Mechanism of apoptosis induced by curcumin in colorectal cancer
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute (MDPI)
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81324/ http://psasir.upm.edu.my/id/eprint/81324/1/Mechanism%20of%20apoptosis%20induced%20by%20curcumin%20in%20colorectal%20cancer.pdf |
| _version_ | 1848859077581471744 |
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| author | Ismail, Nor Isnida Othman, Iekhsan Abas, Faridah Lajis, Nordin H. Naidu, Rakesh |
| author_facet | Ismail, Nor Isnida Othman, Iekhsan Abas, Faridah Lajis, Nordin H. Naidu, Rakesh |
| author_sort | Ismail, Nor Isnida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, surgery and radiotherapy, which are usually accompanied with major side effects, are rarely cured along with poor survival rate and at higher recurrence outcome. This trigger the needs of exploring new natural compounds with anti-cancer properties which possess fewer side effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis by targeting various molecules and signaling pathways involved in CRC. Disruption of the homeostatic balance between cell proliferation and apoptosis could be one of the promoting factors in colorectal cancer progression. In this review, we describe the current knowledge of apoptosis regulation by curcumin in CRC with regard to molecular targets and associated signaling pathways. |
| first_indexed | 2025-11-15T12:23:36Z |
| format | Article |
| id | upm-81324 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:23:36Z |
| publishDate | 2019 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-813242021-02-23T18:33:17Z http://psasir.upm.edu.my/id/eprint/81324/ Mechanism of apoptosis induced by curcumin in colorectal cancer Ismail, Nor Isnida Othman, Iekhsan Abas, Faridah Lajis, Nordin H. Naidu, Rakesh Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, surgery and radiotherapy, which are usually accompanied with major side effects, are rarely cured along with poor survival rate and at higher recurrence outcome. This trigger the needs of exploring new natural compounds with anti-cancer properties which possess fewer side effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis by targeting various molecules and signaling pathways involved in CRC. Disruption of the homeostatic balance between cell proliferation and apoptosis could be one of the promoting factors in colorectal cancer progression. In this review, we describe the current knowledge of apoptosis regulation by curcumin in CRC with regard to molecular targets and associated signaling pathways. Multidisciplinary Digital Publishing Institute (MDPI) 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81324/1/Mechanism%20of%20apoptosis%20induced%20by%20curcumin%20in%20colorectal%20cancer.pdf Ismail, Nor Isnida and Othman, Iekhsan and Abas, Faridah and Lajis, Nordin H. and Naidu, Rakesh (2019) Mechanism of apoptosis induced by curcumin in colorectal cancer. International Journal of Molecular Sciences, 20. art. no. 2454. pp. 1-34. ISSN 1422-0067; ESSN: 1661-6596 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566943/ 10.3390/ijms20102454 |
| spellingShingle | Ismail, Nor Isnida Othman, Iekhsan Abas, Faridah Lajis, Nordin H. Naidu, Rakesh Mechanism of apoptosis induced by curcumin in colorectal cancer |
| title | Mechanism of apoptosis induced by curcumin in colorectal cancer |
| title_full | Mechanism of apoptosis induced by curcumin in colorectal cancer |
| title_fullStr | Mechanism of apoptosis induced by curcumin in colorectal cancer |
| title_full_unstemmed | Mechanism of apoptosis induced by curcumin in colorectal cancer |
| title_short | Mechanism of apoptosis induced by curcumin in colorectal cancer |
| title_sort | mechanism of apoptosis induced by curcumin in colorectal cancer |
| url | http://psasir.upm.edu.my/id/eprint/81324/ http://psasir.upm.edu.my/id/eprint/81324/ http://psasir.upm.edu.my/id/eprint/81324/ http://psasir.upm.edu.my/id/eprint/81324/1/Mechanism%20of%20apoptosis%20induced%20by%20curcumin%20in%20colorectal%20cancer.pdf |