Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders
The human brain is made up of billions of neurons and glial cells which are interconnected and organized into specific patterns of neural circuitry, and hence is arguably the most sophisticated organ in human, both structurally and functionally. Studying the underlying mechanisms responsible for neu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Neurotak Publishing
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80883/ http://psasir.upm.edu.my/id/eprint/80883/1/3D.pdf |
| _version_ | 1848858973288005632 |
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| author | Cheah, Pike See Mason, John O. Ling, King Hwa |
| author_facet | Cheah, Pike See Mason, John O. Ling, King Hwa |
| author_sort | Cheah, Pike See |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The human brain is made up of billions of neurons and glial cells which are interconnected and organized into specific patterns of neural circuitry, and hence is arguably the most sophisticated organ in human, both structurally and functionally. Studying the underlying mechanisms responsible for neurological or neurodegenerative disorders and the developmental basis of complex brain diseases such as autism, schizophrenia, bipolar disorder, Alzheimer’s and Parkinson’s disease has proven challenging due to practical and ethical limitations on experiments with human material and the limitations of existing biological/animal models. Recently, cerebral organoids have been proposed as a promising and revolutionary model for understanding complex brain disorders and preclinical drug screening. |
| first_indexed | 2025-11-15T12:21:57Z |
| format | Article |
| id | upm-80883 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:21:57Z |
| publishDate | 2019 |
| publisher | Neurotak Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-808832020-10-15T22:48:52Z http://psasir.upm.edu.my/id/eprint/80883/ Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders Cheah, Pike See Mason, John O. Ling, King Hwa The human brain is made up of billions of neurons and glial cells which are interconnected and organized into specific patterns of neural circuitry, and hence is arguably the most sophisticated organ in human, both structurally and functionally. Studying the underlying mechanisms responsible for neurological or neurodegenerative disorders and the developmental basis of complex brain diseases such as autism, schizophrenia, bipolar disorder, Alzheimer’s and Parkinson’s disease has proven challenging due to practical and ethical limitations on experiments with human material and the limitations of existing biological/animal models. Recently, cerebral organoids have been proposed as a promising and revolutionary model for understanding complex brain disorders and preclinical drug screening. Neurotak Publishing 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80883/1/3D.pdf Cheah, Pike See and Mason, John O. and Ling, King Hwa (2019) Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders. Neuroscience Research Notes, 2 (1). pp. 1-6. ISSN 2576-828X https://neuroscirn.org/ojs/index.php/nrnotes/article/view/28 10.31117/neuroscirn.v2i1.28 |
| spellingShingle | Cheah, Pike See Mason, John O. Ling, King Hwa Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders |
| title | Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders |
| title_full | Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders |
| title_fullStr | Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders |
| title_full_unstemmed | Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders |
| title_short | Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders |
| title_sort | challenges and future perspectives for 3d cerebral organoids as a model for complex brain disorders |
| url | http://psasir.upm.edu.my/id/eprint/80883/ http://psasir.upm.edu.my/id/eprint/80883/ http://psasir.upm.edu.my/id/eprint/80883/ http://psasir.upm.edu.my/id/eprint/80883/1/3D.pdf |