Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats
Introduction: We investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety and memory impairment in scopolamine-induced dementia in Sprague-Dawley rats. Methods: Open field tests, elevated plus maze and Morris water maze were performed to assess general locomotor activity...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley Open Access
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/79562/ http://psasir.upm.edu.my/id/eprint/79562/1/Effect%20of%20zerumbone%20on%20scopolamine-induced%20memory%20impairment%20and%20anxiety-like%20behaviours%20in%20rats.pdf |
| _version_ | 1848858708905295872 |
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| author | Nasserizad, Sahba Jafarian Ling, King Hwa Hassan, Zurina Lua, Perimal Lewis Sulaiman, Mohd Roslan Perimal, Enoch Kumar |
| author_facet | Nasserizad, Sahba Jafarian Ling, King Hwa Hassan, Zurina Lua, Perimal Lewis Sulaiman, Mohd Roslan Perimal, Enoch Kumar |
| author_sort | Nasserizad, Sahba Jafarian |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: We investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety and memory impairment in scopolamine-induced dementia in Sprague-Dawley rats. Methods: Open field tests, elevated plus maze and Morris water maze were performed to assess general locomotor activity, anxiety-like behaviours and learning and memory processes respectively in rats pre treated with scopolamine. Results: Scopolamine-treated rats showed high total activity, stereotype, and total distance travelled in the open field arena, reduced number of entries to open arms, decreased the percentage of time spent in open arms and higher escape latency time in the Morris water maze test. Interestingly, single administration of zerumbone (1 and 10 mg/kg) reversed the hyperactivity, anxiety-like behaviours, and learning impairment effects of scopolamine in the three experimental model studied respectively. Discussion: Our findings demonstrated that the scopolamine-induced impairment of learning and memory was reversed by the administration of zerumbone. As a conclusion, our findings presented the positive effects of zerumbone on dementia-like behaviours in the animal model used and could possibly contribute for future research to manage hyperactivity, anxiety, and learning disabilities. |
| first_indexed | 2025-11-15T12:17:45Z |
| format | Article |
| id | upm-79562 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:17:45Z |
| publishDate | 2019 |
| publisher | Wiley Open Access |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-795622021-06-29T07:43:34Z http://psasir.upm.edu.my/id/eprint/79562/ Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats Nasserizad, Sahba Jafarian Ling, King Hwa Hassan, Zurina Lua, Perimal Lewis Sulaiman, Mohd Roslan Perimal, Enoch Kumar Introduction: We investigated the effects of zerumbone (1 and 10 mg/kg) against hyperactivity, anxiety and memory impairment in scopolamine-induced dementia in Sprague-Dawley rats. Methods: Open field tests, elevated plus maze and Morris water maze were performed to assess general locomotor activity, anxiety-like behaviours and learning and memory processes respectively in rats pre treated with scopolamine. Results: Scopolamine-treated rats showed high total activity, stereotype, and total distance travelled in the open field arena, reduced number of entries to open arms, decreased the percentage of time spent in open arms and higher escape latency time in the Morris water maze test. Interestingly, single administration of zerumbone (1 and 10 mg/kg) reversed the hyperactivity, anxiety-like behaviours, and learning impairment effects of scopolamine in the three experimental model studied respectively. Discussion: Our findings demonstrated that the scopolamine-induced impairment of learning and memory was reversed by the administration of zerumbone. As a conclusion, our findings presented the positive effects of zerumbone on dementia-like behaviours in the animal model used and could possibly contribute for future research to manage hyperactivity, anxiety, and learning disabilities. Wiley Open Access 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/79562/1/Effect%20of%20zerumbone%20on%20scopolamine-induced%20memory%20impairment%20and%20anxiety-like%20behaviours%20in%20rats.pdf Nasserizad, Sahba Jafarian and Ling, King Hwa and Hassan, Zurina and Lua, Perimal Lewis and Sulaiman, Mohd Roslan and Perimal, Enoch Kumar (2019) Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5. pp. 637-643. ISSN 2352-8737 https://www.sciencedirect.com/science/article/pii/S2352873719300708 10.1016/j.trci.2019.09.009 |
| spellingShingle | Nasserizad, Sahba Jafarian Ling, King Hwa Hassan, Zurina Lua, Perimal Lewis Sulaiman, Mohd Roslan Perimal, Enoch Kumar Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| title | Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| title_full | Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| title_fullStr | Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| title_full_unstemmed | Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| title_short | Effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| title_sort | effect of zerumbone on scopolamine-induced memory impairment and anxiety-like behaviours in rats |
| url | http://psasir.upm.edu.my/id/eprint/79562/ http://psasir.upm.edu.my/id/eprint/79562/ http://psasir.upm.edu.my/id/eprint/79562/ http://psasir.upm.edu.my/id/eprint/79562/1/Effect%20of%20zerumbone%20on%20scopolamine-induced%20memory%20impairment%20and%20anxiety-like%20behaviours%20in%20rats.pdf |