Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology
Esters were synthesized via the alcoholysis of red pitaya seed oil with oleyl alcohol catalyzed by immobilized lipase, Lipozyme RM IM. The effects of synthesis parameters, including temperature, time, substrate molar ratio and enzyme loading, on the yield and productivity of esters were assessed usi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Royal Society of Chemistry
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81236/ http://psasir.upm.edu.my/id/eprint/81236/1/PITAYA.pdf |
| _version_ | 1848859055945154560 |
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| author | Abdullah, Asiah Abd Gani, Siti Salwa Yap, Taufiq Yun Hin Abdul Haiyee, Zaibunnisa Zaidan, Uswatun Hasanah Kassim, Mohd Azlan Halmi, Mohd Izuan Effendi |
| author_facet | Abdullah, Asiah Abd Gani, Siti Salwa Yap, Taufiq Yun Hin Abdul Haiyee, Zaibunnisa Zaidan, Uswatun Hasanah Kassim, Mohd Azlan Halmi, Mohd Izuan Effendi |
| author_sort | Abdullah, Asiah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Esters were synthesized via the alcoholysis of red pitaya seed oil with oleyl alcohol catalyzed by immobilized lipase, Lipozyme RM IM. The effects of synthesis parameters, including temperature, time, substrate molar ratio and enzyme loading, on the yield and productivity of esters were assessed using a central composite response surface design. The optimum yield and productivity were predicted to be about 80.00% and 0.58 mmol h−1, respectively, at a synthesis temperature of 50.5 °C, time of 4 h, substrate molar ratio of 3.4 : 1 and with 0.17 g of enzyme. Esters were synthesized under the optimum synthesis conditions; it was found that the average yield and productivity were 82.48 ± 4.57% and 0.62 ± 0.04 mmol h−1, respectively, revealing good correspondence with the predicted values. The main esters were oleyl linoleate, oleyl oleate, oleyl palmitate and oleyl stearate. The synthesized esters exhibited no irritancy effects and their physicochemical properties showed their suitability for use as cosmeceutical ingredients. |
| first_indexed | 2025-11-15T12:23:16Z |
| format | Article |
| id | upm-81236 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:23:16Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-812362021-06-15T23:56:48Z http://psasir.upm.edu.my/id/eprint/81236/ Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology Abdullah, Asiah Abd Gani, Siti Salwa Yap, Taufiq Yun Hin Abdul Haiyee, Zaibunnisa Zaidan, Uswatun Hasanah Kassim, Mohd Azlan Halmi, Mohd Izuan Effendi Esters were synthesized via the alcoholysis of red pitaya seed oil with oleyl alcohol catalyzed by immobilized lipase, Lipozyme RM IM. The effects of synthesis parameters, including temperature, time, substrate molar ratio and enzyme loading, on the yield and productivity of esters were assessed using a central composite response surface design. The optimum yield and productivity were predicted to be about 80.00% and 0.58 mmol h−1, respectively, at a synthesis temperature of 50.5 °C, time of 4 h, substrate molar ratio of 3.4 : 1 and with 0.17 g of enzyme. Esters were synthesized under the optimum synthesis conditions; it was found that the average yield and productivity were 82.48 ± 4.57% and 0.62 ± 0.04 mmol h−1, respectively, revealing good correspondence with the predicted values. The main esters were oleyl linoleate, oleyl oleate, oleyl palmitate and oleyl stearate. The synthesized esters exhibited no irritancy effects and their physicochemical properties showed their suitability for use as cosmeceutical ingredients. Royal Society of Chemistry 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81236/1/PITAYA.pdf Abdullah, Asiah and Abd Gani, Siti Salwa and Yap, Taufiq Yun Hin and Abdul Haiyee, Zaibunnisa and Zaidan, Uswatun Hasanah and Kassim, Mohd Azlan and Halmi, Mohd Izuan Effendi (2019) Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology. RSC Advances, 9 (10). pp. 5599-5609. ISSN 2046-2069 https://pubs.rsc.org/en/content/articlelanding/2019/ra/c8ra09418g#!divAbstract 10.1039/c8ra09418g |
| spellingShingle | Abdullah, Asiah Abd Gani, Siti Salwa Yap, Taufiq Yun Hin Abdul Haiyee, Zaibunnisa Zaidan, Uswatun Hasanah Kassim, Mohd Azlan Halmi, Mohd Izuan Effendi Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| title | Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| title_full | Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| title_fullStr | Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| title_full_unstemmed | Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| title_short | Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| title_sort | lipase-catalyzed synthesis of red pitaya (hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology |
| url | http://psasir.upm.edu.my/id/eprint/81236/ http://psasir.upm.edu.my/id/eprint/81236/ http://psasir.upm.edu.my/id/eprint/81236/ http://psasir.upm.edu.my/id/eprint/81236/1/PITAYA.pdf |