Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri
Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77981/ http://psasir.upm.edu.my/id/eprint/77981/1/77981.pdf |
| _version_ | 1848858379944984576 |
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| author | Mah, Siau Hui Ee, Gwendoline Cheng Lian Teh, Soek Sin Rahmani, Mawardi Lim, Yang Mooi Go, Rusea |
| author_facet | Mah, Siau Hui Ee, Gwendoline Cheng Lian Teh, Soek Sin Rahmani, Mawardi Lim, Yang Mooi Go, Rusea |
| author_sort | Mah, Siau Hui |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 1–7 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells. |
| first_indexed | 2025-11-15T12:12:31Z |
| format | Article |
| id | upm-77981 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:12:31Z |
| publishDate | 2012 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-779812020-06-01T03:11:10Z http://psasir.upm.edu.my/id/eprint/77981/ Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri Mah, Siau Hui Ee, Gwendoline Cheng Lian Teh, Soek Sin Rahmani, Mawardi Lim, Yang Mooi Go, Rusea Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 1–7 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells. MDPI 2012 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77981/1/77981.pdf Mah, Siau Hui and Ee, Gwendoline Cheng Lian and Teh, Soek Sin and Rahmani, Mawardi and Lim, Yang Mooi and Go, Rusea (2012) Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri. Molecules, 17 (7). pp. 8303-8311. ISSN 1420-3049 https://www.mdpi.com/1420-3049/17/7/8303 10.3390/molecules17078303 |
| spellingShingle | Mah, Siau Hui Ee, Gwendoline Cheng Lian Teh, Soek Sin Rahmani, Mawardi Lim, Yang Mooi Go, Rusea Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri |
| title | Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri |
| title_full | Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri |
| title_fullStr | Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri |
| title_full_unstemmed | Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri |
| title_short | Phylattrin, a new cytotoxic xanthone from Calophyllum soulattri |
| title_sort | phylattrin, a new cytotoxic xanthone from calophyllum soulattri |
| url | http://psasir.upm.edu.my/id/eprint/77981/ http://psasir.upm.edu.my/id/eprint/77981/ http://psasir.upm.edu.my/id/eprint/77981/ http://psasir.upm.edu.my/id/eprint/77981/1/77981.pdf |