Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids
Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microb...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81938/ http://psasir.upm.edu.my/id/eprint/81938/1/Recent%20advancement%20of%20engineering%20microbial.pdf |
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| author | Azman Shah, Fatin Lyana Ramzi, Ahmad Bazli Baharum, Syarul Mohd Noor, Normah Goh, Hoe Han Leow, Thean Chor Oslan, Siti Nurbaya Sabri, Suriana |
| author_facet | Azman Shah, Fatin Lyana Ramzi, Ahmad Bazli Baharum, Syarul Mohd Noor, Normah Goh, Hoe Han Leow, Thean Chor Oslan, Siti Nurbaya Sabri, Suriana |
| author_sort | Azman Shah, Fatin Lyana |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds. |
| first_indexed | 2025-11-15T12:25:36Z |
| format | Article |
| id | upm-81938 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:25:36Z |
| publishDate | 2019 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-819382021-09-29T01:52:15Z http://psasir.upm.edu.my/id/eprint/81938/ Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids Azman Shah, Fatin Lyana Ramzi, Ahmad Bazli Baharum, Syarul Mohd Noor, Normah Goh, Hoe Han Leow, Thean Chor Oslan, Siti Nurbaya Sabri, Suriana Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds. Springer 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81938/1/Recent%20advancement%20of%20engineering%20microbial.pdf Azman Shah, Fatin Lyana and Ramzi, Ahmad Bazli and Baharum, Syarul and Mohd Noor, Normah and Goh, Hoe Han and Leow, Thean Chor and Oslan, Siti Nurbaya and Sabri, Suriana (2019) Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids. Molecular Biology Reports, 46 (11). pp. 6647-6659. ISSN 0301-4851; ESSN: 1573-4978 https://link.springer.com/article/10.1007%2Fs11033-019-05066-1 10.1007/s11033-019-05066-1 |
| spellingShingle | Azman Shah, Fatin Lyana Ramzi, Ahmad Bazli Baharum, Syarul Mohd Noor, Normah Goh, Hoe Han Leow, Thean Chor Oslan, Siti Nurbaya Sabri, Suriana Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| title | Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| title_full | Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| title_fullStr | Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| title_full_unstemmed | Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| title_short | Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| title_sort | recent advancement of engineering microbial hosts for the biotechnological production of flavonoids |
| url | http://psasir.upm.edu.my/id/eprint/81938/ http://psasir.upm.edu.my/id/eprint/81938/ http://psasir.upm.edu.my/id/eprint/81938/ http://psasir.upm.edu.my/id/eprint/81938/1/Recent%20advancement%20of%20engineering%20microbial.pdf |