Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting
The analytical method used in the quality control of Clinacanthus nutans leaves has not been well developed. Therefore, this study aimed to develop a simple analytical method to predict α-glucosidase inhibitory activity of this herb based on its infrared fingerprinting. The dried extracts obtained f...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81933/ http://psasir.upm.edu.my/id/eprint/81933/1/Rapid%20investigation%20of%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Clinacanthus%20nutans%20leaf%20using%20infrared%20fingerprinting.pdf |
| _version_ | 1848859201679392768 |
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| author | Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Saari, Khozirah Khatib, Alfi |
| author_facet | Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Saari, Khozirah Khatib, Alfi |
| author_sort | Murugesu, Suganya |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The analytical method used in the quality control of Clinacanthus nutans leaves has not been well developed. Therefore, this study aimed to develop a simple analytical method to predict α-glucosidase inhibitory activity of this herb based on its infrared fingerprinting. The dried extracts obtained from maceration using solvents with different polarities were evaluated for the α-glucosidase inhibitory activity and analysed through infrared spectroscopy. Multivariate data analysis was performed by correlating the bioactivity and infrared spectrum of each extract using partial least square method. The loading plot from multivariate data analysis revealed that C single bond H and Cdouble bond O infrared signals from terpenoids in the extract were positively correlated with the α-glucosidase inhibitory activity. The developed partial least square model was validated through a testing on the external samples. The result concludes that the developed model is valid and capable of predicting α-glucosidase inhibitory activity of the external samples. |
| first_indexed | 2025-11-15T12:25:35Z |
| format | Article |
| id | upm-81933 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:25:35Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-819332021-09-08T00:23:04Z http://psasir.upm.edu.my/id/eprint/81933/ Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Saari, Khozirah Khatib, Alfi The analytical method used in the quality control of Clinacanthus nutans leaves has not been well developed. Therefore, this study aimed to develop a simple analytical method to predict α-glucosidase inhibitory activity of this herb based on its infrared fingerprinting. The dried extracts obtained from maceration using solvents with different polarities were evaluated for the α-glucosidase inhibitory activity and analysed through infrared spectroscopy. Multivariate data analysis was performed by correlating the bioactivity and infrared spectrum of each extract using partial least square method. The loading plot from multivariate data analysis revealed that C single bond H and Cdouble bond O infrared signals from terpenoids in the extract were positively correlated with the α-glucosidase inhibitory activity. The developed partial least square model was validated through a testing on the external samples. The result concludes that the developed model is valid and capable of predicting α-glucosidase inhibitory activity of the external samples. Elsevier 2019-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81933/1/Rapid%20investigation%20of%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Clinacanthus%20nutans%20leaf%20using%20infrared%20fingerprinting.pdf Murugesu, Suganya and Ahmed, Qamar Uddin and Uzir, Bisha Fathamah and Nik Yusoff, Nik Idris and Perumal, Vikneswari and Ibrahim, Zalikha and Abas, Faridah and Saari, Khozirah and Khatib, Alfi (2019) Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting. Vibrational Spectroscopy, 100. pp. 22-29. ISSN 0924-2031, ESSN: 1873-3697 https://www.sciencedirect.com/science/article/abs/pii/S0924203118300626 10.1016/j.vibspec.2018.10.007 |
| spellingShingle | Murugesu, Suganya Ahmed, Qamar Uddin Uzir, Bisha Fathamah Nik Yusoff, Nik Idris Perumal, Vikneswari Ibrahim, Zalikha Abas, Faridah Saari, Khozirah Khatib, Alfi Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting |
| title | Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting |
| title_full | Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting |
| title_fullStr | Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting |
| title_full_unstemmed | Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting |
| title_short | Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting |
| title_sort | rapid investigation of α-glucosidase inhibitory activity of clinacanthus nutans leaf using infrared fingerprinting |
| url | http://psasir.upm.edu.my/id/eprint/81933/ http://psasir.upm.edu.my/id/eprint/81933/ http://psasir.upm.edu.my/id/eprint/81933/ http://psasir.upm.edu.my/id/eprint/81933/1/Rapid%20investigation%20of%20%CE%B1-glucosidase%20inhibitory%20activity%20of%20Clinacanthus%20nutans%20leaf%20using%20infrared%20fingerprinting.pdf |