Some chemical carcinogens for leukaemia induction and their animal models
Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciencedomain International
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/82211/ http://psasir.upm.edu.my/id/eprint/82211/1/Some%20chemical%20carcinogens%20for%20leukaemia%20induction%20and%20their%20animal%20models.pdf |
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| author | Aliyu, Abdullahi Shaari, Mohd Rosly Mustapha, Noordin Mohamed Ahmad Sayuti, Nurul Syahirah Reduan, Mohd Farhan Hanif Sithambaram, Shanmugavelu Shaari, Khozirah Hamzah, Hazilawati |
| author_facet | Aliyu, Abdullahi Shaari, Mohd Rosly Mustapha, Noordin Mohamed Ahmad Sayuti, Nurul Syahirah Reduan, Mohd Farhan Hanif Sithambaram, Shanmugavelu Shaari, Khozirah Hamzah, Hazilawati |
| author_sort | Aliyu, Abdullahi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal models, including rats and mice. The studies in most cases are aimed at the development and evaluation of cancer treatments and preventions. Some of the most common chemical carcinogens used in animal models for leukaemias include N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU), dimethyl benz(a)anthracene (DMBA) and benzo(a)pyrene (BaP). This review provides highlights on different animal models of leukaemia induced by the chemical carcinogens mentioned earlier, at the same time discussing the contributions of these models to the leukaemia diagnosis in laboratory animal models for subsequent development of treatment. |
| first_indexed | 2025-11-15T12:26:30Z |
| format | Article |
| id | upm-82211 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:26:30Z |
| publishDate | 2019 |
| publisher | Sciencedomain International |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-822112020-12-16T14:29:38Z http://psasir.upm.edu.my/id/eprint/82211/ Some chemical carcinogens for leukaemia induction and their animal models Aliyu, Abdullahi Shaari, Mohd Rosly Mustapha, Noordin Mohamed Ahmad Sayuti, Nurul Syahirah Reduan, Mohd Farhan Hanif Sithambaram, Shanmugavelu Shaari, Khozirah Hamzah, Hazilawati Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal models, including rats and mice. The studies in most cases are aimed at the development and evaluation of cancer treatments and preventions. Some of the most common chemical carcinogens used in animal models for leukaemias include N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU), dimethyl benz(a)anthracene (DMBA) and benzo(a)pyrene (BaP). This review provides highlights on different animal models of leukaemia induced by the chemical carcinogens mentioned earlier, at the same time discussing the contributions of these models to the leukaemia diagnosis in laboratory animal models for subsequent development of treatment. Sciencedomain International 2019-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/82211/1/Some%20chemical%20carcinogens%20for%20leukaemia%20induction%20and%20their%20animal%20models.pdf Aliyu, Abdullahi and Shaari, Mohd Rosly and Mustapha, Noordin Mohamed and Ahmad Sayuti, Nurul Syahirah and Reduan, Mohd Farhan Hanif and Sithambaram, Shanmugavelu and Shaari, Khozirah and Hamzah, Hazilawati (2019) Some chemical carcinogens for leukaemia induction and their animal models. Annual Research & Review in Biology, 33 (1). art. no. ARRB.50887. pp. 1-7. ISSN 2347-565X 10.9734/ARRB/2019/v33i130108 |
| spellingShingle | Aliyu, Abdullahi Shaari, Mohd Rosly Mustapha, Noordin Mohamed Ahmad Sayuti, Nurul Syahirah Reduan, Mohd Farhan Hanif Sithambaram, Shanmugavelu Shaari, Khozirah Hamzah, Hazilawati Some chemical carcinogens for leukaemia induction and their animal models |
| title | Some chemical carcinogens for leukaemia induction and their animal models |
| title_full | Some chemical carcinogens for leukaemia induction and their animal models |
| title_fullStr | Some chemical carcinogens for leukaemia induction and their animal models |
| title_full_unstemmed | Some chemical carcinogens for leukaemia induction and their animal models |
| title_short | Some chemical carcinogens for leukaemia induction and their animal models |
| title_sort | some chemical carcinogens for leukaemia induction and their animal models |
| url | http://psasir.upm.edu.my/id/eprint/82211/ http://psasir.upm.edu.my/id/eprint/82211/ http://psasir.upm.edu.my/id/eprint/82211/1/Some%20chemical%20carcinogens%20for%20leukaemia%20induction%20and%20their%20animal%20models.pdf |