Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians
Introduction: Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Yellow-stripe scad (YSS) on the other hand, is a local Malaysian fish which can be a good substitute for salmon; however, the th...
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| Format: | Article |
| Language: | English |
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Biome Scientia
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/79589/ http://psasir.upm.edu.my/id/eprint/79589/1/Effects%20of%20EPA%2BDHA%20.pdf |
| _version_ | 1848858715013251072 |
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| author | AbdulRahman, Yakubu Azlan, Azrina Loh, Su Peng Ismail, Irmi Zarina Md Noor, Sabariah |
| author_facet | AbdulRahman, Yakubu Azlan, Azrina Loh, Su Peng Ismail, Irmi Zarina Md Noor, Sabariah |
| author_sort | AbdulRahman, Yakubu |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Yellow-stripe scad (YSS) on the other hand, is a local Malaysian fish which can be a good substitute for salmon; however, the therapeutic effects of YSS is still unclear. Objective: Therefore, this study compared the nutritional values EPA+DHA of YSS and salmon on body mass index (BMI), leptin and activation markers for both platelet and endothelial cell. Methods: Healthy overweight Malaysian adults (n=45), aged 21-55 years old, were recruited for 6-months cross-over trial study. They were randomised equally to receive eight weeks of either steamed whole YSS fish or salmon fillet, for three days per week, obtaining approximately 7000 mg EPA+DHA weekly. The diets were switched after an eight-week washout period. Baseline dietary fish intakes were similar in the two groups. Results: Significant differences observed in serum leptin for YSS-baseline group I and salmon-baseline group II (p<0.05). Significant changes were observed in serum P-selectin, sCD40L and IL-1β in YSS-baseline group I (p<0.05) but not in VCAM-1 (p>0.05). Significant decreased were also observed in serum vWF and VCAM-I in salmon/baseline group II (p<0.05), but not in P-selectin, sCD40L and IL-1β (p>0.05). However, there was no significant differences between YSS and salmon (P>0.05) on time and treatment in all variable after 16 week, but there was a significant effect of treatment on sCD40L from YSS and vWF from salmon (p<0.05) Conclusion: Both YSS and salmon could harmonized EPA+DHA into leptin, platelet and endothelial phospholipid membrane to decreased platelet and endothelial cell activation markers which may contribute to the cardioprotective effect of EPA +DHA. Thus, the health benefits of YSS fish “ikan selar” and salmon on leptin and prothrombotic parameter on healthy overweight adults may be similar. |
| first_indexed | 2025-11-15T12:17:51Z |
| format | Article |
| id | upm-79589 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:17:51Z |
| publishDate | 2019 |
| publisher | Biome Scientia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-795892021-06-30T10:56:42Z http://psasir.upm.edu.my/id/eprint/79589/ Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians AbdulRahman, Yakubu Azlan, Azrina Loh, Su Peng Ismail, Irmi Zarina Md Noor, Sabariah Introduction: Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Yellow-stripe scad (YSS) on the other hand, is a local Malaysian fish which can be a good substitute for salmon; however, the therapeutic effects of YSS is still unclear. Objective: Therefore, this study compared the nutritional values EPA+DHA of YSS and salmon on body mass index (BMI), leptin and activation markers for both platelet and endothelial cell. Methods: Healthy overweight Malaysian adults (n=45), aged 21-55 years old, were recruited for 6-months cross-over trial study. They were randomised equally to receive eight weeks of either steamed whole YSS fish or salmon fillet, for three days per week, obtaining approximately 7000 mg EPA+DHA weekly. The diets were switched after an eight-week washout period. Baseline dietary fish intakes were similar in the two groups. Results: Significant differences observed in serum leptin for YSS-baseline group I and salmon-baseline group II (p<0.05). Significant changes were observed in serum P-selectin, sCD40L and IL-1β in YSS-baseline group I (p<0.05) but not in VCAM-1 (p>0.05). Significant decreased were also observed in serum vWF and VCAM-I in salmon/baseline group II (p<0.05), but not in P-selectin, sCD40L and IL-1β (p>0.05). However, there was no significant differences between YSS and salmon (P>0.05) on time and treatment in all variable after 16 week, but there was a significant effect of treatment on sCD40L from YSS and vWF from salmon (p<0.05) Conclusion: Both YSS and salmon could harmonized EPA+DHA into leptin, platelet and endothelial phospholipid membrane to decreased platelet and endothelial cell activation markers which may contribute to the cardioprotective effect of EPA +DHA. Thus, the health benefits of YSS fish “ikan selar” and salmon on leptin and prothrombotic parameter on healthy overweight adults may be similar. Biome Scientia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79589/1/Effects%20of%20EPA%2BDHA%20.pdf AbdulRahman, Yakubu and Azlan, Azrina and Loh, Su Peng and Ismail, Irmi Zarina and Md Noor, Sabariah (2019) Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians. Life Sciences, Medicine and Biomedicine, 3 (8). pp. 1-10. ISSN 2600-7207 https://biomescientia.com/index.php/lsmb/article/view/28 10.28916/lsmb.3.8.2019.28 |
| spellingShingle | AbdulRahman, Yakubu Azlan, Azrina Loh, Su Peng Ismail, Irmi Zarina Md Noor, Sabariah Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians |
| title | Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians |
| title_full | Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians |
| title_fullStr | Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians |
| title_full_unstemmed | Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians |
| title_short | Effects of EPA/DHA from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight Malaysians |
| title_sort | effects of epa/dha from yellow-stripe scad and salmon on platelet-related cytokines of healthy overweight malaysians |
| url | http://psasir.upm.edu.my/id/eprint/79589/ http://psasir.upm.edu.my/id/eprint/79589/ http://psasir.upm.edu.my/id/eprint/79589/ http://psasir.upm.edu.my/id/eprint/79589/1/Effects%20of%20EPA%2BDHA%20.pdf |