Triterpene composition and bioactivities of Centella asiatica
Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC-PAD on an Excil ODS 5 mm (C18) column for the simulta...
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| Format: | Article |
| Language: | English |
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MDPI
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77954/ http://psasir.upm.edu.my/id/eprint/77954/1/77954.pdf |
| _version_ | 1848858372309254144 |
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| author | Hashim, Puziah Sidek, Hamidah Mohd Helan, Mohd Helme Sabery, Aidawati M. Palanisamy, Uma Devi Adenan, Mohd Ilham |
| author_facet | Hashim, Puziah Sidek, Hamidah Mohd Helan, Mohd Helme Sabery, Aidawati M. Palanisamy, Uma Devi Adenan, Mohd Ilham |
| author_sort | Hashim, Puziah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC-PAD on an Excil ODS 5 mm (C18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. Centella was found to contain significant amounts of madecassoside (3.10 ± 4.58 mg/mL) and asiaticoside (1.97 ± 2.65 mg/mL), but was low in asiatic and madecassic acid. The highest collagen synthesis was found at 50 mg/mL of Centella extracts. The antioxidant activity of Centella (84%) was compared to grape seed extract (83%) and Vitamin C (88%). Its lipolytic activity was observed by the release of glycerol (115.9 µmol/L) at 0.02% concentration. Centella extracts exhibited similar UV protection effect to OMC at 10% concentration. In view of these results, the potential application of Centella in food and pharmaceutical industries is now widely open. |
| first_indexed | 2025-11-15T12:12:24Z |
| format | Article |
| id | upm-77954 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:12:24Z |
| publishDate | 2011 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-779542020-05-04T17:51:39Z http://psasir.upm.edu.my/id/eprint/77954/ Triterpene composition and bioactivities of Centella asiatica Hashim, Puziah Sidek, Hamidah Mohd Helan, Mohd Helme Sabery, Aidawati M. Palanisamy, Uma Devi Adenan, Mohd Ilham Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC-PAD on an Excil ODS 5 mm (C18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. Centella was found to contain significant amounts of madecassoside (3.10 ± 4.58 mg/mL) and asiaticoside (1.97 ± 2.65 mg/mL), but was low in asiatic and madecassic acid. The highest collagen synthesis was found at 50 mg/mL of Centella extracts. The antioxidant activity of Centella (84%) was compared to grape seed extract (83%) and Vitamin C (88%). Its lipolytic activity was observed by the release of glycerol (115.9 µmol/L) at 0.02% concentration. Centella extracts exhibited similar UV protection effect to OMC at 10% concentration. In view of these results, the potential application of Centella in food and pharmaceutical industries is now widely open. MDPI 2011 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77954/1/77954.pdf Hashim, Puziah and Sidek, Hamidah and Mohd Helan, Mohd Helme and Sabery, Aidawati and M. Palanisamy, Uma Devi and Adenan, Mohd Ilham (2011) Triterpene composition and bioactivities of Centella asiatica. Molecules, 16 (2). pp. 1310-1322. ISSN 1420-3049 https://www.mdpi.com/1420-3049/16/2/1310 10.3390/molecules16021310 |
| spellingShingle | Hashim, Puziah Sidek, Hamidah Mohd Helan, Mohd Helme Sabery, Aidawati M. Palanisamy, Uma Devi Adenan, Mohd Ilham Triterpene composition and bioactivities of Centella asiatica |
| title | Triterpene composition and bioactivities of Centella asiatica |
| title_full | Triterpene composition and bioactivities of Centella asiatica |
| title_fullStr | Triterpene composition and bioactivities of Centella asiatica |
| title_full_unstemmed | Triterpene composition and bioactivities of Centella asiatica |
| title_short | Triterpene composition and bioactivities of Centella asiatica |
| title_sort | triterpene composition and bioactivities of centella asiatica |
| url | http://psasir.upm.edu.my/id/eprint/77954/ http://psasir.upm.edu.my/id/eprint/77954/ http://psasir.upm.edu.my/id/eprint/77954/ http://psasir.upm.edu.my/id/eprint/77954/1/77954.pdf |