropathic pain. Oxidative stress is a salient and common feature of these conditions and has been strongly implicated in microglial cell activation and neuroinflammation. The transient receptor potential melastatin-related 2 (TRPM2) channel, an oxidative stress-sensitive calcium-permeable cationic channel, is highly expressed in microglial cells. In this review, we examine the recent studies that provide evidence to support an important role for the TRPM2 channel, particularly TRPM2-mediated Ca²ᶧ signaling, in mediating microglial cell activation, generation of proinflammatory mediators and neuroinflammation, which are of relevance to CNS pathologies. These findings lead to a growing interest in the TRPM2 channel, a new player in neuroinflammation, as a novel therapeutic target for CNS diseases. |
| first_indexed | 2025-11-15T12:26:59Z |
| format | Article |
| id | upm-82443 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:26:59Z |
| publishDate | 2019 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-824432021-08-12T01:29:29Z http://psasir.upm.edu.my/id/eprint/82443/ TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies Malko, Philippa Syed Mortadza, Sharifah Alawieyah McWilliam, Joseph Jiang, Lin Hua Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a contributing factor in a wide spectrum of CNS pathologies, including ischemic stroke, traumatic brain damage, Alzheimer's disease, Parkinson's disease, multiple sclerosis, psychiatric disorders, autism spectrum disorders, and chronic neuropathic pain. Oxidative stress is a salient and common feature of these conditions and has been strongly implicated in microglial cell activation and neuroinflammation. The transient receptor potential melastatin-related 2 (TRPM2) channel, an oxidative stress-sensitive calcium-permeable cationic channel, is highly expressed in microglial cells. In this review, we examine the recent studies that provide evidence to support an important role for the TRPM2 channel, particularly TRPM2-mediated Ca²ᶧ signaling, in mediating microglial cell activation, generation of proinflammatory mediators and neuroinflammation, which are of relevance to CNS pathologies. These findings lead to a growing interest in the TRPM2 channel, a new player in neuroinflammation, as a novel therapeutic target for CNS diseases. Frontiers Media 2019-03 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82443/1/TRPM2%20channel%20in%20microglia%20as%20a%20new%20player%20in%20neuroinflammation%20associated%20with%20a%20spectrum%20of%20central%20nervous%20system%20pathologies.pdf Malko, Philippa and Syed Mortadza, Sharifah Alawieyah and McWilliam, Joseph and Jiang, Lin Hua (2019) TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies. Frontiers in Pharmacology, 10. art. no. 239. pp. 1-13. ISSN 1663-9812 https://www.frontiersin.org/articles/10.3389/fphar.2019.00239/full 10.3389/fphar.2019.00239 |
| spellingShingle | Malko, Philippa Syed Mortadza, Sharifah Alawieyah McWilliam, Joseph Jiang, Lin Hua TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| title | TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| title_full | TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| title_fullStr | TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| title_full_unstemmed | TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| title_short | TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| title_sort | trpm2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies |
| url | http://psasir.upm.edu.my/id/eprint/82443/ http://psasir.upm.edu.my/id/eprint/82443/ http://psasir.upm.edu.my/id/eprint/82443/ http://psasir.upm.edu.my/id/eprint/82443/1/TRPM2%20channel%20in%20microglia%20as%20a%20new%20player%20in%20neuroinflammation%20associated%20with%20a%20spectrum%20of%20central%20nervous%20system%20pathologies.pdf |