Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles
The excessive use of fungicides may be of environmental and health concerns. Hence, to overcome this problem, chitosan as a controlled release matrix was used in this work to encapsulate the fungicide for the development of enhanced fungicide nanodelivery system. In this proposed study, dual-loaded...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2019
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/79685/ http://psasir.upm.edu.my/id/eprint/79685/1/Enhanced%20fungicidal%20efficacy%20.pdf |
| _version_ | 1848858735287468032 |
|---|---|
| author | Maluin, Farhatun Najat Hussein, Mohd Zobir Yusof, Nor Azah Fakurazi, Sharida Abu Seman, Idris Zainol Hilmi, Nur Hailini Jeffery Daim, Leona Daniela |
| author_facet | Maluin, Farhatun Najat Hussein, Mohd Zobir Yusof, Nor Azah Fakurazi, Sharida Abu Seman, Idris Zainol Hilmi, Nur Hailini Jeffery Daim, Leona Daniela |
| author_sort | Maluin, Farhatun Najat |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The excessive use of fungicides may be of environmental and health concerns. Hence, to overcome this problem, chitosan as a controlled release matrix was used in this work to encapsulate the fungicide for the development of enhanced fungicide nanodelivery system. In this proposed study, dual-loaded fungicides (hexaconazole and dazomet) were simultaneously encapsulated into chitosan nanoparticles as an antifungal agent on Ganoderma boninense (G. boninense). In this work, we report the synthesis and characterization of the nanoparticles prepared using various concentrations of the crosslinking agent of sodium tripolyphosphate (TPP); 2.5, 5, 10, and 20 mg mL−1, which resulted in the nanoparticles of CHDEN2.5, CHDEN5, CHDEN10, and CHDEN20, respectively. The effect of TPP on the synthesized nanoparticle size revealed that an increase of TPP resulted in smaller particles, which in turn play a crucial role in controlling G. boninense growth. CHDEN20 shows the highest antifungal efficacy with the lowest half-maximal effective concentration (EC50) on G. boninense. The formulated nanocarrier system of fungicide aims to enhance the efficient delivery of the active ingredients to the target site, able to sustain in it for a longer time, and consequently improve the fungicide efficacy in combating the basal stem rot disease in oil palm. |
| first_indexed | 2025-11-15T12:18:10Z |
| format | Article |
| id | upm-79685 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:18:10Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-796852022-10-05T02:37:14Z http://psasir.upm.edu.my/id/eprint/79685/ Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles Maluin, Farhatun Najat Hussein, Mohd Zobir Yusof, Nor Azah Fakurazi, Sharida Abu Seman, Idris Zainol Hilmi, Nur Hailini Jeffery Daim, Leona Daniela The excessive use of fungicides may be of environmental and health concerns. Hence, to overcome this problem, chitosan as a controlled release matrix was used in this work to encapsulate the fungicide for the development of enhanced fungicide nanodelivery system. In this proposed study, dual-loaded fungicides (hexaconazole and dazomet) were simultaneously encapsulated into chitosan nanoparticles as an antifungal agent on Ganoderma boninense (G. boninense). In this work, we report the synthesis and characterization of the nanoparticles prepared using various concentrations of the crosslinking agent of sodium tripolyphosphate (TPP); 2.5, 5, 10, and 20 mg mL−1, which resulted in the nanoparticles of CHDEN2.5, CHDEN5, CHDEN10, and CHDEN20, respectively. The effect of TPP on the synthesized nanoparticle size revealed that an increase of TPP resulted in smaller particles, which in turn play a crucial role in controlling G. boninense growth. CHDEN20 shows the highest antifungal efficacy with the lowest half-maximal effective concentration (EC50) on G. boninense. The formulated nanocarrier system of fungicide aims to enhance the efficient delivery of the active ingredients to the target site, able to sustain in it for a longer time, and consequently improve the fungicide efficacy in combating the basal stem rot disease in oil palm. Royal Society of Chemistry 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79685/1/Enhanced%20fungicidal%20efficacy%20.pdf Maluin, Farhatun Najat and Hussein, Mohd Zobir and Yusof, Nor Azah and Fakurazi, Sharida and Abu Seman, Idris and Zainol Hilmi, Nur Hailini and Jeffery Daim, Leona Daniela (2019) Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles. RSC Advances, 9. pp. 27083-27095. ISSN 2046-2069 https://pubs.rsc.org/en/content/articlehtml/2019/ra/c9ra05417k 10.1039/C9RA05417K |
| spellingShingle | Maluin, Farhatun Najat Hussein, Mohd Zobir Yusof, Nor Azah Fakurazi, Sharida Abu Seman, Idris Zainol Hilmi, Nur Hailini Jeffery Daim, Leona Daniela Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| title | Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| title_full | Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| title_fullStr | Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| title_full_unstemmed | Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| title_short | Enhanced fungicidal efficacy on Ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| title_sort | enhanced fungicidal efficacy on ganoderma boninense by simultaneous co-delivery of hexaconazole and dazomet from their chitosan nanoparticles |
| url | http://psasir.upm.edu.my/id/eprint/79685/ http://psasir.upm.edu.my/id/eprint/79685/ http://psasir.upm.edu.my/id/eprint/79685/ http://psasir.upm.edu.my/id/eprint/79685/1/Enhanced%20fungicidal%20efficacy%20.pdf |