Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review
Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NFκB). NFκB activation initiates the canonica...
| Main Authors: | , , , , , |
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| Format: | Article |
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Frontiers Research Foundation
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/79916/ |
| _version_ | 1848858786302787584 |
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| author | Choy, Ker Woon Murugan, Dharmani Leong, Xin Fang Abas, Razif Alias, Aspalilah Mustafa, Mohd Rais |
| author_facet | Choy, Ker Woon Murugan, Dharmani Leong, Xin Fang Abas, Razif Alias, Aspalilah Mustafa, Mohd Rais |
| author_sort | Choy, Ker Woon |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NFκB). NFκB activation initiates the canonical and non-conical pathways that promotes activation of transcription factors leading to inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. Flavonoids are bioactive polyphenolic compounds found abundantly in various fruits, vegetables, beverages (tea, coffee), nuts, and cereal products with cardiovascular protective properties. Flavonoids can be classified into six subgroups based on their chemical structures: flavanones, flavones, flavonols, flavan-3-ols, isoflavones, and anthocyanidins. As NFκB inhibitors, these flavonoids may modulate the expression of pro-inflammatory genes leading to the attenuation of the inflammatory responses underlying various cardiovascular pathology. This review presents an update on the anti-inflammatory actions of flavonoids via inhibition of NFκB mechanism supporting the therapeutic potential of these natural compounds in various CVDs. |
| first_indexed | 2025-11-15T12:18:59Z |
| format | Article |
| id | upm-79916 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T12:18:59Z |
| publishDate | 2019 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-799162023-03-24T03:48:06Z http://psasir.upm.edu.my/id/eprint/79916/ Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review Choy, Ker Woon Murugan, Dharmani Leong, Xin Fang Abas, Razif Alias, Aspalilah Mustafa, Mohd Rais Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NFκB). NFκB activation initiates the canonical and non-conical pathways that promotes activation of transcription factors leading to inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. Flavonoids are bioactive polyphenolic compounds found abundantly in various fruits, vegetables, beverages (tea, coffee), nuts, and cereal products with cardiovascular protective properties. Flavonoids can be classified into six subgroups based on their chemical structures: flavanones, flavones, flavonols, flavan-3-ols, isoflavones, and anthocyanidins. As NFκB inhibitors, these flavonoids may modulate the expression of pro-inflammatory genes leading to the attenuation of the inflammatory responses underlying various cardiovascular pathology. This review presents an update on the anti-inflammatory actions of flavonoids via inhibition of NFκB mechanism supporting the therapeutic potential of these natural compounds in various CVDs. Frontiers Research Foundation 2019 Article PeerReviewed Choy, Ker Woon and Murugan, Dharmani and Leong, Xin Fang and Abas, Razif and Alias, Aspalilah and Mustafa, Mohd Rais (2019) Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review. Frontiers in Pharmacology, 10. pp. 1-8. ISSN 1663-9812 https://www.frontiersin.org/articles/10.3389/fphar.2019.01295/full 10.3389/fphar.2019.01295 |
| spellingShingle | Choy, Ker Woon Murugan, Dharmani Leong, Xin Fang Abas, Razif Alias, Aspalilah Mustafa, Mohd Rais Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review |
| title | Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review |
| title_full | Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review |
| title_fullStr | Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review |
| title_full_unstemmed | Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review |
| title_short | Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signalling in cardiovascular diseases: a mini review |
| title_sort | flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa b (nfκb) signalling in cardiovascular diseases: a mini review |
| url | http://psasir.upm.edu.my/id/eprint/79916/ http://psasir.upm.edu.my/id/eprint/79916/ http://psasir.upm.edu.my/id/eprint/79916/ |