PET-CT in esophageal cancer management: a cost effectiveness analysis study
The present investigation dealt with the assessment of clinicians perceived views on the impact of PET-CT in esophageal cancer management from practicality, clinical efficacy and cost –effectiveness point of views. Reviews on publication and retrospective data to develop and carry out a decision-ma...
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| Format: | Article |
| Language: | English |
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Universiti Teknologi Malaysia
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81688/ http://psasir.upm.edu.my/id/eprint/81688/1/PET-CT%20in%20esophageal%20cancer.pdf |
| _version_ | 1848859162778271744 |
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| author | Azmi, Nor Aniza Abdul Razak, Hairil Rashmizal Vinjamuri, Sobhan |
| author_facet | Azmi, Nor Aniza Abdul Razak, Hairil Rashmizal Vinjamuri, Sobhan |
| author_sort | Azmi, Nor Aniza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present investigation dealt with the assessment of clinicians perceived views on the impact of PET-CT in esophageal cancer management from practicality, clinical efficacy and cost –effectiveness point of views. Reviews on publication and retrospective data to develop and carry out a decision-making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in esophageal cancer management staging compared with conventional pathway. Clinicians identified from patient medical records were included in the survey. Retrospective analysis of patient data from 2001-2008 was taken from esophageal cancer patient medical records and North West Cancer Intelligence Services (NWCIS) database. A decision tree was developed using TREEAGE software. The results of the cost-effectiveness analysis were presented in terms of the incremental cost-effectiveness ratios (I-CERs). PET compared with conventional work-up results for ICER for the strategy estimated at £28,460 per QALY; PET/CT compared with PET for ICER was £ 32,590 per QALY; and the ICER for PET/CT combined with conventional work-up versus PET/CT was £ 44,118. The package became more expensive with each additional diagnostic test added to PET and more effective in terms of QALYs gained. The conventional work-up was the preferred options as probabilistic sensitivity analysis showed at a willingness-to-pay threshold of £ 20,000 per QALY. Result of the current analysis suggested that the use of PET/CT in the diagnosis of esophageal cancer was unlikely to be cost-effective given the current willingness-to-pay thresholds that were accepted in the United Kingdom by decision-making bodies such as the National Institute for Health and Clinical Excellence. |
| first_indexed | 2025-11-15T12:24:58Z |
| format | Article |
| id | upm-81688 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:24:58Z |
| publishDate | 2019 |
| publisher | Universiti Teknologi Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-816882022-12-19T07:43:56Z http://psasir.upm.edu.my/id/eprint/81688/ PET-CT in esophageal cancer management: a cost effectiveness analysis study Azmi, Nor Aniza Abdul Razak, Hairil Rashmizal Vinjamuri, Sobhan The present investigation dealt with the assessment of clinicians perceived views on the impact of PET-CT in esophageal cancer management from practicality, clinical efficacy and cost –effectiveness point of views. Reviews on publication and retrospective data to develop and carry out a decision-making model-based economic evaluation to investigate the relative cost-effectiveness of PET/CT in esophageal cancer management staging compared with conventional pathway. Clinicians identified from patient medical records were included in the survey. Retrospective analysis of patient data from 2001-2008 was taken from esophageal cancer patient medical records and North West Cancer Intelligence Services (NWCIS) database. A decision tree was developed using TREEAGE software. The results of the cost-effectiveness analysis were presented in terms of the incremental cost-effectiveness ratios (I-CERs). PET compared with conventional work-up results for ICER for the strategy estimated at £28,460 per QALY; PET/CT compared with PET for ICER was £ 32,590 per QALY; and the ICER for PET/CT combined with conventional work-up versus PET/CT was £ 44,118. The package became more expensive with each additional diagnostic test added to PET and more effective in terms of QALYs gained. The conventional work-up was the preferred options as probabilistic sensitivity analysis showed at a willingness-to-pay threshold of £ 20,000 per QALY. Result of the current analysis suggested that the use of PET/CT in the diagnosis of esophageal cancer was unlikely to be cost-effective given the current willingness-to-pay thresholds that were accepted in the United Kingdom by decision-making bodies such as the National Institute for Health and Clinical Excellence. Universiti Teknologi Malaysia 2019-02-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81688/1/PET-CT%20in%20esophageal%20cancer.pdf Azmi, Nor Aniza and Abdul Razak, Hairil Rashmizal and Vinjamuri, Sobhan (2019) PET-CT in esophageal cancer management: a cost effectiveness analysis study. Malaysian Journal of Fundamental and Applied Sciences, 15 (1). pp. 121-124. ISSN 2289-5981; ESSN: 2289-599X https://mjfas.utm.my/index.php/mjfas/article/view/1143 10.11113/mjfas.v15n1.1143 |
| spellingShingle | Azmi, Nor Aniza Abdul Razak, Hairil Rashmizal Vinjamuri, Sobhan PET-CT in esophageal cancer management: a cost effectiveness analysis study |
| title | PET-CT in esophageal cancer management: a cost effectiveness analysis study |
| title_full | PET-CT in esophageal cancer management: a cost effectiveness analysis study |
| title_fullStr | PET-CT in esophageal cancer management: a cost effectiveness analysis study |
| title_full_unstemmed | PET-CT in esophageal cancer management: a cost effectiveness analysis study |
| title_short | PET-CT in esophageal cancer management: a cost effectiveness analysis study |
| title_sort | pet-ct in esophageal cancer management: a cost effectiveness analysis study |
| url | http://psasir.upm.edu.my/id/eprint/81688/ http://psasir.upm.edu.my/id/eprint/81688/ http://psasir.upm.edu.my/id/eprint/81688/ http://psasir.upm.edu.my/id/eprint/81688/1/PET-CT%20in%20esophageal%20cancer.pdf |