Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study
Neopterin (NEO) is a useful biomarker for detection of malignant diseases. However, adsorption study using graphene oxide-molecularly imprinted polymer (GO-MIP) material has been lacking. The aim of this research was to synthesize and characterize GO-MIP for use in NEO adsorption study. GO-MIP with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82336/ http://psasir.upm.edu.my/id/eprint/82336/1/Synthesis%20and%20characterization%20of%20graphene%20oxide-molecularly%20imprinted%20polymer%20for%20Neopterin%20adsorption%20study.pdf |
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| author | Khoo, Wai Chat Kamaruzaman, Sazlinda Lim, Hong Ngee Md Jamil, Siti Nurul Ain Yahaya, Noorfatimah |
| author_facet | Khoo, Wai Chat Kamaruzaman, Sazlinda Lim, Hong Ngee Md Jamil, Siti Nurul Ain Yahaya, Noorfatimah |
| author_sort | Khoo, Wai Chat |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Neopterin (NEO) is a useful biomarker for detection of malignant diseases. However, adsorption study using graphene oxide-molecularly imprinted polymer (GO-MIP) material has been lacking. The aim of this research was to synthesize and characterize GO-MIP for use in NEO adsorption study. GO-MIP with NEO as the template was synthesized via free radical polymerization method, with methacrylic acid (MAA) as the monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, ammonium persulfate (APS) as the initiator, and 8/2 v/v ratio of dimethylsulfoxide/acetonitrile (DMSO/ACN) solution as porogen solvent. The formation of GO-MIP hybrid with NEO binding sites was verified via Fourier transform infrared spectroscopy (FTIR), CHNS analysis, thermogravimetric analysis (TGA), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). GO-MIP adsorbed twice the amount of NEO compared to its non-imprinted counterpart, and showed good NEO selectivity when under the effect of analog compound 6-biopterin (BIO). The adsorption mechanism and kinetics were best described using Freundlich isotherm and Lagergren pseudo-second-order, respectively. The adsorption capacity at equilibrium was found to be 0.4749 mg/g with the adsorption parameters as described (10 mg GO-MIP, 1 mL NEO 10 ppm). |
| first_indexed | 2025-11-15T12:26:46Z |
| format | Article |
| id | upm-82336 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:26:46Z |
| publishDate | 2019 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-823362021-08-09T02:44:51Z http://psasir.upm.edu.my/id/eprint/82336/ Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study Khoo, Wai Chat Kamaruzaman, Sazlinda Lim, Hong Ngee Md Jamil, Siti Nurul Ain Yahaya, Noorfatimah Neopterin (NEO) is a useful biomarker for detection of malignant diseases. However, adsorption study using graphene oxide-molecularly imprinted polymer (GO-MIP) material has been lacking. The aim of this research was to synthesize and characterize GO-MIP for use in NEO adsorption study. GO-MIP with NEO as the template was synthesized via free radical polymerization method, with methacrylic acid (MAA) as the monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, ammonium persulfate (APS) as the initiator, and 8/2 v/v ratio of dimethylsulfoxide/acetonitrile (DMSO/ACN) solution as porogen solvent. The formation of GO-MIP hybrid with NEO binding sites was verified via Fourier transform infrared spectroscopy (FTIR), CHNS analysis, thermogravimetric analysis (TGA), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). GO-MIP adsorbed twice the amount of NEO compared to its non-imprinted counterpart, and showed good NEO selectivity when under the effect of analog compound 6-biopterin (BIO). The adsorption mechanism and kinetics were best described using Freundlich isotherm and Lagergren pseudo-second-order, respectively. The adsorption capacity at equilibrium was found to be 0.4749 mg/g with the adsorption parameters as described (10 mg GO-MIP, 1 mL NEO 10 ppm). Springer 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82336/1/Synthesis%20and%20characterization%20of%20graphene%20oxide-molecularly%20imprinted%20polymer%20for%20Neopterin%20adsorption%20study.pdf Khoo, Wai Chat and Kamaruzaman, Sazlinda and Lim, Hong Ngee and Md Jamil, Siti Nurul Ain and Yahaya, Noorfatimah (2019) Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study. Journal of Polymer Research, 26 (8). pp. 1-10. ISSN 1022-9760; ESSN: 1572-8935 https://www.infona.pl/resource/bwmeta1.element.springer-doi-10_1007-S10965-019-1847-9 10.1007/s10965-019-1847-9 |
| spellingShingle | Khoo, Wai Chat Kamaruzaman, Sazlinda Lim, Hong Ngee Md Jamil, Siti Nurul Ain Yahaya, Noorfatimah Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study |
| title | Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study |
| title_full | Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study |
| title_fullStr | Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study |
| title_full_unstemmed | Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study |
| title_short | Synthesis and characterization of graphene oxide-molecularly imprinted polymer for Neopterin adsorption study |
| title_sort | synthesis and characterization of graphene oxide-molecularly imprinted polymer for neopterin adsorption study |
| url | http://psasir.upm.edu.my/id/eprint/82336/ http://psasir.upm.edu.my/id/eprint/82336/ http://psasir.upm.edu.my/id/eprint/82336/ http://psasir.upm.edu.my/id/eprint/82336/1/Synthesis%20and%20characterization%20of%20graphene%20oxide-molecularly%20imprinted%20polymer%20for%20Neopterin%20adsorption%20study.pdf |