Recent advances and challenges in microneedle-mediated transdermal protein and peptide drug delivery
The identification of wheat and barley genes controlling important agronomic traits using positional cloning has traditionally been a challenging and time-consuming procedure. This is due to the enormous genome size and high repeat content from transposable elements (TEs). Low marker density, suppre...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Book Section |
| Language: | English |
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Academic Press
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/78928/ http://psasir.upm.edu.my/id/eprint/78928/1/Recent%20advances%20and%20challenges%20in%20microneedle-mediated%20transdermal%20protein%20and%20peptide%20drug%20delivery.pdf |
| _version_ | 1848858568344731648 |
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| author | Chandran, Rubhan Mohd. Tohit, Eusni Rahayu Stanslas, Johnson Tuan Mahmood, Tuan Mazlelaa |
| author2 | Tekade, Rakesh K. |
| author_facet | Tekade, Rakesh K. Chandran, Rubhan Mohd. Tohit, Eusni Rahayu Stanslas, Johnson Tuan Mahmood, Tuan Mazlelaa |
| author_sort | Chandran, Rubhan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The identification of wheat and barley genes controlling important agronomic traits using positional cloning has traditionally been a challenging and time-consuming procedure. This is due to the enormous genome size and high repeat content from transposable elements (TEs). Low marker density, suppressed recombination, and the high cost of generating a physical contig across a genetically defined Recent developments in biotechnological techniques such as protein purification and recombinant DNA technology have led to the production of many commercial protein- and peptide-based drugs. Although the intravenous route is the preferred mode of protein drug delivery, it is associated with pain, cost, and sterility concerns. These complications can be avoided with minimally invasive microneedle (MN)-mediated transdermal drug delivery to provide better patient compliance. Currently, various formulation and microfabrication techniques are being developed to facilitate MN-mediated protein drug delivery. The design of MNs primarily relies on the heterogeneous and viscoelastic property of the skin. Presently, several MN brands have been successfully marketed and others are actively undergoing clinical trials to confirm their efficacy in the delivery of drug candidates. This chapter mainly highlights the latest developments and limitations in MN-mediated protein and peptide drug delivery. The proposed mechanism of entry of drugs administered via MN into blood circulation also has been discussed. |
| first_indexed | 2025-11-15T12:15:31Z |
| format | Book Section |
| id | upm-78928 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:15:31Z |
| publishDate | 2019 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-789282021-07-21T21:11:50Z http://psasir.upm.edu.my/id/eprint/78928/ Recent advances and challenges in microneedle-mediated transdermal protein and peptide drug delivery Chandran, Rubhan Mohd. Tohit, Eusni Rahayu Stanslas, Johnson Tuan Mahmood, Tuan Mazlelaa The identification of wheat and barley genes controlling important agronomic traits using positional cloning has traditionally been a challenging and time-consuming procedure. This is due to the enormous genome size and high repeat content from transposable elements (TEs). Low marker density, suppressed recombination, and the high cost of generating a physical contig across a genetically defined Recent developments in biotechnological techniques such as protein purification and recombinant DNA technology have led to the production of many commercial protein- and peptide-based drugs. Although the intravenous route is the preferred mode of protein drug delivery, it is associated with pain, cost, and sterility concerns. These complications can be avoided with minimally invasive microneedle (MN)-mediated transdermal drug delivery to provide better patient compliance. Currently, various formulation and microfabrication techniques are being developed to facilitate MN-mediated protein drug delivery. The design of MNs primarily relies on the heterogeneous and viscoelastic property of the skin. Presently, several MN brands have been successfully marketed and others are actively undergoing clinical trials to confirm their efficacy in the delivery of drug candidates. This chapter mainly highlights the latest developments and limitations in MN-mediated protein and peptide drug delivery. The proposed mechanism of entry of drugs administered via MN into blood circulation also has been discussed. Academic Press Tekade, Rakesh K. 2019 Book Section PeerReviewed text en http://psasir.upm.edu.my/id/eprint/78928/1/Recent%20advances%20and%20challenges%20in%20microneedle-mediated%20transdermal%20protein%20and%20peptide%20drug%20delivery.pdf Chandran, Rubhan and Mohd. Tohit, Eusni Rahayu and Stanslas, Johnson and Tuan Mahmood, Tuan Mazlelaa (2019) Recent advances and challenges in microneedle-mediated transdermal protein and peptide drug delivery. In: Biomaterials and Bionanotechnology. Advances in Pharmaceutical Product Development and Research . Academic Press, United Kingdom, 496 - 525. ISBN 9780128144275; EISBN: 9780128144282 https://www.sciencedirect.com/science/article/pii/B9780128144275000147#! 10.1016/B978-0-12-814427-5.00014-7 |
| spellingShingle | Chandran, Rubhan Mohd. Tohit, Eusni Rahayu Stanslas, Johnson Tuan Mahmood, Tuan Mazlelaa Recent advances and challenges in microneedle-mediated transdermal protein and peptide drug delivery |
| title | Recent advances and challenges in microneedle-mediated transdermal
protein and peptide drug delivery |
| title_full | Recent advances and challenges in microneedle-mediated transdermal
protein and peptide drug delivery |
| title_fullStr | Recent advances and challenges in microneedle-mediated transdermal
protein and peptide drug delivery |
| title_full_unstemmed | Recent advances and challenges in microneedle-mediated transdermal
protein and peptide drug delivery |
| title_short | Recent advances and challenges in microneedle-mediated transdermal
protein and peptide drug delivery |
| title_sort | recent advances and challenges in microneedle-mediated transdermal
protein and peptide drug delivery |
| url | http://psasir.upm.edu.my/id/eprint/78928/ http://psasir.upm.edu.my/id/eprint/78928/ http://psasir.upm.edu.my/id/eprint/78928/ http://psasir.upm.edu.my/id/eprint/78928/1/Recent%20advances%20and%20challenges%20in%20microneedle-mediated%20transdermal%20protein%20and%20peptide%20drug%20delivery.pdf |