Efficacy and potential of phage therapy against multidrug resistant Shigella spp.
Shigella-infected bacillary dysentery or commonly known as Shigellosis is a leading cause of morbidity and mortality worldwide. The gradual emergence of multidrug resistant Shigella spp. has triggered the search for alternatives to conventional antibiotics. Phage therapy could be one such suitable a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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2167-8359
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/79636/ http://psasir.upm.edu.my/id/eprint/79636/1/Efficacy%20and%20potential%20of%20phage%20therapy%20against%20multidrug%20resistant%20Shigella%20spp.pdf |
| _version_ | 1848858724738793472 |
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| author | Tang, Swee Seong Biswas, Sudhangshu Kumar Tan, Wen Siang Saha, Ananda Kumar Wei, Bey Fenh |
| author_facet | Tang, Swee Seong Biswas, Sudhangshu Kumar Tan, Wen Siang Saha, Ananda Kumar Wei, Bey Fenh |
| author_sort | Tang, Swee Seong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Shigella-infected bacillary dysentery or commonly known as Shigellosis is a leading cause of morbidity and mortality worldwide. The gradual emergence of multidrug resistant Shigella spp. has triggered the search for alternatives to conventional antibiotics. Phage therapy could be one such suitable alternative, given its proven long term safety profile as well as the rapid expansion of phage therapy research. To be successful, phage therapy will need an adequate regulatory framework, effective strategies, the proper selection of appropriate phages, early solutions to overcome phage therapy limitations, the implementation of safety protocols, and finally improved public awareness. To achieve all these criteria and successfully apply phage therapy against multidrug resistant shigellosis, a comprehensive study is required. In fact, a variety of phage-based approaches and products including single phages, phage cocktails, mutated phages, genetically engineered phages, and combinations of phages with antibiotics have already been carried out to test the applications of phage therapy against multidrug resistant Shigella. This review provides a broad survey of phage treatments from past to present, focusing on the history, applications, limitations and effective solutions related to, as well as the prospects for, the use of phage therapy against multidrug resistant Shigella spp. and other multidrug resistant bacterial pathogens. |
| first_indexed | 2025-11-15T12:18:00Z |
| format | Article |
| id | upm-79636 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:18:00Z |
| publishDate | 2019 |
| publisher | 2167-8359 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-796362021-08-19T00:03:16Z http://psasir.upm.edu.my/id/eprint/79636/ Efficacy and potential of phage therapy against multidrug resistant Shigella spp. Tang, Swee Seong Biswas, Sudhangshu Kumar Tan, Wen Siang Saha, Ananda Kumar Wei, Bey Fenh Shigella-infected bacillary dysentery or commonly known as Shigellosis is a leading cause of morbidity and mortality worldwide. The gradual emergence of multidrug resistant Shigella spp. has triggered the search for alternatives to conventional antibiotics. Phage therapy could be one such suitable alternative, given its proven long term safety profile as well as the rapid expansion of phage therapy research. To be successful, phage therapy will need an adequate regulatory framework, effective strategies, the proper selection of appropriate phages, early solutions to overcome phage therapy limitations, the implementation of safety protocols, and finally improved public awareness. To achieve all these criteria and successfully apply phage therapy against multidrug resistant shigellosis, a comprehensive study is required. In fact, a variety of phage-based approaches and products including single phages, phage cocktails, mutated phages, genetically engineered phages, and combinations of phages with antibiotics have already been carried out to test the applications of phage therapy against multidrug resistant Shigella. This review provides a broad survey of phage treatments from past to present, focusing on the history, applications, limitations and effective solutions related to, as well as the prospects for, the use of phage therapy against multidrug resistant Shigella spp. and other multidrug resistant bacterial pathogens. 2167-8359 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79636/1/Efficacy%20and%20potential%20of%20phage%20therapy%20against%20multidrug%20resistant%20Shigella%20spp.pdf Tang, Swee Seong and Biswas, Sudhangshu Kumar and Tan, Wen Siang and Saha, Ananda Kumar and Wei, Bey Fenh (2019) Efficacy and potential of phage therapy against multidrug resistant Shigella spp. PeerJ, 7. ISSN 2167-8359 https://peerj.com/articles/6225/ 10.7717/peerj.6225 |
| spellingShingle | Tang, Swee Seong Biswas, Sudhangshu Kumar Tan, Wen Siang Saha, Ananda Kumar Wei, Bey Fenh Efficacy and potential of phage therapy against multidrug resistant Shigella spp. |
| title | Efficacy and potential of phage therapy against multidrug resistant Shigella spp. |
| title_full | Efficacy and potential of phage therapy against multidrug resistant Shigella spp. |
| title_fullStr | Efficacy and potential of phage therapy against multidrug resistant Shigella spp. |
| title_full_unstemmed | Efficacy and potential of phage therapy against multidrug resistant Shigella spp. |
| title_short | Efficacy and potential of phage therapy against multidrug resistant Shigella spp. |
| title_sort | efficacy and potential of phage therapy against multidrug resistant shigella spp. |
| url | http://psasir.upm.edu.my/id/eprint/79636/ http://psasir.upm.edu.my/id/eprint/79636/ http://psasir.upm.edu.my/id/eprint/79636/ http://psasir.upm.edu.my/id/eprint/79636/1/Efficacy%20and%20potential%20of%20phage%20therapy%20against%20multidrug%20resistant%20Shigella%20spp.pdf |