Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats
Aflatoxin B₁(AFB₁) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. Howeve...
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| Format: | Article |
| Language: | English |
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Hogrefe Verlag GmbH and Co. KG
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81586/ http://psasir.upm.edu.my/id/eprint/81586/1/Oral%20administration%20of%20Lactobacillus%20casei%20Shirota%20can%20ameliorate%20the%20adverse%20effect%20of%20an%20acute%20aflatoxin%20exposure%20in%20sprague%20dawley%20rats.pdf |
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| author | Nikbakht, Elham Jamaluddin, Rosita Sabran, Mohd Redzwan Khalesi, Saman |
| author_facet | Nikbakht, Elham Jamaluddin, Rosita Sabran, Mohd Redzwan Khalesi, Saman |
| author_sort | Nikbakht, Elham |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Aflatoxin B₁(AFB₁) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB₁ in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB₁ only (n = 9); AFB₁ treated with LcS (n = 9); and control (no AFB₁ exposure) (n = 6) groups. The blood AFB₁ level of rats treated with LcS was slightly lower than the untreated AFB₁ induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g-1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB₁ induced rats. However, a trend for a significant difference was only observed in ALT of AFB₁ induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats' body weight decreased in all animals force-fed with AFB₁ with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB₁ in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings. |
| first_indexed | 2025-11-15T12:24:38Z |
| format | Article |
| id | upm-81586 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:24:38Z |
| publishDate | 2019 |
| publisher | Hogrefe Verlag GmbH and Co. KG |
| recordtype | eprints |
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| spelling | upm-815862020-11-02T19:34:48Z http://psasir.upm.edu.my/id/eprint/81586/ Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats Nikbakht, Elham Jamaluddin, Rosita Sabran, Mohd Redzwan Khalesi, Saman Aflatoxin B₁(AFB₁) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB₁ in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB₁ only (n = 9); AFB₁ treated with LcS (n = 9); and control (no AFB₁ exposure) (n = 6) groups. The blood AFB₁ level of rats treated with LcS was slightly lower than the untreated AFB₁ induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g-1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB₁ induced rats. However, a trend for a significant difference was only observed in ALT of AFB₁ induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats' body weight decreased in all animals force-fed with AFB₁ with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB₁ in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings. Hogrefe Verlag GmbH and Co. KG 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81586/1/Oral%20administration%20of%20Lactobacillus%20casei%20Shirota%20can%20ameliorate%20the%20adverse%20effect%20of%20an%20acute%20aflatoxin%20exposure%20in%20sprague%20dawley%20rats.pdf Nikbakht, Elham and Jamaluddin, Rosita and Sabran, Mohd Redzwan and Khalesi, Saman (2019) Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats. International Journal for Vitamin and Nutrition Research, 88 (3-4). pp. 199-208. ISSN 1664-2821; ESSN: 0300-9831 https://pubmed.ncbi.nlm.nih.gov/31056010/ 10.1024/0300-9831/a000513 |
| spellingShingle | Nikbakht, Elham Jamaluddin, Rosita Sabran, Mohd Redzwan Khalesi, Saman Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| title | Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| title_full | Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| title_fullStr | Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| title_full_unstemmed | Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| title_short | Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| title_sort | oral administration of lactobacillus casei shirota can ameliorate the adverse effect of an acute aflatoxin exposure in sprague dawley rats |
| url | http://psasir.upm.edu.my/id/eprint/81586/ http://psasir.upm.edu.my/id/eprint/81586/ http://psasir.upm.edu.my/id/eprint/81586/ http://psasir.upm.edu.my/id/eprint/81586/1/Oral%20administration%20of%20Lactobacillus%20casei%20Shirota%20can%20ameliorate%20the%20adverse%20effect%20of%20an%20acute%20aflatoxin%20exposure%20in%20sprague%20dawley%20rats.pdf |