Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales
The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emerg...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81194/ http://psasir.upm.edu.my/id/eprint/81194/1/Lack%20of%20efficacy%20of%20triclabendazole%20against%20Fasciola%20hepatica.pdf |
| _version_ | 1848859047073153024 |
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| author | Kamaludeen, Juriah Brown, John Graham Stephens, Nathalie Miller, Josephine Howell, Alison Beesley, Nicola J Hodgkinson, Jane Learmount, Jane Williams, Diana |
| author_facet | Kamaludeen, Juriah Brown, John Graham Stephens, Nathalie Miller, Josephine Howell, Alison Beesley, Nicola J Hodgkinson, Jane Learmount, Jane Williams, Diana |
| author_sort | Kamaludeen, Juriah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant F hepatica populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. F hepatica eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of F hepatica and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms. |
| first_indexed | 2025-11-15T12:23:07Z |
| format | Article |
| id | upm-81194 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:23:07Z |
| publishDate | 2019 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-811942021-06-20T16:44:29Z http://psasir.upm.edu.my/id/eprint/81194/ Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales Kamaludeen, Juriah Brown, John Graham Stephens, Nathalie Miller, Josephine Howell, Alison Beesley, Nicola J Hodgkinson, Jane Learmount, Jane Williams, Diana The liver fluke Fasciola hepatica is a parasitic trematode that has a major impact on livestock production and human health. Control of F hepatica is difficult and relies on anthelmintics, particularly triclabendazole, due to its efficacy against both adult and juvenile stages of the parasite. Emergence of triclabendazole-resistant F hepatica populations has been reported in a number of countries, including the UK, but the overall prevalence and distribution of triclabendazole resistance is unknown. In this study, the authors established the presence of reduced efficacy of triclabendazole in sheep flocks in England and Wales, using a validated composite faecal egg count reduction test. Seventy-four sheep farms were sampled from Wales, southwest, northwest and northeast England between Autumn 2013 and Spring 2015. F hepatica eggs were detected in samples from 42/74 farms. Evidence of a lack of efficacy of triclabendazole was detected on 21/26 farms on which the faecal egg count reduction test was completed, with faecal egg count reductions ranging from 89 per cent to 0per cent. Regression analysis suggested that both prevalence of F hepatica and lack of efficacy of triclabendazole were spatially correlated, with higher faecal egg counts and lower percentage reductions on farms located in the northwest of England, and Wales. Overall, the results show that reduced efficacy of triclabendazole is present across England and Wales, with a complete lack of therapeutic efficacy observed on 9/26 farms. Wiley 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81194/1/Lack%20of%20efficacy%20of%20triclabendazole%20against%20Fasciola%20hepatica.pdf Kamaludeen, Juriah and Brown, John Graham and Stephens, Nathalie and Miller, Josephine and Howell, Alison and Beesley, Nicola J and Hodgkinson, Jane and Learmount, Jane and Williams, Diana (2019) Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales. Veterinary Record, 184 (16). pp. 502-508. ISSN 0042-4900; ESSN: 2042-7670 https://pubmed.ncbi.nlm.nih.gov/30824600/ 10.1136/vr.105209 |
| spellingShingle | Kamaludeen, Juriah Brown, John Graham Stephens, Nathalie Miller, Josephine Howell, Alison Beesley, Nicola J Hodgkinson, Jane Learmount, Jane Williams, Diana Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales |
| title | Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales |
| title_full | Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales |
| title_fullStr | Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales |
| title_full_unstemmed | Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales |
| title_short | Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales |
| title_sort | lack of efficacy of triclabendazole against fasciola hepatica is present on sheep farms in three regions of england, and wales |
| url | http://psasir.upm.edu.my/id/eprint/81194/ http://psasir.upm.edu.my/id/eprint/81194/ http://psasir.upm.edu.my/id/eprint/81194/ http://psasir.upm.edu.my/id/eprint/81194/1/Lack%20of%20efficacy%20of%20triclabendazole%20against%20Fasciola%20hepatica.pdf |