Development of metal-organic frameworks for biomedical applications - a review
Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs sy...
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| Format: | Article |
| Language: | English |
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Naci kalkan
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81158/ http://psasir.upm.edu.my/id/eprint/81158/1/METAL.pdf |
| _version_ | 1848859039101878272 |
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| author | Mostafa, Yousefzadeh Borzehandani Abdul Malek, Emilia Abdul Rahman, Mohd Basyaruddin Mohammad Latif, Muhammad Alif |
| author_facet | Mostafa, Yousefzadeh Borzehandani Abdul Malek, Emilia Abdul Rahman, Mohd Basyaruddin Mohammad Latif, Muhammad Alif |
| author_sort | Mostafa, Yousefzadeh Borzehandani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs synthesis as well as their toxicological properties. We also highlighted the potential of MOFs as therapeutic agents and nano-MOFs (NMOFs) for biomedical sensing. Water as an alternative media for MOF synthesis showed excellent results in term of particle size, stability and selectivity. Toxicological assessments revealed Fe (III) and
MIL-100 as the most promising metal and MOF for medical applications. It was also shown that MOFs are sensitive towards physiological and pathological criteria such as pH, fluorescence and O2. Although many attempts have been made in utilizing MOFs for bio applications, further improvements should be considered before MOFs can become effective therapeutics options. |
| first_indexed | 2025-11-15T12:23:00Z |
| format | Article |
| id | upm-81158 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:23:00Z |
| publishDate | 2019 |
| publisher | Naci kalkan |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-811582020-09-09T07:42:12Z http://psasir.upm.edu.my/id/eprint/81158/ Development of metal-organic frameworks for biomedical applications - a review Mostafa, Yousefzadeh Borzehandani Abdul Malek, Emilia Abdul Rahman, Mohd Basyaruddin Mohammad Latif, Muhammad Alif Metal-organic frameworks (MOFs) are porous materials made from coordination bonding of organic linkers and metal nodes. Nowadays, MOFs have already achieved a considerable growth in many fields including in bio-related applications. In this review, we focus on the alternative, green route of MOFs synthesis as well as their toxicological properties. We also highlighted the potential of MOFs as therapeutic agents and nano-MOFs (NMOFs) for biomedical sensing. Water as an alternative media for MOF synthesis showed excellent results in term of particle size, stability and selectivity. Toxicological assessments revealed Fe (III) and MIL-100 as the most promising metal and MOF for medical applications. It was also shown that MOFs are sensitive towards physiological and pathological criteria such as pH, fluorescence and O2. Although many attempts have been made in utilizing MOFs for bio applications, further improvements should be considered before MOFs can become effective therapeutics options. Naci kalkan 2019-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/81158/1/METAL.pdf Mostafa, Yousefzadeh Borzehandani and Abdul Malek, Emilia and Abdul Rahman, Mohd Basyaruddin and Mohammad Latif, Muhammad Alif (2019) Development of metal-organic frameworks for biomedical applications - a review. Journal of Multidisciplinary Engineering Science and Technology, 6 (12). art. no. 42353068. pp. 105-116. ISSN 2458-9403 http://www.jmest.org/wp-content/uploads/JMESTN42353068.pdf |
| spellingShingle | Mostafa, Yousefzadeh Borzehandani Abdul Malek, Emilia Abdul Rahman, Mohd Basyaruddin Mohammad Latif, Muhammad Alif Development of metal-organic frameworks for biomedical applications - a review |
| title | Development of metal-organic frameworks for biomedical applications - a review |
| title_full | Development of metal-organic frameworks for biomedical applications - a review |
| title_fullStr | Development of metal-organic frameworks for biomedical applications - a review |
| title_full_unstemmed | Development of metal-organic frameworks for biomedical applications - a review |
| title_short | Development of metal-organic frameworks for biomedical applications - a review |
| title_sort | development of metal-organic frameworks for biomedical applications - a review |
| url | http://psasir.upm.edu.my/id/eprint/81158/ http://psasir.upm.edu.my/id/eprint/81158/ http://psasir.upm.edu.my/id/eprint/81158/1/METAL.pdf |