Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology
Nanoemulsions have been used as a drug carrier system, particularly for poorly water-soluble drugs. Sorafenib is a poorly soluble drug and also there is no parenteral treatment. The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib. The formulations...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2019
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/80195/ http://psasir.upm.edu.my/id/eprint/80195/1/Improvement%20of%20physicochemical%20properties%20of%20nanocolloidal%20carrier%20loaded%20with%20low%20water%20solubility%20drug%20for%20parenteral%20cancer%20treatment%20by%20response%20surface%20methodology.pdf |
| _version_ | 1848858853378097152 |
|---|---|
| author | Salim, Norazlinaliza Karjiban, Roghayeh Abedi Basri, Mahiran Masoumi, Hamid Reza Fard |
| author_facet | Salim, Norazlinaliza Karjiban, Roghayeh Abedi Basri, Mahiran Masoumi, Hamid Reza Fard |
| author_sort | Salim, Norazlinaliza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nanoemulsions have been used as a drug carrier system, particularly for poorly water-soluble drugs. Sorafenib is
a poorly soluble drug and also there is no parenteral treatment. The aim of this study is the development of
nanoemulsions for intravenous administration of Sorafenib. The formulations were prepared by high energy
emulsification method and optimized by using Response Surface Methodology (RSM). Here, the effect of independent
composition variables of lecithin (1.16–2.84%, w/w), Medium-Chain Triglycerides (2.32–5.68%, w/ w) and polysorbate 80 (0.58–1.42%, w/w) amounts on the properties of Sorafenib-loaded nanoemulsion was investigated. The three responses variables were particle size, zeta potential, and polydispersity index. Optimization of the conditions according to the three dependent variables was performed for the preparation of
the Sorafenib-loaded nanoemulsions with the minimum value of particle size, suitable rage of zeta potential, and
polydispersity index. A formulation containing 0.05% of Sorafenib kept its properties in a satisfactory range over
the evaluated period. The composition with 3% Medium-Chain Triglycerides, 2.5% lecithin and 1.22% polysorbate
80 exhibited the smallest particle size and polydispersity index (43.17 nm and 0.22, respectively) with
the zeta potential of −38.8 mV was the optimized composition. The fabricated nanoemulsion was characterized
by the transmission electron microscope (TEM), viscosity, and stability assessment study. Also, the cytotoxicity
result showed that the optimum formulations had no significant effect on a normal cell in a low concentration of
the drug but could eliminate the cancer cells. The dose-dependent toxicity made it a suitable candidate for
parenteral applications in the treatment of breast cancer. Furthermore, the optimized formulation indicated
good storage stability for 3 months at different temperatures (4 ± 2 °C, 25 ± 2 °C and 45 ± 2 °C. |
| first_indexed | 2025-11-15T12:20:03Z |
| format | Article |
| id | upm-80195 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:20:03Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-801952020-10-02T00:10:00Z http://psasir.upm.edu.my/id/eprint/80195/ Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology Salim, Norazlinaliza Karjiban, Roghayeh Abedi Basri, Mahiran Masoumi, Hamid Reza Fard Nanoemulsions have been used as a drug carrier system, particularly for poorly water-soluble drugs. Sorafenib is a poorly soluble drug and also there is no parenteral treatment. The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib. The formulations were prepared by high energy emulsification method and optimized by using Response Surface Methodology (RSM). Here, the effect of independent composition variables of lecithin (1.16–2.84%, w/w), Medium-Chain Triglycerides (2.32–5.68%, w/ w) and polysorbate 80 (0.58–1.42%, w/w) amounts on the properties of Sorafenib-loaded nanoemulsion was investigated. The three responses variables were particle size, zeta potential, and polydispersity index. Optimization of the conditions according to the three dependent variables was performed for the preparation of the Sorafenib-loaded nanoemulsions with the minimum value of particle size, suitable rage of zeta potential, and polydispersity index. A formulation containing 0.05% of Sorafenib kept its properties in a satisfactory range over the evaluated period. The composition with 3% Medium-Chain Triglycerides, 2.5% lecithin and 1.22% polysorbate 80 exhibited the smallest particle size and polydispersity index (43.17 nm and 0.22, respectively) with the zeta potential of −38.8 mV was the optimized composition. The fabricated nanoemulsion was characterized by the transmission electron microscope (TEM), viscosity, and stability assessment study. Also, the cytotoxicity result showed that the optimum formulations had no significant effect on a normal cell in a low concentration of the drug but could eliminate the cancer cells. The dose-dependent toxicity made it a suitable candidate for parenteral applications in the treatment of breast cancer. Furthermore, the optimized formulation indicated good storage stability for 3 months at different temperatures (4 ± 2 °C, 25 ± 2 °C and 45 ± 2 °C. 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80195/1/Improvement%20of%20physicochemical%20properties%20of%20nanocolloidal%20carrier%20loaded%20with%20low%20water%20solubility%20drug%20for%20parenteral%20cancer%20treatment%20by%20response%20surface%20methodology.pdf Salim, Norazlinaliza and Karjiban, Roghayeh Abedi and Basri, Mahiran and Masoumi, Hamid Reza Fard (2019) Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology. Materials Science & Engineering C-Materials for Biological Applications, 94 (2019). pp. 841-849. https://www.researchgate.net/publication/328081576_Improvement_of_physicochemical_properties_of_nanocolloidal_carrier_loaded_with_low_water_solubility_drug_for_parenteral_cancer_treatment_by_Response_Surface_Methodology 10.1016/j.msec.2018.10.015 |
| spellingShingle | Salim, Norazlinaliza Karjiban, Roghayeh Abedi Basri, Mahiran Masoumi, Hamid Reza Fard Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| title | Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| title_full | Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| title_fullStr | Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| title_full_unstemmed | Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| title_short | Improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| title_sort | improvement of physicochemical properties of nanocolloidal carrier loaded with low water solubility drug for parenteral cancer treatment by response surface methodology |
| url | http://psasir.upm.edu.my/id/eprint/80195/ http://psasir.upm.edu.my/id/eprint/80195/ http://psasir.upm.edu.my/id/eprint/80195/ http://psasir.upm.edu.my/id/eprint/80195/1/Improvement%20of%20physicochemical%20properties%20of%20nanocolloidal%20carrier%20loaded%20with%20low%20water%20solubility%20drug%20for%20parenteral%20cancer%20treatment%20by%20response%20surface%20methodology.pdf |