Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system
The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spect...
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| Format: | Article |
| Language: | English |
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WILEY-VCH Verlag
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80914/ http://psasir.upm.edu.my/id/eprint/80914/1/OROTATE.pdf |
| _version_ | 1848858979626647552 |
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| author | Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita |
| author_facet | Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita |
| author_sort | Abdelkader, Hassani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, X‐ray diffraction, transmission electron microscopy, and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy. MgOr was successfully encapsulated into the CS cavity. Results with 3‐(4,5‐dimethylthiazol‐2‐yl)2,5‐diphenyl tetrazolium bromide indicated that MgOrCSNPs retained their cytotoxic activity against the liver cancer cell line (HepG2) and breast cancer cell line (MCF‐7), and low toxicity against the human cell line (3T3) and human retinal epithelial cell line (ARPE‐19). |
| first_indexed | 2025-11-15T12:22:03Z |
| format | Article |
| id | upm-80914 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:22:03Z |
| publishDate | 2019 |
| publisher | WILEY-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-809142020-10-14T21:22:47Z http://psasir.upm.edu.my/id/eprint/80914/ Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita The drug release properties of magnesium orotate (MgOr) encapsulated in the chitosan (CS) cavity and the complexation behavior between MgOr and CS were investigated. The MgOr‐loaded CS nanoparticles (MgOrCSNPs) were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, X‐ray diffraction, transmission electron microscopy, and scanning electron microscopy with energy‐dispersive X‐ray spectroscopy. MgOr was successfully encapsulated into the CS cavity. Results with 3‐(4,5‐dimethylthiazol‐2‐yl)2,5‐diphenyl tetrazolium bromide indicated that MgOrCSNPs retained their cytotoxic activity against the liver cancer cell line (HepG2) and breast cancer cell line (MCF‐7), and low toxicity against the human cell line (3T3) and human retinal epithelial cell line (ARPE‐19). WILEY-VCH Verlag 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80914/1/OROTATE.pdf Abdelkader, Hassani and Hussain, Siti Aslina and Abdullah, Norhafizah and Kamarudin, Suryani and Rosli, Rozita (2019) Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system. Chemical Engineering & Technology, 42 (9). pp. 1816-1824. ISSN 0930-7516; ESSN: 1521-4125 https://onlinelibrary.wiley.com/doi/full/10.1002/ceat.201800478 10.1002/ceat.201800478 |
| spellingShingle | Abdelkader, Hassani Hussain, Siti Aslina Abdullah, Norhafizah Kamarudin, Suryani Rosli, Rozita Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| title | Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| title_full | Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| title_fullStr | Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| title_full_unstemmed | Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| title_short | Characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| title_sort | characterization of magnesium orotate-loaded chitosan polymer nanoparticle for drug delivery system |
| url | http://psasir.upm.edu.my/id/eprint/80914/ http://psasir.upm.edu.my/id/eprint/80914/ http://psasir.upm.edu.my/id/eprint/80914/ http://psasir.upm.edu.my/id/eprint/80914/1/OROTATE.pdf |