Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza
Curcuma xanthorrhiza is a natural source of traditional medicines with numerous biological properties. This study profiles the metabolites in different fractions (hexane, chloroform, ethyl acetate and methanol) of the ethanolic extracts of C. xanthorrhiza using a nuclear magnetic resonance-based m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/80135/ http://psasir.upm.edu.my/id/eprint/80135/1/Identification%20of%20nitric%20oxide%20inhibitory%20compounds%20from%20the%20rhizome%20of%20Curcuma%20xanthorrhiza.pdf |
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| author | Awin, Tahani M. Buzgaia, Nawal Abd Ghafar, Siti Zulaikha Mediani, Ahmed Mohd Zaudzi, Siti Munirah Maulidiani, M. Shaari, Khozirah Abas, Faridah |
| author_facet | Awin, Tahani M. Buzgaia, Nawal Abd Ghafar, Siti Zulaikha Mediani, Ahmed Mohd Zaudzi, Siti Munirah Maulidiani, M. Shaari, Khozirah Abas, Faridah |
| author_sort | Awin, Tahani M. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Curcuma xanthorrhiza is a natural source of traditional medicines with numerous biological properties. This
study profiles the metabolites in different fractions (hexane, chloroform, ethyl acetate and methanol) of the
ethanolic extracts of C. xanthorrhiza using a nuclear magnetic resonance-based metabolomics approach. The
nitric oxide (NO) inhibitory activity was determined using a Griess assay. The bioactivity and phytochemical
constituents were correlated using partial least squares regression that indicated the differences between the 4
solvents based on the identified metabolites and their bioactivities. The results showed that the ethyl acetate
fractions of C. xanthorrhiza had the highest NO inhibitory activity, this high activity is associated with the large
quantity of curcuminoids found in this fraction. The metabolites that are responsible for the bioactivity are
curcumin, demethoxycurcumin, l-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-6-heptene-3,5-dione, and 1-(4-
hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione. Ultra-performance
liquid chromatography–tandem mass spectrometry was used to identify more metabolites in the active fraction,
including bisdemethoxycurcumin and 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-diol. The findings suggested
that the ethyl acetate fraction of C. xanthorrhiza showed significant activity and can be a potential natural
source of NO inhibitors. |
| first_indexed | 2025-11-15T12:19:48Z |
| format | Article |
| id | upm-80135 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:19:48Z |
| publishDate | 2019 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-801352020-09-23T08:01:17Z http://psasir.upm.edu.my/id/eprint/80135/ Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza Awin, Tahani M. Buzgaia, Nawal Abd Ghafar, Siti Zulaikha Mediani, Ahmed Mohd Zaudzi, Siti Munirah Maulidiani, M. Shaari, Khozirah Abas, Faridah Curcuma xanthorrhiza is a natural source of traditional medicines with numerous biological properties. This study profiles the metabolites in different fractions (hexane, chloroform, ethyl acetate and methanol) of the ethanolic extracts of C. xanthorrhiza using a nuclear magnetic resonance-based metabolomics approach. The nitric oxide (NO) inhibitory activity was determined using a Griess assay. The bioactivity and phytochemical constituents were correlated using partial least squares regression that indicated the differences between the 4 solvents based on the identified metabolites and their bioactivities. The results showed that the ethyl acetate fractions of C. xanthorrhiza had the highest NO inhibitory activity, this high activity is associated with the large quantity of curcuminoids found in this fraction. The metabolites that are responsible for the bioactivity are curcumin, demethoxycurcumin, l-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-6-heptene-3,5-dione, and 1-(4- hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione. Ultra-performance liquid chromatography–tandem mass spectrometry was used to identify more metabolites in the active fraction, including bisdemethoxycurcumin and 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-diol. The findings suggested that the ethyl acetate fraction of C. xanthorrhiza showed significant activity and can be a potential natural source of NO inhibitors. Elsevier BV 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/80135/1/Identification%20of%20nitric%20oxide%20inhibitory%20compounds%20from%20the%20rhizome%20of%20Curcuma%20xanthorrhiza.pdf Awin, Tahani M. and Buzgaia, Nawal and Abd Ghafar, Siti Zulaikha and Mediani, Ahmed and Mohd Zaudzi, Siti Munirah and Maulidiani, M. and Shaari, Khozirah and Abas, Faridah (2019) Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza. Food Bioscience, 29. pp. 126-134. ISSN 2212-4292; ESSN: 2212-4306 10.1016/j.fbio.2019.04.009 |
| spellingShingle | Awin, Tahani M. Buzgaia, Nawal Abd Ghafar, Siti Zulaikha Mediani, Ahmed Mohd Zaudzi, Siti Munirah Maulidiani, M. Shaari, Khozirah Abas, Faridah Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza |
| title | Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza |
| title_full | Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza |
| title_fullStr | Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza |
| title_full_unstemmed | Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza |
| title_short | Identification of nitric oxide inhibitory compounds from the rhizome of Curcuma xanthorrhiza |
| title_sort | identification of nitric oxide inhibitory compounds from the rhizome of curcuma xanthorrhiza |
| url | http://psasir.upm.edu.my/id/eprint/80135/ http://psasir.upm.edu.my/id/eprint/80135/ http://psasir.upm.edu.my/id/eprint/80135/1/Identification%20of%20nitric%20oxide%20inhibitory%20compounds%20from%20the%20rhizome%20of%20Curcuma%20xanthorrhiza.pdf |